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Protein Ontology report - TGF-beta 1 sequence variant H222D cleaved 1 (human)
PR:000000623 - http://purl.obolibrary.org/obo/PR_000000623
 
    Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:000000623   
  PRO nameTGF-beta 1 sequence variant H222D cleaved 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFB1/var:H222D/Clv:1
PRO-proteoform-std: EXACT:UniProtKB:P01137, 279-390, His-222, CHEBI:29958
Other: EXACT:TGF-beta 1 sequence variant 5 cleaved 1 (human)
  Definition"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN] 
  PRO Categoryorganism-modification 
  ParentPR:000018292 TGF-beta 1 proteolytic cleavage product
PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Term Hierarchy
  Visualization
DAG: OLS:
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000623 hTGFB1/var:H222D/Clv:1
UniProtKB:P01137, 279-390, His-222, CHEBI:29958
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
GO:0043066 negative regulation of apoptotic process PMID:12493741
enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741
located_inGO:0005615 extracellular space PMID:12493741