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RACE-PRO
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Documentation
Protein Ontology report - interleukin-17A
PR:000001138 -
http://purl.obolibrary.org/obo/PR_000001138
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000001138
PRO name
interleukin-17A
Synonyms
PRO-Short-label
:
EXACT:
IL17A
Gene-based
:
RELATED:
CTLA8 | IL17
Other
:
EXACT:
CTLA-8 | cytotoxic T-lymphocyte-associated antigen 8 | IL-17A
RELATED:
IL-17
Definition
"An interleukin-17 that is a translation product of the human IL17A gene or a 1:1 ortholog thereof. The active product is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases." [PRO:CNA,
Wikipedia:IL17A
]
PRO Category
gene
Parent
PR:000001092
interleukin-17
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
4
Sequence
0
Organism-Sequence
0
Modification
2
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF501045
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
gene
PR:000001138
interleukin-17A
IL17A
organism-gene
PR:Q16552
interleukin-17A (human)
hIL17A
organism-modification
PR:000036602
interleukin-17A, signal peptide removed form (human)
hIL17A/SigPep-
Yes
Yes
organism-gene
PR:Q5TKT0
interleukin 17_5 (zebrafish)
z-IL17A
organism-gene
PR:Q61453
interleukin-17A (rat)
rIL17A
organism-gene
PR:Q62386
interleukin-17A (mouse)
mIL17A
modification
PR:000018349
interleukin-17A, signal peptide removed form
IL17A/SigPep-
organism-modification
PR:000036602
interleukin-17A, signal peptide removed form (human)
hIL17A/SigPep-
Yes
Yes
modification
PR:000025428
interleukin-17A proteolytic cleavage product
IL17A/ClvPrd
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IL17A
forms found in complexes
IL17A
Component
Complexes
PR:000036602
hIL17A/SigPep-
PR:000044528
interleukin 17F/17A heterodimer (human)
PR:000044530
interleukin 17A homodimer (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036602
hIL17A/SigPep-
UniProtKB:Q16552, 24-155
enables
GO:0005125
cytokine activity
PMID:7499828
GO:0042803
protein homodimerization activity
PMID:15055556
located_in
GO:0005615
extracellular space
PMID:15340161
;
PMID:7499828