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Protein Ontology report - platelet-derived growth factor with CUB domain
PR:000000675 - http://purl.obolibrary.org/obo/PR_000000675
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000675   
  PRO nameplatelet-derived growth factor with CUB domain 
  Definition"A protein that has a core domain composition consisting of a signal peptide, a CUB domain (Pfam:PF00431), and a C-terminal Platelet-derived growth factor (PDGF) domain (Pfam:PF00341)." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 7                                        
         Sequence3                                                  Organism-Sequence 12                                        
         Modification5                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038533
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
family



PR:000000675

platelet-derived growth factor with CUB domain

CATSPERB


"A protein that has a core domain composition consisting of a signal peptide, a CUB domain (Pfam:PF00431), and a C-terminal Platelet-derived growth factor (PDGF) domain (Pfam:PF00341)." [PRO:CNA]


gene



PR:000000703

platelet-derived growth factor C

PDGFC


"A platelet-derived growth factor with CUB domain that is a translation product of the human PDGFC gene or a 1:1 ortholog thereof. Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling." [PRO:CNA]


organism-gene



PR:Q8CI19

platelet-derived growth factor C (mouse)

mPDGFC


"A platelet-derived growth factor C that is encoded in the genome of mouse." [OMA:Q8CI19, PRO:DNx]


organism-sequence



PR:Q8CI19-1

platelet-derived growth factor C isoform 1 (mouse)

mPDGFC/iso:1


"A platelet-derived growth factor C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036571

platelet-derived growth factor C isoform 1 cleaved 1 (mouse)

mPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in mouse. UniProtKB:Q8CI19-1, 226-345." [PMID:11297552, PMID:15372073, PRO:CNA]

Yes

organism-gene



PR:Q9EQX6

platelet-derived growth factor C (rat)

rPDGFC


"A platelet-derived growth factor C that is encoded in the genome of rat." [OMA:Q9EQX6, PRO:DNx]


organism-gene



PR:Q9I946

platelet-derived growth factor C (chicken)

chick-PDGFC


"A platelet-derived growth factor C that is encoded in the genome of chicken." [OMA:Q9I946, PRO:DNx]


organism-gene



PR:Q9NRA1

platelet-derived growth factor C (human)

hPDGFC


"A platelet-derived growth factor C that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NRA1]


organism-sequence



PR:Q9NRA1-1

platelet-derived growth factor C isoform 1 (human)

hPDGFC/iso:1


"A platelet-derived growth factor C isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036570

platelet-derived growth factor C isoform 1 cleaved 1 (human)

hPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in human. UniProtKB:Q9NRA1-1, 226-345." [PMID:10806482, PMID:11297552, PMID:15911618, PRO:CNA]

Yes

organism-modification



PR:000036572

platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)

hPDGFC/iso:1/Sumo1+


"A platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form in human. UniProtKB:Q9NRA1-1, MOD:01149~PR:000050074." [PMID:16443219, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000063004

platelet-derived growth factor C isoform 1, signal peptide removed form (human)

hPDGFC/iso:1/SigPep-


"A platelet-derived growth factor C isoform 1 (human) that has had the signal peptide removed. UniProtKB:Q9NRA1-1, 23-345." [PRO:DNx, Reactome:R-HSA-381905]


organism-sequence



PR:Q9NRA1-2

platelet-derived growth factor C isoform h2 (human)

hPDGFC/iso:h2


"A platelet-derived growth factor C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRA1-2." [PRO:DNx, UniProtKB:Q9NRA1]


organism-sequence



PR:Q9NRA1-3

platelet-derived growth factor C isoform h3 (human)

hPDGFC/iso:h3


"A platelet-derived growth factor C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRA1-3." [PRO:DNx, UniProtKB:Q9NRA1]


organism-sequence



PR:Q9NRA1-4

platelet-derived growth factor C isoform h4 (human)

hPDGFC/iso:h4


"A platelet-derived growth factor C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRA1-4." [PRO:DNx, UniProtKB:Q9NRA1]


sequence



PR:000000754

platelet-derived growth factor C isoform 1

PDGFC/iso:1


"A platelet-derived growth factor C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRA1-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8CI19-1

platelet-derived growth factor C isoform 1 (mouse)

mPDGFC/iso:1


"A platelet-derived growth factor C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036571

platelet-derived growth factor C isoform 1 cleaved 1 (mouse)

mPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in mouse. UniProtKB:Q8CI19-1, 226-345." [PMID:11297552, PMID:15372073, PRO:CNA]

Yes

organism-sequence



PR:Q9NRA1-1

platelet-derived growth factor C isoform 1 (human)

hPDGFC/iso:1


"A platelet-derived growth factor C isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036570

platelet-derived growth factor C isoform 1 cleaved 1 (human)

hPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in human. UniProtKB:Q9NRA1-1, 226-345." [PMID:10806482, PMID:11297552, PMID:15911618, PRO:CNA]

Yes

organism-modification



PR:000036572

platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)

hPDGFC/iso:1/Sumo1+


"A platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form in human. UniProtKB:Q9NRA1-1, MOD:01149~PR:000050074." [PMID:16443219, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000063004

platelet-derived growth factor C isoform 1, signal peptide removed form (human)

hPDGFC/iso:1/SigPep-


"A platelet-derived growth factor C isoform 1 (human) that has had the signal peptide removed. UniProtKB:Q9NRA1-1, 23-345." [PRO:DNx, Reactome:R-HSA-381905]


modification



PR:000000934

platelet-derived growth factor C isoform 1 sumoylated form

PDGFC/iso:1/SumoLys+


"A platelet-derived growth factor C isoform 1 that includes at least one sumoylated lysine." [PRO:CNA]


modification



PR:000000983

platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form

PDGFC/iso:1/Sumo1+


"A platelet-derived growth factor C isoform 1 sumoylated form in which the sumoylation conjugate is SUMO1. Example: UniProtKB:Q9NRA1-1, Lys-314, MOD:01149~PR:000050074." [PMID:16443219, PRO:CNA, PRO:DAN]


organism-modification



PR:000036572

platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)

hPDGFC/iso:1/Sumo1+


"A platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form in human. UniProtKB:Q9NRA1-1, MOD:01149~PR:000050074." [PMID:16443219, PRO:CNA, PRO:DAN]

Yes

modification



PR:000021917

platelet-derived growth factor C isoform 1, signal peptide removed form

PDGFC/iso:1/SigPep-


"A platelet-derived growth factor C isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000982

platelet-derived growth factor C isoform 1 cleaved 1

PDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1, signal peptide removed form that has been processed by subsequent removal of the CUB domain." [PRO:CNA]


organism-modification



PR:000036570

platelet-derived growth factor C isoform 1 cleaved 1 (human)

hPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in human. UniProtKB:Q9NRA1-1, 226-345." [PMID:10806482, PMID:11297552, PMID:15911618, PRO:CNA]

Yes

organism-modification



PR:000036571

platelet-derived growth factor C isoform 1 cleaved 1 (mouse)

mPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in mouse. UniProtKB:Q8CI19-1, 226-345." [PMID:11297552, PMID:15372073, PRO:CNA]

Yes

modification



PR:000018298

platelet-derived growth factor C proteolytic cleavage product

PDGFC/ClvPrd


"A platelet-derived growth factor C that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000982

platelet-derived growth factor C isoform 1 cleaved 1

PDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1, signal peptide removed form that has been processed by subsequent removal of the CUB domain." [PRO:CNA]


organism-modification



PR:000036570

platelet-derived growth factor C isoform 1 cleaved 1 (human)

hPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in human. UniProtKB:Q9NRA1-1, 226-345." [PMID:10806482, PMID:11297552, PMID:15911618, PRO:CNA]

Yes

organism-modification



PR:000036571

platelet-derived growth factor C isoform 1 cleaved 1 (mouse)

mPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in mouse. UniProtKB:Q8CI19-1, 226-345." [PMID:11297552, PMID:15372073, PRO:CNA]

Yes

gene



PR:000000704

platelet-derived growth factor D

PDGFD


"A platelet-derived growth factor with CUB domain that is a translation product of the human PDGFD gene or a 1:1 ortholog thereof. Potent mitogen for cells of mesenchymal origin." [PRO:CNA]


organism-gene



PR:Q925I7

platelet-derived growth factor D (mouse)

mPDGFD


"A platelet-derived growth factor D that is encoded in the genome of mouse." [OMA:Q925I7, PRO:DNx]


organism-sequence



PR:Q925I7-1

platelet-derived growth factor D isoform 1 (mouse)

mPDGFD/iso:1


"A platelet-derived growth factor D isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q925I7-2

platelet-derived growth factor D isoform 2 (mouse)

mPDGFD/iso:2


"A platelet-derived growth factor D isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q925I7-3

platelet-derived growth factor D isoform m3 (mouse)

mPDGFD/iso:m3


"A platelet-derived growth factor D (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q925I7-3." [PRO:DNx, UniProtKB:Q925I7]


organism-gene



PR:Q9EQT1

platelet-derived growth factor D (rat)

rPDGFD


"A platelet-derived growth factor D that is encoded in the genome of rat." [OMA:Q9EQT1, PRO:DNx]


organism-sequence



PR:Q9EQT1-1

platelet-derived growth factor D isoform 1 (rat)

rPDGFD/iso:1


"A platelet-derived growth factor D isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9EQT1-2

platelet-derived growth factor D isoform 2 (rat)

rPDGFD/iso:2


"A platelet-derived growth factor D isoform 2 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q9GZP0

platelet-derived growth factor D (human)

hPDGFD


"A platelet-derived growth factor D that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9GZP0]


organism-sequence



PR:Q9GZP0-1

platelet-derived growth factor D isoform 1 (human)

hPDGFD/iso:1


"A platelet-derived growth factor D isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9GZP0-2

platelet-derived growth factor D isoform 2 (human)

hPDGFD/iso:2


"A platelet-derived growth factor D isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000048722

platelet-derived growth factor D, signal peptide removed form (human)

hPDGFD/SigPep-


"A platelet-derived growth factor D (human) that has had the signal peptide removed. UniProtKB:Q9GZP0, 19-370." [PRO:DNx, Reactome:R-HSA-381906]


organism-modification



PR:000058048

platelet-derived growth factor D O-glycosylated 1 (human)

hPDGFD/OGlyco:1


"A platelet-derived growth factor D (human) that has been O-glycosylated at the residue equivalent to Ser-189 of the amino acid sequence represented by UniProtKB:Q9GZP0-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q9GZP0-1, Ser-189, MOD:00002~GNO:G53434XO." [GlyGen:Q9GZP0-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000058049

platelet-derived growth factor D O-glycosylated 2 (human)

hPDGFD/OGlyco:2


"A platelet-derived growth factor D (human) that has been O-glycosylated at the residue equivalent to Ser-197 of the amino acid sequence represented by UniProtKB:Q9GZP0-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q9GZP0-1, Ser-197, MOD:00002~GNO:G43417UB." [GlyGen:Q9GZP0-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000058050

platelet-derived growth factor D O-glycosylated 3 (human)

hPDGFD/OGlyco:3


"A platelet-derived growth factor D (human) that has been O-glycosylated at the residue equivalent to Thr-201 of the amino acid sequence represented by UniProtKB:Q9GZP0-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q9GZP0-1, Thr-201, MOD:00005~GNO:G29068FM." [GlyGen:Q9GZP0-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000058051

platelet-derived growth factor D O-glycosylated 4 (human)

hPDGFD/OGlyco:4


"A platelet-derived growth factor D (human) that has been O-glycosylated at the residue equivalent to Thr-201 of the amino acid sequence represented by UniProtKB:Q9GZP0-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q9GZP0-1, Thr-201, MOD:00005~GNO:G43417UB." [GlyGen:Q9GZP0-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000058052

platelet-derived growth factor D O-glycosylated 5 (human)

hPDGFD/OGlyco:5


"A platelet-derived growth factor D (human) that has been O-glycosylated at the residue equivalent to Thr-24 of the amino acid sequence represented by UniProtKB:Q9GZP0-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q9GZP0-1, Thr-24, MOD:00005~GNO:G43417UB." [GlyGen:Q9GZP0-1, PMID:30459171, PRO:DNx]


sequence



PR:000043176

platelet-derived growth factor D isoform 1

PDGFD/iso:1


"A platelet-derived growth factor D that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GZP0-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q925I7-1

platelet-derived growth factor D isoform 1 (mouse)

mPDGFD/iso:1


"A platelet-derived growth factor D isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9EQT1-1

platelet-derived growth factor D isoform 1 (rat)

rPDGFD/iso:1


"A platelet-derived growth factor D isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9GZP0-1

platelet-derived growth factor D isoform 1 (human)

hPDGFD/iso:1


"A platelet-derived growth factor D isoform 1 that is encoded in the genome of human." [PRO:DNx]


sequence



PR:000043177

platelet-derived growth factor D isoform 2

PDGFD/iso:2


"A platelet-derived growth factor D that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GZP0-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q925I7-2

platelet-derived growth factor D isoform 2 (mouse)

mPDGFD/iso:2


"A platelet-derived growth factor D isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9EQT1-2

platelet-derived growth factor D isoform 2 (rat)

rPDGFD/iso:2


"A platelet-derived growth factor D isoform 2 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9GZP0-2

platelet-derived growth factor D isoform 2 (human)

hPDGFD/iso:2


"A platelet-derived growth factor D isoform 2 that is encoded in the genome of human." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036570 hPDGFC/iso:1/Clv:1
UniProtKB:Q9NRA1-1, 226-345
enablesGO:0005102 signaling receptor binding PMID:10806482; PMID:11297552
GO:0008083 growth factor activity PMID:10806482; PMID:11297552
located_inGO:0005615 extracellular space PMID:15911618
PR:000036571 mPDGFC/iso:1/Clv:1
UniProtKB:Q8CI19-1, 226-345
acts_upstream_of_or_withinGO:0042060 wound healing PMID:11297552
located_inGO:0005615 extracellular space PMID:15372073
PR:000036572 hPDGFC/iso:1/Sumo1+
UniProtKB:Q9NRA1-1, MOD:01149~PR:000050074
located_inGO:0005634 nucleus PMID:16443219