back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - TGF-beta 1 sequence variant R218H cleaved 2 (human)
PR:000000628 - http://purl.obolibrary.org/obo/PR_000000628
 
    Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:000000628   
  PRO nameTGF-beta 1 sequence variant R218H cleaved 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFB1/var:R218H/Clv:2
PRO-proteoform-std: EXACT:UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979
Other: EXACT:TGF-beta 1 sequence variant 4 cleaved 2 (human)
  Definition"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN] 
  PRO Categoryorganism-modification 
  ParentPR:000018292 TGF-beta 1 proteolytic cleavage product
PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Cellular Location GO Term

Protein Forms & Complexes

Evidence
SO:0001561 polypeptide_partial_loss_of_functionPR:000000628 hTGFB1/var:R218H/Clv:2 PMID:11278244
SO:0001601 conformational_change_variantPR:000000628 hTGFB1/var:R218H/Clv:2 PMID:11278244