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Protein Ontology report - TGF-beta 1 isoform 1 inactive form
PR:000000618 - http://purl.obolibrary.org/obo/PR_000000618
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000618   
  PRO nameTGF-beta 1 isoform 1 inactive form 
  Synonyms
PRO-Short-label: EXACT:TGFB1/iso:1/inactive
Other: RELATED:TGF beta latent complex | TGFb latent complex
  Definition"A TGF-beta 1 isoform 1, signal peptide removed form that has been cleaved at the dibasic cleavage site, rendering the latency associated peptide (LAP) and the mature protein non-covalently bound. This form is glycosylated mainly at either one or the two first consensus glycosylation sites within the LAP sequence. Example: UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:3162913, PMID:3185545, PRO:CNA, PRO:DAN] 
  PRO Categorymodification 
  ParentPR:000025454 TGF-beta 1 isoform 1, signal peptide removed form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
modification


PR:000000618 TGF-beta 1 isoform 1 inactive form
TGFB1/iso:1/inactive

organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026335 hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:2677679; PMID:3162913
GO:0042803 protein homodimerization activity PMID:3162913
located_inGO:0031012 extracellular matrix PMID:17015622; PMID:8294500
GO:0032991 protein-containing complex PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive
UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:1448117; PMID:2677679
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:1448117
located_inGO:0032991 protein-containing complex PMID:1448117; PMID:2677679
PR:000036529 mTGFB1/iso:1/inactive
UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
located_inGO:0031012 extracellular matrix PMID:9008713