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Protein Ontology report - Toll-like receptor 3
PR:000001154 - http://purl.obolibrary.org/obo/PR_000001154
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001154   
  PRO nameToll-like receptor 3 
  Synonyms
PRO-Short-label: EXACT:TLR3
Other: EXACT:CD283
  Definition"A Toll-like receptor that is a translation product of the human TLR3 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001096 Toll-like receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1753
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000001154

Toll-like receptor 3

TLR3


"A Toll-like receptor that is a translation product of the human TLR3 gene or a 1:1 ortholog thereof." [PRO:CNA]


Yes
organism-gene



PR:O15455

Toll-like receptor 3 (human)

hTLR3


"A Toll-like receptor 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O15455]


organism-sequence



PR:O15455-1

Toll-like receptor 3 isoform h1 (human)

hTLR3/iso:h1


"A Toll-like receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15455-1." [PRO:DNx, UniProtKB:O15455]


organism-sequence



PR:O15455-2

Toll-like receptor 3 isoform h2 (human)

hTLR3/iso:h2


"A Toll-like receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15455-2." [PRO:DNx, UniProtKB:O15455]


organism-modification



PR:000037305

Toll-like receptor 3, signal peptide removed form (human)

hTLR3/SigPep-


"A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904." [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341]


Yes
organism-modification



PR:000060648

Toll-like receptor 3 sequence variant P554S, signal peptide removed form (human)

hTLR3/var:P554S/SigPep-


"A Toll-like receptor 3 (human) that has a Ser residue at the position equivalent to Pro-554 of the amino acid sequence represented by UniProtKB:O15455-1 and that has had the signal peptide removed. Example: UniProtKB:O15455-1, 24-904, Pro-554, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-5602428]


organism-modification



PR:000071103

Toll-like receptor 3 deaminated 1 (human)

hTLR3/Deam:1


"A Toll-like receptor 3 (human) that has been deaminated on the residue at the position equivalent to Asn-196 of the amino acid sequence represented by UniProtKB:O15455-1. Example: UniProtKB:O15455-1, Asn-196, MOD:00684." [IEDB_epitope:1977983, PRO:DNx]


organism-modification



PR:000075708

Toll-like receptor 3 deaminated 2 (human)

hTLR3/Deam:2


"A Toll-like receptor 3 (human) that has been deaminated on the residue at the position equivalent to Asn-70 of the amino acid sequence represented by UniProtKB:O15455-1. Example: UniProtKB:O15455-1, Asn-70, MOD:00684." [IEDB_epitope:494446, IEDB_epitope:494447, PRO:DNx]


organism-gene



PR:Q0PQ88

Toll-like receptor 3 (chicken)

chick-TLR3


"A Toll-like receptor 3 that is encoded in the genome of chicken." [PRO:CNA]


Yes
organism-modification



PR:000037796

Toll-like receptor 3, signal peptide removed form (chicken)

chick-TLR3/SigPep-


"A Toll-like receptor 3, signal peptide removed form in chicken. UniProtKB:Q0PQ88, 27-896." [PRO:CNA, PRO:DAN]


organism-gene



PR:Q99MB1

Toll-like receptor 3 (mouse)

mTLR3


"A Toll-like receptor 3 that is encoded in the genome of mouse." [OMA:Q99MB1, PRO:CNA]


organism-modification



PR:000037789

Toll-like receptor 3, signal peptide removed form (mouse)

mTLR3/SigPep-


"A Toll-like receptor 3, signal peptide removed form in mouse. UniProtKB:Q99MB1, 26-905." [ECO:0000250, PRO:CNA]


Yes
organism-gene



PR:Q9C9H6

receptor-like protein 11 (Arabidopsis thaliana)

At-TLR3


"A Toll-like receptor 3 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]


modification



PR:000018357

Toll-like receptor 3, signal peptide removed form

TLR3/SigPep-


"A Toll-like receptor 3 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000037305

Toll-like receptor 3, signal peptide removed form (human)

hTLR3/SigPep-


"A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904." [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341]


Yes
organism-modification



PR:000037789

Toll-like receptor 3, signal peptide removed form (mouse)

mTLR3/SigPep-


"A Toll-like receptor 3, signal peptide removed form in mouse. UniProtKB:Q99MB1, 26-905." [ECO:0000250, PRO:CNA]


Yes
organism-modification



PR:000037796

Toll-like receptor 3, signal peptide removed form (chicken)

chick-TLR3/SigPep-


"A Toll-like receptor 3, signal peptide removed form in chicken. UniProtKB:Q0PQ88, 27-896." [PRO:CNA, PRO:DAN]


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TLR3 forms found in complexes   

TLR3 Component
Complexes
PR:000001154 TLR3 PR:000037302 viral dsRNA:TLR3 complex
PR:000037305 hTLR3/SigPep- PR:000037303 viral dsRNA:TLR3 complex (human)
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)
PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037330 SARM:ticam1:activated TLR3 complex (human)
PR:000037332 rip3:ticam1:activated TLR3 complex (human)
PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037344 traf6:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037789 mTLR3/SigPep- PR:000037304 viral dsRNA:TLR3 complex (mouse)
PR:000037308 ticam1:viral dsRNA:TLR3 complex (mouse)
PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:Q0PQ88 chick-TLR3 PR:000037461 viral dsRNA:TLR3 complex (chicken)
PR:000037462 ticam1:viral dsRNA:TLR3 complex (chicken)