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Protein Ontology report - platelet-derived growth factor C
PR:000000703 - http://purl.obolibrary.org/obo/PR_000000703
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000703   
  PRO nameplatelet-derived growth factor C 
  Synonyms
PRO-Short-label: EXACT:PDGFC
Gene-based: RELATED:SCDGF | UNQ174/PRO200
Other: EXACT:fallotein | PDGF-C | spinal cord-derived growth factor | VEGF-E
  Definition"A platelet-derived growth factor with CUB domain that is a translation product of the human PDGFC gene or a 1:1 ortholog thereof. Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000675 platelet-derived growth factor with CUB domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification5                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000703

platelet-derived growth factor C

PDGFC


"A platelet-derived growth factor with CUB domain that is a translation product of the human PDGFC gene or a 1:1 ortholog thereof. Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling." [PRO:CNA]


organism-gene



PR:Q8CI19

platelet-derived growth factor C (mouse)

mPDGFC


"A platelet-derived growth factor C that is encoded in the genome of mouse." [OMA:Q8CI19, PRO:DNx]


organism-sequence



PR:Q8CI19-1

platelet-derived growth factor C isoform 1 (mouse)

mPDGFC/iso:1


"A platelet-derived growth factor C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036571

platelet-derived growth factor C isoform 1 cleaved 1 (mouse)

mPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in mouse. UniProtKB:Q8CI19-1, 226-345." [PMID:11297552, PMID:15372073, PRO:CNA]

Yes

organism-gene



PR:Q9EQX6

platelet-derived growth factor C (rat)

rPDGFC


"A platelet-derived growth factor C that is encoded in the genome of rat." [OMA:Q9EQX6, PRO:DNx]


organism-gene



PR:Q9I946

platelet-derived growth factor C (chicken)

chick-PDGFC


"A platelet-derived growth factor C that is encoded in the genome of chicken." [OMA:Q9I946, PRO:DNx]


organism-gene



PR:Q9NRA1

platelet-derived growth factor C (human)

hPDGFC


"A platelet-derived growth factor C that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NRA1]


organism-sequence



PR:Q9NRA1-1

platelet-derived growth factor C isoform 1 (human)

hPDGFC/iso:1


"A platelet-derived growth factor C isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036570

platelet-derived growth factor C isoform 1 cleaved 1 (human)

hPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in human. UniProtKB:Q9NRA1-1, 226-345." [PMID:10806482, PMID:11297552, PMID:15911618, PRO:CNA]

Yes

organism-modification



PR:000036572

platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)

hPDGFC/iso:1/Sumo1+


"A platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form in human. UniProtKB:Q9NRA1-1, MOD:01149~PR:000050074." [PMID:16443219, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000063004

platelet-derived growth factor C isoform 1, signal peptide removed form (human)

hPDGFC/iso:1/SigPep-


"A platelet-derived growth factor C isoform 1 (human) that has had the signal peptide removed. UniProtKB:Q9NRA1-1, 23-345." [PRO:DNx, Reactome:R-HSA-381905]


organism-sequence



PR:Q9NRA1-2

platelet-derived growth factor C isoform h2 (human)

hPDGFC/iso:h2


"A platelet-derived growth factor C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRA1-2." [PRO:DNx, UniProtKB:Q9NRA1]


organism-sequence



PR:Q9NRA1-3

platelet-derived growth factor C isoform h3 (human)

hPDGFC/iso:h3


"A platelet-derived growth factor C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRA1-3." [PRO:DNx, UniProtKB:Q9NRA1]


organism-sequence



PR:Q9NRA1-4

platelet-derived growth factor C isoform h4 (human)

hPDGFC/iso:h4


"A platelet-derived growth factor C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRA1-4." [PRO:DNx, UniProtKB:Q9NRA1]


sequence



PR:000000754

platelet-derived growth factor C isoform 1

PDGFC/iso:1


"A platelet-derived growth factor C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRA1-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8CI19-1

platelet-derived growth factor C isoform 1 (mouse)

mPDGFC/iso:1


"A platelet-derived growth factor C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036571

platelet-derived growth factor C isoform 1 cleaved 1 (mouse)

mPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in mouse. UniProtKB:Q8CI19-1, 226-345." [PMID:11297552, PMID:15372073, PRO:CNA]

Yes

organism-sequence



PR:Q9NRA1-1

platelet-derived growth factor C isoform 1 (human)

hPDGFC/iso:1


"A platelet-derived growth factor C isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036570

platelet-derived growth factor C isoform 1 cleaved 1 (human)

hPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in human. UniProtKB:Q9NRA1-1, 226-345." [PMID:10806482, PMID:11297552, PMID:15911618, PRO:CNA]

Yes

organism-modification



PR:000036572

platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)

hPDGFC/iso:1/Sumo1+


"A platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form in human. UniProtKB:Q9NRA1-1, MOD:01149~PR:000050074." [PMID:16443219, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000063004

platelet-derived growth factor C isoform 1, signal peptide removed form (human)

hPDGFC/iso:1/SigPep-


"A platelet-derived growth factor C isoform 1 (human) that has had the signal peptide removed. UniProtKB:Q9NRA1-1, 23-345." [PRO:DNx, Reactome:R-HSA-381905]


modification



PR:000000934

platelet-derived growth factor C isoform 1 sumoylated form

PDGFC/iso:1/SumoLys+


"A platelet-derived growth factor C isoform 1 that includes at least one sumoylated lysine." [PRO:CNA]


modification



PR:000000983

platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form

PDGFC/iso:1/Sumo1+


"A platelet-derived growth factor C isoform 1 sumoylated form in which the sumoylation conjugate is SUMO1. Example: UniProtKB:Q9NRA1-1, Lys-314, MOD:01149~PR:000050074." [PMID:16443219, PRO:CNA, PRO:DAN]


organism-modification



PR:000036572

platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)

hPDGFC/iso:1/Sumo1+


"A platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form in human. UniProtKB:Q9NRA1-1, MOD:01149~PR:000050074." [PMID:16443219, PRO:CNA, PRO:DAN]

Yes

modification



PR:000021917

platelet-derived growth factor C isoform 1, signal peptide removed form

PDGFC/iso:1/SigPep-


"A platelet-derived growth factor C isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000982

platelet-derived growth factor C isoform 1 cleaved 1

PDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1, signal peptide removed form that has been processed by subsequent removal of the CUB domain." [PRO:CNA]


organism-modification



PR:000036570

platelet-derived growth factor C isoform 1 cleaved 1 (human)

hPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in human. UniProtKB:Q9NRA1-1, 226-345." [PMID:10806482, PMID:11297552, PMID:15911618, PRO:CNA]

Yes

organism-modification



PR:000036571

platelet-derived growth factor C isoform 1 cleaved 1 (mouse)

mPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in mouse. UniProtKB:Q8CI19-1, 226-345." [PMID:11297552, PMID:15372073, PRO:CNA]

Yes

modification



PR:000018298

platelet-derived growth factor C proteolytic cleavage product

PDGFC/ClvPrd


"A platelet-derived growth factor C that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000982

platelet-derived growth factor C isoform 1 cleaved 1

PDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1, signal peptide removed form that has been processed by subsequent removal of the CUB domain." [PRO:CNA]


organism-modification



PR:000036570

platelet-derived growth factor C isoform 1 cleaved 1 (human)

hPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in human. UniProtKB:Q9NRA1-1, 226-345." [PMID:10806482, PMID:11297552, PMID:15911618, PRO:CNA]

Yes

organism-modification



PR:000036571

platelet-derived growth factor C isoform 1 cleaved 1 (mouse)

mPDGFC/iso:1/Clv:1


"A platelet-derived growth factor C isoform 1 cleaved 1 in mouse. UniProtKB:Q8CI19-1, 226-345." [PMID:11297552, PMID:15372073, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0042060 wound healingPR:000036571 mPDGFC/iso:1/Clv:1 PMID:11297552

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005102 signaling receptor bindingPR:000036570 hPDGFC/iso:1/Clv:1 PMID:10806482; PMID:11297552
GO:0008083 growth factor activityPR:000036570 hPDGFC/iso:1/Clv:1 PMID:10806482; PMID:11297552

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005615 extracellular spacePR:000036570 hPDGFC/iso:1/Clv:1 PMID:15911618
PR:000036571 mPDGFC/iso:1/Clv:1 PMID:15372073
GO:0005634 nucleusPR:000036572 hPDGFC/iso:1/Sumo1+ PMID:16443219