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Protein Ontology report - interleukin-1 receptor antagonist protein
PR:000001137 - http://purl.obolibrary.org/obo/PR_000001137
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001137   
  PRO nameinterleukin-1 receptor antagonist protein 
  Synonyms
PRO-Short-label: EXACT:IL1RN
Gene-based: RELATED:IL1F3 | IL1RA
Other: EXACT:anakinra | ICIL-1RA | IL-1ra | IL-1RN | IL1 inhibitor | IRAP
  Definition"A protein that is a translation product of the human IL1RN gene or a 1:1 ortholog thereof." [PRO:CNA] 
  CommentNote: The active form inhibits the activity of IL-1 by binding to its receptor. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 6                                        
         Modification3                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?
gene



PR:000001137 interleukin-1 receptor antagonist protein

IL1RN


organism-gene



PR:P18510 interleukin-1 receptor antagonist protein (human)

hIL1RN


organism-sequence



PR:P18510-1 interleukin-1 receptor antagonist protein isoform 1 (human)

hIL1RN/iso:1


organism-modification



PR:000036601 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human)

hIL1RN/iso:1/SigPep-

Yes

organism-sequence



PR:P18510-2 interleukin-1 receptor antagonist protein isoform 2 (human)

hIL1RN/iso:2

Yes

organism-sequence



PR:P18510-3 interleukin-1 receptor antagonist protein isoform 3 (human)

hIL1RN/iso:3

Yes

organism-sequence



PR:P18510-4 interleukin-1 receptor antagonist protein isoform 4 (human)

hIL1RN/iso:4

Yes

organism-gene



PR:P25085 interleukin-1 receptor antagonist protein (mouse)

mIL1RN


organism-sequence



PR:P25085-1 interleukin-1 receptor antagonist protein isoform 1 (mouse)

mIL1RN/iso:1


organism-sequence



PR:P25085-2 interleukin-1 receptor antagonist protein isoform 2 (mouse)

mIL1RN/iso:2

Yes

organism-gene



PR:P25086 interleukin-1 receptor antagonist protein (rat)

rIL1RN


sequence



PR:000001228 interleukin-1 receptor antagonist protein isoform 1

IL1RN/iso:1


organism-sequence



PR:P18510-1 interleukin-1 receptor antagonist protein isoform 1 (human)

hIL1RN/iso:1


organism-modification



PR:000036601 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human)

hIL1RN/iso:1/SigPep-

Yes

organism-sequence



PR:P25085-1 interleukin-1 receptor antagonist protein isoform 1 (mouse)

mIL1RN/iso:1


modification



PR:000001271 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form

IL1RN/iso:1/SigPep-


organism-modification



PR:000036601 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human)

hIL1RN/iso:1/SigPep-

Yes

sequence



PR:000001229 interleukin-1 receptor antagonist protein isoform 2

IL1RN/iso:2


organism-sequence



PR:P18510-2 interleukin-1 receptor antagonist protein isoform 2 (human)

hIL1RN/iso:2

Yes

organism-sequence



PR:P25085-2 interleukin-1 receptor antagonist protein isoform 2 (mouse)

mIL1RN/iso:2

Yes

sequence



PR:000001230 interleukin-1 receptor antagonist protein isoform 3

IL1RN/iso:3


organism-sequence



PR:P18510-3 interleukin-1 receptor antagonist protein isoform 3 (human)

hIL1RN/iso:3

Yes

sequence



PR:000001231 interleukin-1 receptor antagonist protein isoform 4

IL1RN/iso:4


organism-sequence



PR:P18510-4 interleukin-1 receptor antagonist protein isoform 4 (human)

hIL1RN/iso:4

Yes

modification



PR:000018347 interleukin-1 receptor antagonist protein, signal peptide removed form

IL1RN/SigPep-


modification



PR:000001271 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form

IL1RN/iso:1/SigPep-


organism-modification



PR:000036601 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human)

hIL1RN/iso:1/SigPep-

Yes

modification



PR:000025427 interleukin-1 receptor antagonist protein proteolytic cleavage product

IL1RN/ClvPrd


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036601 hIL1RN/iso:1/SigPep-
UniProtKB:P18510-1, 26-177
enablesGO:0045352 interleukin-1 type I receptor antagonist activity PMID:2139180
located_inGO:0005615 extracellular space PMID:2139180
PR:P18510-2 hIL1RN/iso:2 located_inGO:0005615 extracellular space PMID:16564702
GO:0005622 intracellular anatomical structure PMID:1827201
PR:P18510-3 hIL1RN/iso:3 located_inGO:0005622 intracellular anatomical structure PMID:7629520
PR:P18510-4 hIL1RN/iso:4 located_inGO:0005622 intracellular anatomical structure PMID:12671514
PR:P25085-2 mIL1RN/iso:2 located_inGO:0005615 extracellular space PMID:1524071