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Protein Ontology report - smad2 isoform Long phosphorylated 1
PR:000000650 - http://purl.obolibrary.org/obo/PR_000000650
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000650   
  PRO namesmad2 isoform Long phosphorylated 1 
  Synonyms
PRO-Short-label: EXACT:SMAD2/iso:Long/Phos:1
Other: RELATED:TGF-beta receptor-activated smad2
  Definition"A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966] 
  PRO Categorymodification 
  ParentPR:000000574 smad2 isoform Long phosphorylated form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
modification


PR:000000650 smad2 isoform Long phosphorylated 1
SMAD2/iso:Long/Phos:1

Yes
organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
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SMAD2/iso:Long/Phos:1 forms found in complexes   

SMAD2/iso:Long/Phos:1 Component
 Complexes
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025971 smad2-smad4-ski protein complex 1
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025942 mSMAD2/iso:Long/Phos:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006355 regulation of DNA-templated transcriptionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:15690394; PMID:9689110
GO:0007165 signal transductionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8752209; PMID:8980228; PMID:9346966
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:11262418
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8752209; PMID:8980228
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:11262418
GO:0060395 SMAD protein signal transductionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9346966

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8980228; PMID:9346966
GO:0003713 transcription coactivator activityPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9689110
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:15282343
GO:0046332 SMAD bindingPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9311995
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:11043574

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9006934; PMID:9346966
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:11557747