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Protein Ontology report - TGF-beta 1 sequence variant H222D cleaved 1 (human) PR:000000623 - http://purl.obolibrary.org/obo/PR_000000623        Annotations       Ontology Information Show OBO stanza / PAF / GPI   PRO ID PR:000000623      PRO name TGF-beta 1 sequence variant H222D cleaved 1 (human)    Synonyms PRO-Short-label: EXACT: hTGFB1/var:H222D/Clv:1 PRO-proteoform-std: EXACT: UniProtKB:P01137, 279-390, His-222, CHEBI:29958 Other: EXACT: TGF-beta 1 sequence variant 5 cleaved 1 (human)   Definition "A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]    PRO Category organism-modification    Parent PR:000018292 TGF-beta 1 proteolytic cleavage product PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)   Taxon NCBITaxon:9606 Homo sapiens   Term Hierarchy   Visualization DAG: OLS: Back to top Functional Annotation (PRO-centric view) Switch to GO Centric View    PRO Term GO Annotation Evidence PR:000000623 hTGFB1/var:H222D/Clv:1 UniProtKB:P01137, 279-390, His-222, CHEBI:29958 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741 GO:0043066 negative regulation of apoptotic process PMID:12493741 enables increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741 located_in GO:0005615 extracellular space PMID:12493741