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Protein Ontology report - sodium leak channel NALCN
PR:000000678 - http://purl.obolibrary.org/obo/PR_000000678
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000678   
  PRO namesodium leak channel NALCN 
  Synonyms
PRO-Short-label: EXACT:NALCN
Gene-based: RELATED:VGCNL1
Other: EXACT:CanIon | sodium leak channel non-selective protein | voltage gated channel-like protein 1
  Definition"An ion channel protein that is a translation product of the human NALCN gene or a 1:1 ortholog thereof. The prototype subunit contains four copies of the six transmembrane ion transport protein domain, but the number of copies of this domain varies among splice variants. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. They are subunits of a voltage-independent, nonselective cation channel." [PMID:17448995, PRO:CNA] 
  CommentNote: NALCN operates as part of a complex with UNC80 (PR:000017098) and UNC79 (PR:000030850) that together form a fucntional channel. [PRO:DAN, PMID:21040849]. 
  PRO Categorygene 
  ParentPR:000049983 ion channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038547;IUPHARobj:750
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000678

sodium leak channel NALCN

NALCN


"An ion channel protein that is a translation product of the human NALCN gene or a 1:1 ortholog thereof. The prototype subunit contains four copies of the six transmembrane ion transport protein domain, but the number of copies of this domain varies among splice variants. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. They are subunits of a voltage-independent, nonselective cation channel." [PMID:17448995, PRO:CNA]

Yes

organism-gene



PR:Q6Q760

sodium leak channel NALCN (rat)

rNALCN


"A sodium leak channel NALCN that is encoded in the genome of rat." [OMA:Q6Q760, PRO:DNx]


organism-gene



PR:Q8BXR5

sodium leak channel NALCN (mouse)

mNALCN


"A sodium leak channel NALCN that is encoded in the genome of mouse." [OMA:Q8BXR5, PRO:DNx]


organism-sequence



PR:Q8BXR5-1

sodium leak channel NALCN isoform 1 (mouse)

mNALCN/iso:1


"A sodium leak channel NALCN isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q8BXR5-2

sodium leak channel NALCN isoform 2 (mouse)

mNALCN/iso:2


"A sodium leak channel NALCN isoform 3 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q8IZF0

sodium leak channel NALCN (human)

hNALCN


"A sodium leak channel NALCN that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8IZF0]


organism-sequence



PR:Q8IZF0-1

sodium leak channel NALCN isoform 1 (human)

hNALCN/iso:1


"A sodium leak channel NALCN isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8IZF0-2

sodium leak channel NALCN isoform 2 (human)

hNALCN/iso:2


"A sodium leak channel NALCN isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8IZF0-3

sodium leak channel NALCN isoform 3 (human)

hNALCN/iso:3


"A sodium leak channel NALCN isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000066671

sodium leak channel NALCN deaminated 1 (human)

hNALCN/Deam:1


"A sodium leak channel NALCN (human) that has been deaminated on the residue at the position equivalent to Asn-216 of the amino acid sequence represented by UniProtKB:Q8IZF0-1. Example: UniProtKB:Q8IZF0-1, Asn-216, MOD:00684." [IEDB_epitope:1331376, PRO:DNx]


organism-modification



PR:000083319

sodium leak channel NALCN phosphorylated 1 (human)

hNALCN/Phos:1


"A sodium leak channel NALCN (human) that has been phosphorylated on the residue at the position equivalent to Ser-1113 of the amino acid sequence represented by UniProtKB:Q8IZF0-1. Example: UniProtKB:Q8IZF0-1, Ser-1113, MOD:00046." [IEDB_epitope:1348675, PRO:DNx]


sequence



PR:000000715

sodium leak channel NALCN isoform 1

NALCN/iso:1


"A sodium leak channel NALCN that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IZF0-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8BXR5-1

sodium leak channel NALCN isoform 1 (mouse)

mNALCN/iso:1


"A sodium leak channel NALCN isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q8IZF0-1

sodium leak channel NALCN isoform 1 (human)

hNALCN/iso:1


"A sodium leak channel NALCN isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000716

sodium leak channel NALCN isoform 2

NALCN/iso:2


"A sodium leak channel NALCN that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IZF0-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8IZF0-2

sodium leak channel NALCN isoform 2 (human)

hNALCN/iso:2


"A sodium leak channel NALCN isoform 2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000717

sodium leak channel NALCN isoform 3

NALCN/iso:3


"A sodium leak channel NALCN that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IZF0-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8BXR5-2

sodium leak channel NALCN isoform 2 (mouse)

mNALCN/iso:2


"A sodium leak channel NALCN isoform 3 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q8IZF0-3

sodium leak channel NALCN isoform 3 (human)

hNALCN/iso:3


"A sodium leak channel NALCN isoform 3 that is encoded in the genome of human." [PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000678 NALCN
They are subunits of a voltage-independent, nonselective cation channel
acts_upstream_of_or_withinGO:0006811 monoatomic ion transport PIRSF:PIRSF038547
enablescontributes_to GO:0005216 monoatomic ion channel activity PIRSF:PIRSF038547