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Protein Ontology report - interleukin-1 alpha
PR:000001135 - http://purl.obolibrary.org/obo/PR_000001135
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001135   
  PRO nameinterleukin-1 alpha 
  Synonyms
PRO-Short-label: EXACT:IL1A
Gene-based: RELATED:IL1F1
Other: EXACT:hematopoietin-1 | IL-1 alpha
  Definition"An interleukin-1 that is a translation product of the human IL1A gene or a 1:1 ortholog thereof. Critical mediator of the immune and inflammatory responses." [PRO:CNA, Wikipedia:Interleukin_1
  PRO Categorygene 
  ParentPR:000001091 interleukin-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification7                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000001135

interleukin-1 alpha

IL1A


"An interleukin-1 that is a translation product of the human IL1A gene or a 1:1 ortholog thereof. Critical mediator of the immune and inflammatory responses." [PRO:CNA, Wikipedia:Interleukin_1]


organism-gene



PR:P01582

interleukin-1 alpha (mouse)

mIL1A


"An interleukin-1 alpha that is encoded in the genome of mouse." [OMA:P01582, PRO:DNx]


organism-sequence



PR:P01582-1

interleukin-1 alpha isoform 1 (mouse)

mIL1A/iso:1


"An interleukin-1 alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036600

interleukin-1 alpha isoform 1 phosphorylated 1 (mouse)

mIL1A/iso:1/Phos:1


"An interleukin-1 alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:P01582-1, Ser-90, MOD:00046." [PMID:3126184, PRO:CNA]

Yes

organism-modification



PR:000045524

interleukin-1 alpha isoform 1 cleaved 1 (mouse)

mIL1A/iso:1/Clv:1


"An interleukin-1 alpha isoform 1 cleaved 1 in mouse. UniProtKB:P01582-1, 115-270." [PMID:23395675, PRO:HJD, UniProtKB:P01582]


organism-modification



PR:000045525

interleukin-1 alpha isoform 1 precursor (mouse)

mIl1a/iso:1/Full


"An interleukin-1 alpha isoform 1 (mouse) that has not been subjected to any proteolytic cleavage. UniProtKB:P01582-1, 1-270." [PMID:23395675, PRO:HJD, UniProtKB:P01582]


organism-gene



PR:P01583

interleukin-1 alpha (human)

hIL1A


"An interleukin-1 alpha that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01583]


organism-sequence



PR:P01583-1

interleukin-1 alpha isoform 1 (human)

hIL1A/iso:1


"An interleukin-1 alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036597

interleukin-1 alpha isoform 1 cleaved 1 (human)

hIL1A/iso:1/Clv:1


"An interleukin-1 alpha isoform 1 cleaved 1 in human. UniProtKB:P01583-1, 113-271." [PMID:3281727, PRO:CNA]

Yes

organism-modification



PR:000036598

interleukin-1 alpha isoform 1 myristoylated 1 (human)

hIL1A/iso:1/Myr:1


"An interleukin-1 alpha isoform 1 myristoylated 1 in human. UniProtKB:P01583-1, Lys-83, MOD:00087." [PMID:8346241, PRO:CNA]

Yes

organism-modification



PR:000036599

interleukin-1 alpha isoform 1 myristoylated 2 (human)

hIL1A/iso:1/Myr:2


"An interleukin-1 alpha isoform 1 myristoylated 2 in human. UniProtKB:P01583-1, Lys-82, MOD:00087." [PMID:8346241, PRO:CNA]

Yes

organism-gene



PR:P16598

interleukin-1 alpha (rat)

rIL1A


"An interleukin-1 alpha that is encoded in the genome of rat." [OMA:P16598, PRO:DNx]


sequence



PR:000001227

interleukin-1 alpha isoform 1

IL1A/iso:1


"An interleukin-1 alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01583-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P01582-1

interleukin-1 alpha isoform 1 (mouse)

mIL1A/iso:1


"An interleukin-1 alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036600

interleukin-1 alpha isoform 1 phosphorylated 1 (mouse)

mIL1A/iso:1/Phos:1


"An interleukin-1 alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:P01582-1, Ser-90, MOD:00046." [PMID:3126184, PRO:CNA]

Yes

organism-modification



PR:000045524

interleukin-1 alpha isoform 1 cleaved 1 (mouse)

mIL1A/iso:1/Clv:1


"An interleukin-1 alpha isoform 1 cleaved 1 in mouse. UniProtKB:P01582-1, 115-270." [PMID:23395675, PRO:HJD, UniProtKB:P01582]


organism-modification



PR:000045525

interleukin-1 alpha isoform 1 precursor (mouse)

mIl1a/iso:1/Full


"An interleukin-1 alpha isoform 1 (mouse) that has not been subjected to any proteolytic cleavage. UniProtKB:P01582-1, 1-270." [PMID:23395675, PRO:HJD, UniProtKB:P01582]


organism-sequence



PR:P01583-1

interleukin-1 alpha isoform 1 (human)

hIL1A/iso:1


"An interleukin-1 alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036597

interleukin-1 alpha isoform 1 cleaved 1 (human)

hIL1A/iso:1/Clv:1


"An interleukin-1 alpha isoform 1 cleaved 1 in human. UniProtKB:P01583-1, 113-271." [PMID:3281727, PRO:CNA]

Yes

organism-modification



PR:000036598

interleukin-1 alpha isoform 1 myristoylated 1 (human)

hIL1A/iso:1/Myr:1


"An interleukin-1 alpha isoform 1 myristoylated 1 in human. UniProtKB:P01583-1, Lys-83, MOD:00087." [PMID:8346241, PRO:CNA]

Yes

organism-modification



PR:000036599

interleukin-1 alpha isoform 1 myristoylated 2 (human)

hIL1A/iso:1/Myr:2


"An interleukin-1 alpha isoform 1 myristoylated 2 in human. UniProtKB:P01583-1, Lys-82, MOD:00087." [PMID:8346241, PRO:CNA]

Yes

modification



PR:000001259

interleukin-1 alpha isoform 1 myristoylated form

IL1A/iso:1/MyrRes+


"An interleukin-1 alpha isoform 1 that includes at least one myristoylated residue." [PRO:CNA]


modification



PR:000001268

interleukin-1 alpha isoform 1 myristoylated 1

IL1A/iso:1/Myr:1


"An interleukin-1 alpha isoform 1 myristoylated form with an N6-myristoyl Lys residue in the second Lys of the propeptide region. Example: UniProtKB:P01583-1, Lys-83, MOD:00087." [PMID:8346241]


organism-modification



PR:000036598

interleukin-1 alpha isoform 1 myristoylated 1 (human)

hIL1A/iso:1/Myr:1


"An interleukin-1 alpha isoform 1 myristoylated 1 in human. UniProtKB:P01583-1, Lys-83, MOD:00087." [PMID:8346241, PRO:CNA]

Yes

modification



PR:000001269

interleukin-1 alpha isoform 1 myristoylated 2

IL1A/iso:1/Myr:2


"An interleukin-1 alpha isoform 1 myristoylated form with an N6-myristoyl Lys residue in the first Lys of the propeptide region. Example: UniProtKB:P01583-1, Lys-82, MOD:00087." [PMID:8346241]


organism-modification



PR:000036599

interleukin-1 alpha isoform 1 myristoylated 2 (human)

hIL1A/iso:1/Myr:2


"An interleukin-1 alpha isoform 1 myristoylated 2 in human. UniProtKB:P01583-1, Lys-82, MOD:00087." [PMID:8346241, PRO:CNA]

Yes

modification



PR:000001260

interleukin-1 alpha isoform 1 phosphorylated form

IL1A/iso:1/PhosRes+


"An interleukin-1 alpha isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000001270

interleukin-1 alpha isoform 1 phosphorylated 1

IL1A/iso:1/Phos:1


"An interleukin-1 alpha isoform 1 phosphorylated form in which the phosphorylation occurs at a Ser residue within the propeptide region. Example: UniProtKB:P01582-1, Ser-90, MOD:00046." [PMID:3126184, PMID:3258335]


organism-modification



PR:000036600

interleukin-1 alpha isoform 1 phosphorylated 1 (mouse)

mIL1A/iso:1/Phos:1


"An interleukin-1 alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:P01582-1, Ser-90, MOD:00046." [PMID:3126184, PRO:CNA]

Yes

modification



PR:000001267

interleukin-1 alpha isoform 1 cleaved 1

IL1A/iso:1/Clv:1


"An interleukin-1 alpha isoform 1 that has had the propeptide removed. This is the mature peptide." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036597

interleukin-1 alpha isoform 1 cleaved 1 (human)

hIL1A/iso:1/Clv:1


"An interleukin-1 alpha isoform 1 cleaved 1 in human. UniProtKB:P01583-1, 113-271." [PMID:3281727, PRO:CNA]

Yes

organism-modification



PR:000045524

interleukin-1 alpha isoform 1 cleaved 1 (mouse)

mIL1A/iso:1/Clv:1


"An interleukin-1 alpha isoform 1 cleaved 1 in mouse. UniProtKB:P01582-1, 115-270." [PMID:23395675, PRO:HJD, UniProtKB:P01582]


modification



PR:000018344

interleukin-1 alpha proteolytic cleavage product

IL1A/ClvPrd


"An interleukin-1 alpha that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036597 hIL1A/iso:1/Clv:1
UniProtKB:P01583-1, 113-271
located_inGO:0005615 extracellular space PMID:3281727
PR:000036598 hIL1A/iso:1/Myr:1
UniProtKB:P01583-1, Lys-83, MOD:00087
located_inGO:0016020 membrane PMID:8346241
PR:000036599 hIL1A/iso:1/Myr:2
UniProtKB:P01583-1, Lys-82, MOD:00087
located_inGO:0016020 membrane PMID:8346241
PR:000036600 mIL1A/iso:1/Phos:1
UniProtKB:P01582-1, Ser-90, MOD:00046
located_inGO:0016020 membrane PMID:3126184