Protein Ontology

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Protein Ontology report - smad3 isoform 1 phosphorylated form

PR:000000578 - http://purl.obolibrary.org/obo/PR_000000578

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Ontology Information

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PRO ID

PR:000000578

PRO name

smad3 isoform 1 phosphorylated form

Synonyms

PRO-Short-label:

EXACT:

SMAD3/iso:1/PhosRes+

Definition

"A smad3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

PRO Category

modification

Parent

PR:000000475 smad3 isoform 1
PR:000037070 phosphoprotein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	6	Organism-Modification	5

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

modification

PR:000000578 smad3 isoform 1 phosphorylated form

SMAD3/iso:1/PhosRes+

modification

PR:000000577 smad3 isoform 1 acetylated and phosphorylated form

SMAD3/iso:1/AcPhos+

modification

PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1

SMAD3/iso:1/AcPhos:1

organism-modification

PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)

hSMAD3/iso:1/AcPhos:1

modification

PR:000000658 smad3 isoform 1 phosphorylated 1

SMAD3/iso:1/Phos:1

organism-modification

PR:000026333 smad3 isoform 1 phosphorylated 1 (human)

hSMAD3/iso:1/Phos:1

organism-modification

PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse)

mSMAD3/iso:1/Phos:1

modification

PR:000000659 smad3 isoform 1 phosphorylated 2

SMAD3/iso:1/Phos:2

organism-modification

PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse)

mSMAD3/iso:1/Phos:2

modification

PR:000000660 smad3 isoform 1 phosphorylated 3

SMAD3/iso:1/Phos:3

organism-modification

PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse)

mSMAD3/iso:1/Phos:3

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000026333 hSMAD3/iso:1/Phos:1 UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046	acts_upstream_of_or_within	GO:0006366 transcription by RNA polymerase II	PMID:10823886
	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:8774881; PMID:9380693
	enables	GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:10823886; PMID:12943993
		GO:0008134 transcription factor binding	PMID:15084259
		GO:0046332 SMAD binding	PMID:15350224; PMID:9311995
	located_in	GO:0005634 nucleus	PMID:10846168; PMID:15280432
	located_in	GO:0005667 transcription factor complex	PMID:12374795
PR:000036557 hSMAD3/iso:1/AcPhos:1 UniProtKB:P84022-1, Lys-19, MOD:00064\|Ser-423/Ser-425, MOD:00046	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:17074756
	enables	GO:0003700 DNA-binding transcription factor activity	PMID:17074756
	located_in	GO:0005634 nucleus	PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1 UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046	enables	GO:0003690 double-stranded DNA binding	PMID:15282343
		GO:0003700 DNA-binding transcription factor activity	PMID:10823886; PMID:12943993
		GO:0008134 transcription factor binding	PMID:15464984; PMID:9702197
	located_in	GO:0005634 nucleus	PMID:12943993; PMID:15282343
	located_in	GO:0005667 transcription factor complex	PMID:9702197
PR:000036560 mSMAD3/iso:1/Phos:2 UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047\|Ser-213, MOD:00046	enables	decreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036558 mSMAD3/iso:1/Phos:1	PMID:15241418
PR:000036561 mSMAD3/iso:1/Phos:3 UniProtKB:Q8BUN5-1, Thr-179, MOD:00047\|Ser-204/Ser-208/Ser-213, MOD:00046	enables	NOT GO:0003713 transcription coactivator activity	PMID:10197981
	located_in	GO:0005737 cytoplasm	PMID:10197981