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Protein Ontology report - smad1 isoform 1 phosphorylated form
PR:000000571 - http://purl.obolibrary.org/obo/PR_000000571
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000571   
  PRO namesmad1 isoform 1 phosphorylated form 
  Synonyms
PRO-Short-label: EXACT:SMAD1/iso:1/PhosRes+
  Definition"A smad1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] 
  PRO Categorymodification 
  ParentPR:000000467 smad1 isoform 1
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification4                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
modification


PR:000000571
smad1 isoform 1 phosphorylated form
SMAD1/iso:1/PhosRes+
"A smad1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000570
smad1 isoform 1 phosphorylated and ubiquitinated form
SMAD1/iso:1/PhosUbiq+
"A smad1 isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000000648
smad1 isoform 1 phosphorylated and ubiquitinated 1
SMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated form that has been phosphorylated at the two last C-terminal SSxS motif and has been ubiquitinated by E3 ubiquitin-protein ligase SMURF1 (PR:000000466). Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]

organism-modification


PR:000036553
smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000647
smad1 isoform 1 phosphorylated 1
SMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PMID:9136927]
Yes
organism-modification


PR:000026334
smad1 isoform 1 phosphorylated 1 (human)
hSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]
Yes
organism-modification


PR:000026724
smad1 isoform 1 phosphorylated 1 (mouse)
mSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007165 signal transductionPR:000026334 hSMAD1/iso:1/Phos:1 PMID:9759503
GO:0008285 negative regulation of cell population proliferationPR:000026724 mSMAD1/iso:1/Phos:1 PMID:15899870
GO:0030509 BMP signaling pathwayPR:000026334 hSMAD1/iso:1/Phos:1 PMID:8653785
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:12370310; PMID:15198985
GO:0030514 negative regulation of BMP signaling pathwayPR:000036553 hSMAD1/iso:1/PhosUbiq:1 PMID:12857866

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000000647 SMAD1/iso:1/Phos:1 PMID:10708949
GO:0005515 protein bindingPR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
GO:0046332 SMAD bindingPR:000026334 hSMAD1/iso:1/Phos:1 PMID:9136927

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000026334 hSMAD1/iso:1/Phos:1 PMID:11509558; PMID:9759503
PR:000026724 mSMAD1/iso:1/Phos:1 PMID:10504300; PMID:12151307; PMID:12370310
GO:0005667 transcription factor complexPR:000026724 mSMAD1/iso:1/Phos:1 PMID:14633973
GO:0005769 early endosomePR:000026724 mSMAD1/iso:1/Phos:1 PMID:17592637