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Protein Ontology report - TGF-beta 1 sequence variant T81H (human)
PR:000000399 -
http://purl.obolibrary.org/obo/PR_000000399
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:000000399
PRO name
TGF-beta 1 sequence variant T81H (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFB1/var:T81H
PRO-proteoform-std
:
EXACT:
UniProtKB:P01137
, Tyr-81,
CHEBI:29979
Other
:
EXACT:
TGF-beta 1 sequence variant 2 (human)
Definition
"A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Tyr-81 of the amino acid sequence represented by
UniProtKB:P01137
.
UniProtKB:P01137
, Tyr-81,
CHEBI:29979
." [
PMID:11062463
,
PMID:12493741
, PRO:CNA, PRO:DAN]
PRO Category
organism-sequence
Parent
PR:P01137
transforming growth factor beta-1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB_VAR:VAR_017607
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-sequence
PR:000000399
TGF-beta 1 sequence variant T81H (human)
hTGFB1/var:T81H
"A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Tyr-81 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Tyr-81, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000021903
TGF-beta 1 sequence variant T81H, signal peptide removed form (human)
hTGFB1/var:T81H/SigPep-
"A TGF-beta 1 sequence variant T81H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Tyr-81, CHEBI:29979." [PRO:DAN]
organism-modification
PR:000000619
TGF-beta 1 sequence variant T81H cleaved 1 (human)
hTGFB1/var:T81H/Clv:1
"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000000620
TGF-beta 1 sequence variant T81H cleaved 2 (human)
hTGFB1/var:T81H/Clv:2
"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000399
hTGFB1/var:T81H
UniProtKB:P01137, Tyr-81, CHEBI:29979
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11062463
associated_with_disease_progression
DO:4997
Camurati-Engelmann disease
PMID:12493741
located_in
SO:0001558
polypeptide_localization_variant
PMID:11062463
;
PMID:12493741
PR:000000619
hTGFB1/var:T81H/Clv:1
UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979
located_in
SO:0001558
polypeptide_localization_variant
PMID:12493741
PR:000000620
hTGFB1/var:T81H/Clv:2
UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979
located_in
GO:0005615
extracellular space
PMID:12493741
