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Protein Ontology report - calcium-activated calmodulin-binding potassium channel alpha subunit
PR:000000668 - http://purl.obolibrary.org/obo/PR_000000668
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000000668   
  PRO namecalcium-activated calmodulin-binding potassium channel alpha subunit 
  Definition"A calcium-activated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. They are subunits of the small conductance calcium-activated channels. SK channels are independent of voltage and gated solely by intracellular calcium. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the calcium-binding protein calmodulin. Calmodulin binds to the SK channel through the Calmodulin binding domain (Pfam:PF02888), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when calcium binds the EF hands in the N-lobe of calmodulin. These channels play a crucial role in hyperpolarizing the membrane potential of excitable and nonexcitable cells." [PMID:10026195, PMID:11323678] 
  PRO Categoryfamily 
  ParentPR:000044649 calcium-activated potassium channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family0                                                  Organism-Family 0                                        
         Gene0                                                  Organism-Gene 0                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038511
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit
SMAD9/iso:3/Phos:1

gene


PR:000000700 intermediate conductance calcium-activated potassium channel protein 4
KCNN4

organism-gene


PR:O15554 intermediate conductance calcium-activated potassium channel protein 4 (human)
hKCNN4
Yes
organism-sequence


PR:O15554-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
hKCNN4/iso:1
Yes
organism-modification


PR:000071778 intermediate conductance calcium-activated potassium channel protein 4 deaminated 1 (human)
hKCNN4/Deam:1

organism-gene


PR:O89109 intermediate conductance calcium-activated potassium channel protein 4 (mouse)
mKCNN4

organism-sequence


PR:O89109-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
mKCNN4/iso:1
Yes
organism-gene


PR:Q9QYW1 intermediate conductance calcium-activated potassium channel protein 4 (rat)
rKCNN4

sequence


PR:000000753 intermediate conductance calcium-activated potassium channel protein 4 isoform 1
KCNN4/iso:1

organism-sequence


PR:O15554-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
hKCNN4/iso:1
Yes
organism-sequence


PR:O89109-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
mKCNN4/iso:1
Yes
gene


PR:000000712 small conductance calcium-activated potassium channel protein 1
KCNN1





PR:000000761 small conductance calcium-activated potassium channel protein 1 isoform 1





PR:000002605 small conductance calcium-activated potassium channel protein 1 isoform 1 unmodified form

organism-sequence


PR:Q9EQR3-1 small conductance calcium-activated potassium channel protein 1 isoform 1 (mouse)
mKCNN1/iso:1
Yes




PR:000000762 small conductance calcium-activated potassium channel protein 1 isoform 2

organism-sequence


PR:Q92952-2 small conductance calcium-activated potassium channel protein 1 isoform 2 (human)
hKCNN1/iso:2
Yes




PR:000000763 small conductance calcium-activated potassium channel protein 1 isoform I

organism-sequence


PR:Q9EQR3-2 small conductance calcium-activated potassium channel protein 1 isoform 2 (mouse)
mKCNN1/iso:2





PR:000000764 small conductance calcium-activated potassium channel protein 1 isoform II

organism-sequence


PR:Q9EQR3-9 small conductance calcium-activated potassium channel protein 1 isoform II (mouse)
mKCNN1/iso:II
Yes




PR:000000765 small conductance calcium-activated potassium channel protein 1 isoform III

organism-sequence


PR:Q9EQR3-8 small conductance calcium-activated potassium channel protein 1 isoform III (mouse)
mKCNN1/iso:III
Yes




PR:000000766 small conductance calcium-activated potassium channel protein 1 isoform IV

organism-sequence


PR:Q9EQR3-7 small conductance calcium-activated potassium channel protein 1 isoform IV (mouse)
mKCNN1/iso:IV
Yes




PR:000000767 small conductance calcium-activated potassium channel protein 1 isoform V

organism-sequence


PR:Q9EQR3-3 small conductance calcium-activated potassium channel protein 1 isoform V (mouse)
mKCNN1/iso:V
Yes




PR:000000768 small conductance calcium-activated potassium channel protein 1 isoform VI

organism-sequence


PR:Q9EQR3-4 small conductance calcium-activated potassium channel protein 1 isoform VI (mouse)
mKCNN1/iso:VI
Yes




PR:000000769 small conductance calcium-activated potassium channel protein 1 isoform VII

organism-sequence


PR:Q9EQR3-5 small conductance calcium-activated potassium channel protein 1 isoform VII (mouse)
mKCNN1/iso:VII
Yes




PR:000000770 small conductance calcium-activated potassium channel protein 1 isoform VIII

organism-sequence


PR:Q9EQR3-6 small conductance calcium-activated potassium channel protein 1 isoform VIII (mouse)
mKCNN1/iso:VIII
Yes
organism-gene


PR:P70606 small conductance calcium-activated potassium channel protein 1 (rat)
rKCNN1

organism-gene


PR:Q92952 small conductance calcium-activated potassium channel protein 1 (human)
hKCNN1

organism-sequence


PR:Q92952-1 small conductance calcium-activated potassium channel protein 1 isoform h1 (human)
hKCNN1/iso:h1

organism-sequence


PR:Q92952-2 small conductance calcium-activated potassium channel protein 1 isoform 2 (human)
hKCNN1/iso:2
Yes
organism-modification


PR:000084864 small conductance calcium-activated potassium channel protein 1 phosphorylated 1 (human)
hKCNN1/Phos:1

organism-gene


PR:Q9EQR3 small conductance calcium-activated potassium channel protein 1 (mouse)
mKCNN1

organism-sequence


PR:Q9EQR3-1 small conductance calcium-activated potassium channel protein 1 isoform 1 (mouse)
mKCNN1/iso:1
Yes
organism-sequence


PR:Q9EQR3-2 small conductance calcium-activated potassium channel protein 1 isoform 2 (mouse)
mKCNN1/iso:2

organism-sequence


PR:Q9EQR3-3 small conductance calcium-activated potassium channel protein 1 isoform V (mouse)
mKCNN1/iso:V
Yes
organism-sequence


PR:Q9EQR3-4 small conductance calcium-activated potassium channel protein 1 isoform VI (mouse)
mKCNN1/iso:VI
Yes
organism-sequence


PR:Q9EQR3-5 small conductance calcium-activated potassium channel protein 1 isoform VII (mouse)
mKCNN1/iso:VII
Yes
organism-sequence


PR:Q9EQR3-6 small conductance calcium-activated potassium channel protein 1 isoform VIII (mouse)
mKCNN1/iso:VIII
Yes
organism-sequence


PR:Q9EQR3-7 small conductance calcium-activated potassium channel protein 1 isoform IV (mouse)
mKCNN1/iso:IV
Yes
organism-sequence


PR:Q9EQR3-8 small conductance calcium-activated potassium channel protein 1 isoform III (mouse)
mKCNN1/iso:III
Yes
organism-sequence


PR:Q9EQR3-9 small conductance calcium-activated potassium channel protein 1 isoform II (mouse)
mKCNN1/iso:II
Yes




PR:000000713 small conductance calcium-activated potassium channel protein 2





PR:000000771 small conductance calcium-activated potassium channel protein 2 isoform 1





PR:P58390-1 small conductance calcium-activated potassium channel protein 2 isoform 1 (mouse)





PR:Q9H2S1-1 small conductance calcium-activated potassium channel protein 2 isoform 1 (human)





PR:000000772 small conductance calcium-activated potassium channel protein 2 isoform 2





PR:Q9H2S1-2 small conductance calcium-activated potassium channel protein 2 isoform 2 (human)





PR:000035381 small conductance calcium-activated potassium channel protein 2 isoform 3





PR:B4YDY0 small conductance calcium-activated potassium channel protein 2 isoform 3 (mouse)





PR:P58390 small conductance calcium-activated potassium channel protein 2 (mouse)





PR:B4YDY0 small conductance calcium-activated potassium channel protein 2 isoform 3 (mouse)





PR:P58390-1 small conductance calcium-activated potassium channel protein 2 isoform 1 (mouse)





PR:P70604 small conductance calcium-activated potassium channel protein 2 (rat)





PR:Q7KVW5 small conductance calcium-activated potassium channel protein (fruit fly)





PR:Q7KVW5-1 small conductance calcium-activated potassium channel protein isoform K (fruit fly)





PR:Q7KVW5-2 small conductance calcium-activated potassium channel protein isoform J (fruit fly)





PR:Q7KVW5-4 small conductance calcium-activated potassium channel protein isoform L (fruit fly)





PR:Q7KVW5-5 small conductance calcium-activated potassium channel protein isoform M (fruit fly)





PR:Q7KVW5-6 small conductance calcium-activated potassium channel protein isoform N (fruit fly)





PR:Q7KVW5-7 small conductance calcium-activated potassium channel protein isoform I (fruit fly)





PR:Q7KVW5-8 small conductance calcium-activated potassium channel protein isoform H (fruit fly)





PR:Q9H2S1 small conductance calcium-activated potassium channel protein 2 (human)





PR:Q9H2S1-1 small conductance calcium-activated potassium channel protein 2 isoform 1 (human)





PR:Q9H2S1-2 small conductance calcium-activated potassium channel protein 2 isoform 2 (human)





PR:000000714 small conductance calcium-activated potassium channel protein 3





PR:000000773 small conductance calcium-activated potassium channel protein 3 isoform 1





PR:Q9UGI6-1 small conductance calcium-activated potassium channel protein 3 isoform 1 (human)





PR:P58391 small conductance calcium-activated potassium channel protein 3 (mouse)





PR:P70605 small conductance calcium-activated potassium channel protein 3 (rat)





PR:Q9UGI6 small conductance calcium-activated potassium channel protein 3 (human)





PR:000029956 small conductance calcium-activated potassium channel protein 3 sequence variant 1 (human)





PR:Q9UGI6-1 small conductance calcium-activated potassium channel protein 3 isoform 1 (human)





PR:Q9UGI6-2 small conductance calcium-activated potassium channel protein 3 isoform h2 (human)





PR:Q9UGI6-3 small conductance calcium-activated potassium channel protein 3 isoform h3 (human)