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Protein Ontology report - D(2)-like dopamine receptor
PR:000001108 - http://purl.obolibrary.org/obo/PR_000001108
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001108   
  PRO nameD(2)-like dopamine receptor 
  Definition"A dopamine receptor that is a product of the DRD2, DRD3, or DRD4 gene. The active form binds dopamine and its activity is mediated by G proteins that cause inhibition of adenylate cyclase." [PRO:WCB, Wikipedia:Dopamine_receptor] 
  PRO Categoryfamily 
  ParentPR:000044633 dopamine receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 12                                        
         Sequence4                                                  Organism-Sequence 26                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038553
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000001108 D(2)-like dopamine receptor
ALCAM

gene


PR:000001177 D(2) dopamine receptor
DRD2

organism-gene


PR:P14416 D(2) dopamine receptor (human)
hDRD2

organism-sequence


PR:P14416-1 D(2) dopamine receptor isoform 1 (human)
hDRD2/iso:1

organism-sequence


PR:P14416-2 D(2) dopamine receptor isoform 2 (human)
hDRD2/iso:2

organism-sequence


PR:P14416-3 D(2) dopamine receptor isoform h3 (human)
hDRD2/iso:h3

organism-gene


PR:P61168 D(2) dopamine receptor (mouse)
mDRD2

organism-sequence


PR:P61168-1 D(2) dopamine receptor isoform 1 (mouse)
mDRD2/iso:1
Yes
organism-sequence


PR:P61168-2 D(2) dopamine receptor isoform 2 (mouse)
mDRD2/iso:2
Yes
organism-gene


PR:P61169 D(2) dopamine receptor (rat)
rDRD2

organism-sequence


PR:P61169-1 D(2) dopamine receptor isoform Long (rat)
rDRD2/iso:Long

organism-sequence


PR:P61169-2 D(2) dopamine receptor isoform Short (rat)
rDRD2/iso:Short

organism-gene


PR:Q6RYS9 dopamine receptor 3 (worm)
DRD2 (worm)

organism-sequence


PR:Q6RYS9-1 dopamine receptor 3 isoform b (worm)
DRD2/iso:b (worm)

organism-sequence


PR:Q6RYS9-2 dopamine receptor 3 isoform a (worm)
DRD2/iso:a (worm)

organism-sequence


PR:Q6RYS9-3 dopamine receptor 3 isoform c (worm)
DRD2/iso:c (worm)

organism-sequence


PR:Q6RYS9-4 dopamine receptor 3 isoform d (worm)
DRD2/iso:d (worm)

organism-gene


PR:Q8IS44 dopamine D2-like receptor (fruit fly)
fly-DRD2

organism-sequence


PR:Q8IS44-1 dopamine D2-like receptor isoform H (fruit fly)
fly-DRD2/iso:H

organism-sequence


PR:Q8IS44-2 dopamine D2-like receptor isoform J (fruit fly)
fly-DRD2/iso:J

organism-sequence


PR:Q8IS44-3 dopamine D2-like receptor isoform F (fruit fly)
fly-DRD2/iso:F

organism-sequence


PR:Q8IS44-4 dopamine D2-like receptor isoform B (fruit fly)
fly-DRD2/iso:B

organism-sequence


PR:Q8IS44-5 dopamine D2-like receptor isoform G (fruit fly)
fly-DRD2/iso:G

organism-sequence


PR:Q8IS44-6 dopamine D2-like receptor isoform I (fruit fly)
fly-DRD2/iso:I

organism-gene


PR:Q9GJU1 D(2) dopamine receptor (dog)
dog-DRD2

sequence


PR:000037412 D(2) dopamine receptor isoform 1
DRD2/iso:1

organism-sequence


PR:P14416-1 D(2) dopamine receptor isoform 1 (human)
hDRD2/iso:1

organism-sequence


PR:P61168-1 D(2) dopamine receptor isoform 1 (mouse)
mDRD2/iso:1
Yes
sequence


PR:000037413 D(2) dopamine receptor isoform 2
DRD2/iso:2

organism-sequence


PR:P14416-2 D(2) dopamine receptor isoform 2 (human)
hDRD2/iso:2

organism-sequence


PR:P61168-2 D(2) dopamine receptor isoform 2 (mouse)
mDRD2/iso:2
Yes
gene


PR:000001178 D(3) dopamine receptor
DRD3

organism-gene


PR:P19020 D(3) dopamine receptor (rat)
rDRD3

organism-sequence


PR:P19020-1 D(3) dopamine receptor isoform 1 (rat)
rDRD3/iso:1

organism-sequence


PR:P19020-2 D(3) dopamine receptor isoform rD3(TM3-del) (rat)
rDRD3/iso:rD3(TM3-del)

organism-sequence


PR:P19020-3 D(3) dopamine receptor isoform rD3(O2-DEL) (rat)
rDRD3/iso:rD3(O2-DEL)

organism-gene


PR:P30728 D(3) dopamine receptor (mouse)
mDRD3

organism-sequence


PR:P30728-1 D(3) dopamine receptor isoform D3Long (mouse)
mDRD3/iso:D3Long

organism-sequence


PR:P30728-2 D(3) dopamine receptor isoform D3Short (mouse)
mDRD3/iso:D3Short
Yes
organism-gene


PR:P35462 D(3) dopamine receptor (human)
hDRD3

organism-sequence


PR:P35462-1 D(3) dopamine receptor isoform 1 (human)
hDRD3/iso:1

organism-sequence


PR:P35462-3 D(3) dopamine receptor isoform h3 (human)
hDRD3/iso:h3

organism-modification


PR:000069676 D(3) dopamine receptor phosphorylated 1 (human)
hDRD3/Phos:1

sequence


PR:000039260 D(3) dopamine receptor isoform 1
DRD3/iso:1

organism-sequence


PR:P19020-1 D(3) dopamine receptor isoform 1 (rat)
rDRD3/iso:1

organism-sequence


PR:P30728-1 D(3) dopamine receptor isoform D3Long (mouse)
mDRD3/iso:D3Long

gene


PR:000001179 D(4) dopamine receptor
DRD4

organism-gene


PR:P21917 D(4) dopamine receptor (human)
hDRD4

organism-gene


PR:P30729 D(4) dopamine receptor (rat)
rDRD4

organism-sequence


PR:P30729-1 D(4) dopamine receptor isoform 1 (rat)
rDRD4/iso:1

organism-gene


PR:P51436 D(4) dopamine receptor (mouse)
mDRD4

organism-sequence


PR:P51436-1 D(4) dopamine receptor isoform 1 (mouse)
mDRD4/iso:1

sequence


PR:000039659 D(4) dopamine receptor isoform 1
DRD4/iso:1

organism-sequence


PR:P30729-1 D(4) dopamine receptor isoform 1 (rat)
rDRD4/iso:1

organism-sequence


PR:P51436-1 D(4) dopamine receptor isoform 1 (mouse)
mDRD4/iso:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001975 response to amphetaminePR:P61168-2 mDRD2/iso:2 MGI_ref:3611062; PMID:12476322
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathwayPR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
GO:0007212 dopamine receptor signaling pathwayPR:P61168-1 mDRD2/iso:1 MGI_ref:2181304; PMID:11089973
GO:0007626 locomotory behaviorPR:P61168-1 mDRD2/iso:1 MGI_ref:1927281; PMID:11069937
GO:0014059 regulation of dopamine secretionPR:P61168-2 mDRD2/iso:2 MGI_ref:3655899; PMID:11943831
GO:0032228 regulation of synaptic transmission, GABAergicPR:P61168-1 mDRD2/iso:1 MGI_ref:3628700; PMID:15489038
PR:P61168-2 mDRD2/iso:2 MGI_ref:3628700; PMID:15489038
GO:0042220 response to cocainePR:P61168-2 mDRD2/iso:2 MGI_ref:3655899; PMID:11943831
GO:0043278 response to morphinePR:P61168-2 mDRD2/iso:2 MGI_ref:3655899; PMID:11943831
GO:0051967 negative regulation of synaptic transmission, glutamatergicPR:P61168-2 mDRD2/iso:2 MGI_ref:3628700; PMID:15489038
GO:0060134 prepulse inhibitionPR:P61168-1 mDRD2/iso:1 MGI_ref:3611062; PMID:12476322
GO:0060160 negative regulation of dopamine receptor signaling pathwayPR:P61168-2 mDRD2/iso:2 MGI_ref:2181304; PMID:11089973

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/GoPR:P30728-2 mDRD3/iso:D3Short MGI_ref:71957; PMID:8449953
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0016020 membranePR:P61168-1 mDRD2/iso:1 MGI_ref:893272; PMID:7706278