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Protein Ontology report - smad3 isoform 1 phosphorylated form
PR:000000578 - http://purl.obolibrary.org/obo/PR_000000578
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000578   
  PRO namesmad3 isoform 1 phosphorylated form 
  Synonyms
PRO-Short-label: EXACT:SMAD3/iso:1/PhosRes+
  Definition"A smad3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] 
  PRO Categorymodification 
  ParentPR:000000475 smad3 isoform 1
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification6                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
modification


PR:000000578
smad3 isoform 1 phosphorylated form
SMAD3/iso:1/PhosRes+
"A smad3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000577
smad3 isoform 1 acetylated and phosphorylated form
SMAD3/iso:1/AcPhos+
"A smad3 isoform 1 that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000657
smad3 isoform 1 acetylated and phosphorylated 1
SMAD3/iso:1/AcPhos:1
"A smad3 isoform 1 acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated at a Lys residue within the MH1 domain by coactivators, such as CBP and EP300. Example: UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756]

organism-modification


PR:000036557
smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]
Yes
modification


PR:000000658
smad3 isoform 1 phosphorylated 1
SMAD3/iso:1/Phos:1
"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the transforming growth factor beta signaling pathway. Example: UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PMID:8774881]

organism-modification


PR:000026333
smad3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]
Yes
organism-modification


PR:000036558
smad3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]
Yes
modification


PR:000000659
smad3 isoform 1 phosphorylated 2
SMAD3/iso:1/Phos:2
"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and the clusters of [ST]P motifs within the MH1-MH2 domain linker region by G1 cyclin-dependent kinases (CDK4 and CDK2) leading to CDK inhibition of its transcriptional activity and antiproliferative function. Example: UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]

organism-modification


PR:000036560
smad3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000660
smad3 isoform 1 phosphorylated 3
SMAD3/iso:1/Phos:3
"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region through the MAP kinase cascade in oncogenic Ras-activated pathway. Example: UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]

organism-modification


PR:000036561
smad3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026333 hSMAD3/iso:1/Phos:1
UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046		 acts_upstream_of_or_withinGO:0006366 transcription by RNA polymerase II PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881; PMID:9380693
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15084259
GO:0046332 SMAD binding PMID:15350224; PMID:9311995
located_inGO:0005634 nucleus PMID:10846168; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
PR:000036557 hSMAD3/iso:1/AcPhos:1
UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003700 DNA-binding transcription factor activity PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1
UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046		 enablesGO:0003690 double-stranded DNA binding PMID:15282343
GO:0003700 DNA-binding transcription factor activity PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15464984; PMID:9702197
located_inGO:0005634 nucleus PMID:12943993; PMID:15282343
GO:0005667 transcription factor complex PMID:9702197
PR:000036560 mSMAD3/iso:1/Phos:2
UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046		 enablesdecreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418
PR:000036561 mSMAD3/iso:1/Phos:3
UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981