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family
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PR:000000668 |
calcium-activated calmodulin-binding potassium channel alpha subunit
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SMAD9/iso:3/Phos:1
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"A calcium-activated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. They are subunits of the small conductance calcium-activated channels. SK channels are independent of voltage and gated solely by intracellular calcium. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the calcium-binding protein calmodulin. Calmodulin binds to the SK channel through the Calmodulin binding domain (Pfam:PF02888), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when calcium binds the EF hands in the N-lobe of calmodulin. These channels play a crucial role in hyperpolarizing the membrane potential of excitable and nonexcitable cells." [PMID:10026195, PMID:11323678]
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gene
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PR:000000700 |
intermediate conductance calcium-activated potassium channel protein 4
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KCNN4
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"A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels." [PMID:9326665, PMID:9407042]
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organism-gene
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PR:O15554 |
intermediate conductance calcium-activated potassium channel protein 4 (human)
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hKCNN4
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"An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human." []
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Yes |
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organism-sequence
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PR:O15554-1 |
intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
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hKCNN4/iso:1
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"An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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organism-modification
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PR:000071778 |
intermediate conductance calcium-activated potassium channel protein 4 deaminated 1 (human)
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hKCNN4/Deam:1
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"An intermediate conductance calcium-activated potassium channel protein 4 (human) that has been deaminated on the residue at the position equivalent to Gln-382 of the amino acid sequence represented by UniProtKB:O15554. UniProtKB:O15554, Gln-382, MOD:00685." [IEDB_epitope:1731235, PRO:DNx]
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organism-gene
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PR:O89109 |
intermediate conductance calcium-activated potassium channel protein 4 (mouse)
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mKCNN4
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"An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of mouse." [OMA:O89109, PRO:DNx]
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organism-sequence
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PR:O89109-1 |
intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
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mKCNN4/iso:1
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"An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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organism-gene
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PR:Q9QYW1 |
intermediate conductance calcium-activated potassium channel protein 4 (rat)
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rKCNN4
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"An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of rat." [OMA:Q9QYW1, PRO:DNx]
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sequence
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PR:000000753 |
intermediate conductance calcium-activated potassium channel protein 4 isoform 1
|
KCNN4/iso:1
|
"An intermediate conductance calcium-activated potassium channel protein 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15554-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:O15554-1 |
intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
|
hKCNN4/iso:1
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"An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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organism-sequence
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PR:O89109-1 |
intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
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mKCNN4/iso:1
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"An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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gene
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PR:000000712 |
small conductance calcium-activated potassium channel protein 1
|
KCNN1
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"A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN1 gene or a 1:1 ortholog thereof." [PRO:CNA]
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PR:000000761 |
small conductance calcium-activated potassium channel protein 1 isoform 1
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PR:000002605 |
small conductance calcium-activated potassium channel protein 1 isoform 1 unmodified form
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organism-sequence
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PR:Q9EQR3-1 |
small conductance calcium-activated potassium channel protein 1 isoform 1 (mouse)
|
mKCNN1/iso:1
|
"A small conductance calcium-activated potassium channel protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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PR:000000762 |
small conductance calcium-activated potassium channel protein 1 isoform 2
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organism-sequence
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PR:Q92952-2 |
small conductance calcium-activated potassium channel protein 1 isoform 2 (human)
|
hKCNN1/iso:2
|
"A small conductance calcium-activated potassium channel protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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PR:000000763 |
small conductance calcium-activated potassium channel protein 1 isoform I
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organism-sequence
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PR:Q9EQR3-2 |
small conductance calcium-activated potassium channel protein 1 isoform 2 (mouse)
|
mKCNN1/iso:2
|
"A small conductance calcium-activated potassium channel protein 1 isoform I that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
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PR:000000764 |
small conductance calcium-activated potassium channel protein 1 isoform II
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organism-sequence
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PR:Q9EQR3-9 |
small conductance calcium-activated potassium channel protein 1 isoform II (mouse)
|
mKCNN1/iso:II
|
"A small conductance calcium-activated potassium channel protein 1 isoform II that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
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Yes |
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PR:000000765 |
small conductance calcium-activated potassium channel protein 1 isoform III
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organism-sequence
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PR:Q9EQR3-8 |
small conductance calcium-activated potassium channel protein 1 isoform III (mouse)
|
mKCNN1/iso:III
|
"A small conductance calcium-activated potassium channel protein 1 isoform III that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
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Yes |
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PR:000000766 |
small conductance calcium-activated potassium channel protein 1 isoform IV
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organism-sequence
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PR:Q9EQR3-7 |
small conductance calcium-activated potassium channel protein 1 isoform IV (mouse)
|
mKCNN1/iso:IV
|
"A small conductance calcium-activated potassium channel protein 1 isoform IV that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
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Yes |
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PR:000000767 |
small conductance calcium-activated potassium channel protein 1 isoform V
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organism-sequence
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PR:Q9EQR3-3 |
small conductance calcium-activated potassium channel protein 1 isoform V (mouse)
|
mKCNN1/iso:V
|
"A small conductance calcium-activated potassium channel protein 1 isoform V that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
|
Yes |
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PR:000000768 |
small conductance calcium-activated potassium channel protein 1 isoform VI
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organism-sequence
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PR:Q9EQR3-4 |
small conductance calcium-activated potassium channel protein 1 isoform VI (mouse)
|
mKCNN1/iso:VI
|
"A small conductance calcium-activated potassium channel protein 1 isoform VI that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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PR:000000769 |
small conductance calcium-activated potassium channel protein 1 isoform VII
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organism-sequence
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PR:Q9EQR3-5 |
small conductance calcium-activated potassium channel protein 1 isoform VII (mouse)
|
mKCNN1/iso:VII
|
"A small conductance calcium-activated potassium channel protein 1 isoform VII that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
|
Yes |
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PR:000000770 |
small conductance calcium-activated potassium channel protein 1 isoform VIII
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organism-sequence
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PR:Q9EQR3-6 |
small conductance calcium-activated potassium channel protein 1 isoform VIII (mouse)
|
mKCNN1/iso:VIII
|
"A small conductance calcium-activated potassium channel protein 1 isoform VIII that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
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Yes |
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organism-gene
|
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PR:P70606 |
small conductance calcium-activated potassium channel protein 1 (rat)
|
rKCNN1
|
"A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of rat." [PRO:CNA]
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organism-gene
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PR:Q92952 |
small conductance calcium-activated potassium channel protein 1 (human)
|
hKCNN1
|
"A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q92952]
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organism-sequence
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PR:Q92952-1 |
small conductance calcium-activated potassium channel protein 1 isoform h1 (human)
|
hKCNN1/iso:h1
|
"A small conductance calcium-activated potassium channel protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92952-1." [PRO:DNx, UniProtKB:Q92952]
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organism-sequence
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PR:Q92952-2 |
small conductance calcium-activated potassium channel protein 1 isoform 2 (human)
|
hKCNN1/iso:2
|
"A small conductance calcium-activated potassium channel protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
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organism-modification
|
|
PR:000084864 |
small conductance calcium-activated potassium channel protein 1 phosphorylated 1 (human)
|
hKCNN1/Phos:1
|
"A small conductance calcium-activated potassium channel protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-402 of the amino acid sequence represented by UniProtKB:Q92952-1. Example: UniProtKB:Q92952-1, Thr-402, MOD:00047." [IEDB_epitope:1352471, PRO:DNx]
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organism-gene
|
|
PR:Q9EQR3 |
small conductance calcium-activated potassium channel protein 1 (mouse)
|
mKCNN1
|
"A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of mouse." [PRO:CNA]
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organism-sequence
|
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PR:Q9EQR3-1 |
small conductance calcium-activated potassium channel protein 1 isoform 1 (mouse)
|
mKCNN1/iso:1
|
"A small conductance calcium-activated potassium channel protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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organism-sequence
|
|
PR:Q9EQR3-2 |
small conductance calcium-activated potassium channel protein 1 isoform 2 (mouse)
|
mKCNN1/iso:2
|
"A small conductance calcium-activated potassium channel protein 1 isoform I that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
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organism-sequence
|
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PR:Q9EQR3-3 |
small conductance calcium-activated potassium channel protein 1 isoform V (mouse)
|
mKCNN1/iso:V
|
"A small conductance calcium-activated potassium channel protein 1 isoform V that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
|
Yes |
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organism-sequence
|
|
PR:Q9EQR3-4 |
small conductance calcium-activated potassium channel protein 1 isoform VI (mouse)
|
mKCNN1/iso:VI
|
"A small conductance calcium-activated potassium channel protein 1 isoform VI that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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|
organism-sequence
|
|
PR:Q9EQR3-5 |
small conductance calcium-activated potassium channel protein 1 isoform VII (mouse)
|
mKCNN1/iso:VII
|
"A small conductance calcium-activated potassium channel protein 1 isoform VII that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
|
Yes |
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|
organism-sequence
|
|
PR:Q9EQR3-6 |
small conductance calcium-activated potassium channel protein 1 isoform VIII (mouse)
|
mKCNN1/iso:VIII
|
"A small conductance calcium-activated potassium channel protein 1 isoform VIII that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
|
Yes |
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|
organism-sequence
|
|
PR:Q9EQR3-7 |
small conductance calcium-activated potassium channel protein 1 isoform IV (mouse)
|
mKCNN1/iso:IV
|
"A small conductance calcium-activated potassium channel protein 1 isoform IV that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
|
Yes |
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|
organism-sequence
|
|
PR:Q9EQR3-8 |
small conductance calcium-activated potassium channel protein 1 isoform III (mouse)
|
mKCNN1/iso:III
|
"A small conductance calcium-activated potassium channel protein 1 isoform III that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
|
Yes |
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organism-sequence
|
|
PR:Q9EQR3-9 |
small conductance calcium-activated potassium channel protein 1 isoform II (mouse)
|
mKCNN1/iso:II
|
"A small conductance calcium-activated potassium channel protein 1 isoform II that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9EQR3]
|
Yes |
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PR:000000713 |
small conductance calcium-activated potassium channel protein 2
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PR:000000771 |
small conductance calcium-activated potassium channel protein 2 isoform 1
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PR:P58390-1 |
small conductance calcium-activated potassium channel protein 2 isoform 1 (mouse)
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PR:Q9H2S1-1 |
small conductance calcium-activated potassium channel protein 2 isoform 1 (human)
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| | |
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PR:000000772 |
small conductance calcium-activated potassium channel protein 2 isoform 2
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PR:Q9H2S1-2 |
small conductance calcium-activated potassium channel protein 2 isoform 2 (human)
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PR:000035381 |
small conductance calcium-activated potassium channel protein 2 isoform 3
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PR:B4YDY0 |
small conductance calcium-activated potassium channel protein 2 isoform 3 (mouse)
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| | |
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PR:P58390 |
small conductance calcium-activated potassium channel protein 2 (mouse)
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PR:B4YDY0 |
small conductance calcium-activated potassium channel protein 2 isoform 3 (mouse)
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PR:P58390-1 |
small conductance calcium-activated potassium channel protein 2 isoform 1 (mouse)
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| | |
|
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PR:P70604 |
small conductance calcium-activated potassium channel protein 2 (rat)
|
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| | |
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PR:Q7KVW5 |
small conductance calcium-activated potassium channel protein (fruit fly)
|
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|
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PR:Q7KVW5-1 |
small conductance calcium-activated potassium channel protein isoform K (fruit fly)
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PR:Q7KVW5-2 |
small conductance calcium-activated potassium channel protein isoform J (fruit fly)
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|
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PR:Q7KVW5-4 |
small conductance calcium-activated potassium channel protein isoform L (fruit fly)
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|
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|
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PR:Q7KVW5-5 |
small conductance calcium-activated potassium channel protein isoform M (fruit fly)
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|
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|
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PR:Q7KVW5-6 |
small conductance calcium-activated potassium channel protein isoform N (fruit fly)
|
|
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|
|
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PR:Q7KVW5-7 |
small conductance calcium-activated potassium channel protein isoform I (fruit fly)
|
|
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PR:Q7KVW5-8 |
small conductance calcium-activated potassium channel protein isoform H (fruit fly)
|
|
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|
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| | |
|
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PR:Q9H2S1 |
small conductance calcium-activated potassium channel protein 2 (human)
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|
|
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PR:Q9H2S1-1 |
small conductance calcium-activated potassium channel protein 2 isoform 1 (human)
|
|
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|
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| | | | | | | | |
|
|
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PR:Q9H2S1-2 |
small conductance calcium-activated potassium channel protein 2 isoform 2 (human)
|
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| | | | |
|
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PR:000000714 |
small conductance calcium-activated potassium channel protein 3
|
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| | |
|
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PR:000000773 |
small conductance calcium-activated potassium channel protein 3 isoform 1
|
|
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PR:Q9UGI6-1 |
small conductance calcium-activated potassium channel protein 3 isoform 1 (human)
|
|
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| | |
|
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PR:P58391 |
small conductance calcium-activated potassium channel protein 3 (mouse)
|
|
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| | |
|
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PR:P70605 |
small conductance calcium-activated potassium channel protein 3 (rat)
|
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| | |
|
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PR:Q9UGI6 |
small conductance calcium-activated potassium channel protein 3 (human)
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PR:000029956 |
small conductance calcium-activated potassium channel protein 3 sequence variant 1 (human)
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|
|
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PR:Q9UGI6-1 |
small conductance calcium-activated potassium channel protein 3 isoform 1 (human)
|
|
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|
|
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PR:Q9UGI6-2 |
small conductance calcium-activated potassium channel protein 3 isoform h2 (human)
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|
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PR:Q9UGI6-3 |
small conductance calcium-activated potassium channel protein 3 isoform h3 (human)
|
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|
