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family
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PR:000000674 |
cyclic nucleotide-gated channel beta subunit
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CATSPERB
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"A cyclic nucleotide-regulated channel protein that is the modulatory subunit of the cyclic nucleotide-gated channel (CNG channel). It consists of amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The carboxy-terminal region contains the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) and a region connecting the CNBD to the S6 segment (C-linker), which is important for modulation by transition metals. CNG beta subunits combine with the alpha subunits to form the cyclic nucleotide-gated ion channels, which mediate sensory transduction in photoreceptors and olfactory sensory neurons. These channels are likely composed of four subunits around a centrally located ion-permeable pore that opens in response to the direct binding of intracellular cyclic nucleotides. CNG channels are non-selective cation channels. They are not gated by membrane voltage although their structure includes the transmembrane S4 motif known to function as the membrane voltage sensor in all voltage-gated ion channels, but it has been shown to be important for proper folding and processing. Alpha and beta subunits of the CNG channel are very similar, however the beta subunits are not able to form functional channels by themselves." [PRO:CNA]
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gene
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PR:000000697 |
cyclic nucleotide-gated cation channel beta-3
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CNGB3
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"A cyclic nucleotide-gated channel beta subunit that is a translation product of the human CNGB3 gene or a 1:1 ortholog thereof. Many members of this class are subunits of the cone cyclic nucleotide-gated cation channel, which generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA]
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organism-gene
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PR:Q9JJZ9 |
cyclic nucleotide-gated cation channel beta-3 (mouse)
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mCNGB3
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"A cyclic nucleotide-gated cation channel beta-3 that is encoded in the genome of mouse." [OMA:Q9JJZ9, PRO:DNx]
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organism-sequence
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PR:Q9JJZ9-1 |
cyclic nucleotide-gated cation channel beta-3 isoform 1 (mouse)
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mCNGB3/iso:1
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"A cyclic nucleotide-gated cation channel beta-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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organism-gene
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PR:Q9NQW8 |
cyclic nucleotide-gated cation channel beta-3 (human)
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hCNGB3
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"A cyclic nucleotide-gated cation channel beta-3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NQW8]
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organism-sequence
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PR:000000752 |
cyclic nucleotide-gated cation channel beta-3 sequence variant S435F (human)
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hCNGB3/var:S435F
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"A cyclic nucleotide-gated cation channel beta-3 (human) that has a Phe residue at the position equivalent to Ser-435 of the amino acid sequence represented by UniProtKB:Q9NQW8-1. Example: UniProtKB:Q9NQW8-1, Ser-435, CHEBI:29997." [PMID:10888875, PMID:10958649, PRO:CNA, PRO:DAN]
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Yes |
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organism-sequence
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PR:Q9NQW8-1 |
cyclic nucleotide-gated cation channel beta-3 isoform 1 (human)
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hCNGB3/iso:1
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"A cyclic nucleotide-gated cation channel beta-3 isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NQW8]
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organism-sequence
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PR:Q9NQW8-2 |
cyclic nucleotide-gated cation channel beta-3 isoform 2 (human)
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hCNGB3/iso:2
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"A cyclic nucleotide-gated cation channel beta-3 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NQW8]
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sequence
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PR:000000749 |
cyclic nucleotide-gated cation channel beta-3 isoform 1
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CNGB3/iso:1
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"A cyclic nucleotide-gated cation channel beta-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJZ9-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:Q9JJZ9-1 |
cyclic nucleotide-gated cation channel beta-3 isoform 1 (mouse)
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mCNGB3/iso:1
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"A cyclic nucleotide-gated cation channel beta-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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sequence
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PR:000000750 |
cyclic nucleotide-gated cation channel beta-3 isoform 2
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CNGB3/iso:2
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"A cyclic nucleotide-gated cation channel beta-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NQW8-2 or a 1:1 ortholog thereof." [PMID:10888875, PRO:CNA, PRO:DAN]
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organism-sequence
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PR:Q9NQW8-2 |
cyclic nucleotide-gated cation channel beta-3 isoform 2 (human)
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hCNGB3/iso:2
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"A cyclic nucleotide-gated cation channel beta-3 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NQW8]
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sequence
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PR:000000751 |
cyclic nucleotide-gated cation channel beta-3 isoform 3
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CNGB3/iso:3
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"A cyclic nucleotide-gated cation channel beta-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NQW8-1 or a 1:1 ortholog thereof." [PMID:10958649, PRO:CNA, PRO:DAN]
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organism-sequence
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PR:Q9NQW8-1 |
cyclic nucleotide-gated cation channel beta-3 isoform 1 (human)
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hCNGB3/iso:1
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"A cyclic nucleotide-gated cation channel beta-3 isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NQW8]
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gene
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PR:000005632 |
cyclic nucleotide-gated cation channel beta-1
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CNGB1
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"A cyclic nucleotide-gated channel beta subunit that is a translation product of the human CNGB1 gene or a 1:1 ortholog thereof." [PRO:DNx]
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organism-gene
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PR:Q14028 |
cyclic nucleotide-gated cation channel beta-1 (human)
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hCNGB1
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"A cyclic nucleotide-gated cation channel beta-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14028]
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organism-sequence
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PR:Q14028-1 |
cyclic nucleotide-gated cation channel beta-1 isoform hRCNC2B (human)
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hCNGB1/iso:hRCNC2B
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"A cyclic nucleotide-gated cation channel beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14028-1." [PRO:DNx, UniProtKB:Q14028]
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organism-sequence
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PR:Q14028-2 |
cyclic nucleotide-gated cation channel beta-1 isoform hRCNC2A (human)
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hCNGB1/iso:hRCNC2A
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"A cyclic nucleotide-gated cation channel beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14028-2." [PRO:DNx, UniProtKB:Q14028]
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organism-sequence
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PR:Q14028-3 |
cyclic nucleotide-gated cation channel beta-1 isoform hGARP2 (human)
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hCNGB1/iso:hGARP2
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"A cyclic nucleotide-gated cation channel beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14028-3." [PRO:DNx, UniProtKB:Q14028]
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organism-sequence
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PR:Q14028-4 |
cyclic nucleotide-gated cation channel beta-1 isoform h4 (human)
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hCNGB1/iso:h4
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"A cyclic nucleotide-gated cation channel beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14028-4." [PRO:DNx, UniProtKB:Q14028]
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organism-modification
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PR:000065272 |
cyclic nucleotide-gated cation channel beta-1 deaminated 1 (human)
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hCNGB1/Deam:1
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"A cyclic nucleotide-gated cation channel beta-1 (human) that has been deaminated on the residue at the position equivalent to Gln-1003 of the amino acid sequence represented by UniProtKB:Q14028-1. Example: UniProtKB:Q14028-1, Gln-1003, MOD:00685." [IEDB_epitope:1855197, PRO:DNx]
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organism-modification
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PR:000068737 |
cyclic nucleotide-gated cation channel beta-1 phosphorylated 1 (human)
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hCNGB1/Phos:1
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"A cyclic nucleotide-gated cation channel beta-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-845 of the amino acid sequence represented by UniProtKB:Q14028-1. Example: UniProtKB:Q14028-1, Thr-845, MOD:00047." [IEDB_epitope:2145906, PRO:DNx]
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organism-modification
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PR:000071055 |
cyclic nucleotide-gated cation channel beta-1 phosphorylated 2 (human)
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hCNGB1/Phos:2
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"A cyclic nucleotide-gated cation channel beta-1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-735 of the amino acid sequence represented by UniProtKB:Q14028-1. Example: UniProtKB:Q14028-1, Ser-735, MOD:00046." [IEDB_epitope:2147205, PRO:DNx]
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organism-gene
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PR:Q39128 |
potassium channel KAT1 (Arabidopsis thaliana)
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At-CNGB1
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"A cyclic nucleotide-gated cation channel beta-1 that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]
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