Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - D(2) dopamine receptor

PR:000001177 - http://purl.obolibrary.org/obo/PR_000001177

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000001177

PRO name

D(2) dopamine receptor

Synonyms

PRO-Short-label:	EXACT:	DRD2
Other:	EXACT:	dopamine D2 receptor

Definition

"A D(2)-like dopamine receptor that is a translation product of the human DRD2 gene or a 1:1 ortholog thereof." [PRO:WCB]

PRO Category

gene

Parent

PR:000001108 D(2)-like dopamine receptor

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	6
Sequence	2	Organism-Sequence	17
Modification	0	Organism-Modification	0

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Related Cross References
Db identifiers	IUPHARobj:215

Back to top

Protein Forms

Switch to Extended View

Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

gene

PR:000001177 D(2) dopamine receptor

DRD2

organism-gene

PR:P14416 D(2) dopamine receptor (human)

hDRD2

organism-sequence

PR:P14416-1 D(2) dopamine receptor isoform 1 (human)

hDRD2/iso:1

organism-sequence

PR:P14416-2 D(2) dopamine receptor isoform 2 (human)

hDRD2/iso:2

organism-sequence

PR:P14416-3 D(2) dopamine receptor isoform h3 (human)

hDRD2/iso:h3

organism-gene

PR:P61168 D(2) dopamine receptor (mouse)

mDRD2

organism-sequence

PR:P61168-1 D(2) dopamine receptor isoform 1 (mouse)

mDRD2/iso:1

Yes

organism-sequence

PR:P61168-2 D(2) dopamine receptor isoform 2 (mouse)

mDRD2/iso:2

Yes

organism-gene

PR:P61169 D(2) dopamine receptor (rat)

rDRD2

organism-sequence

PR:P61169-1 D(2) dopamine receptor isoform Long (rat)

rDRD2/iso:Long

organism-sequence

PR:P61169-2 D(2) dopamine receptor isoform Short (rat)

rDRD2/iso:Short

organism-gene

PR:Q6RYS9 dopamine receptor 3 (worm)

DRD2 (worm)

organism-sequence

PR:Q6RYS9-1 dopamine receptor 3 isoform b (worm)

DRD2/iso:b (worm)

organism-sequence

PR:Q6RYS9-2 dopamine receptor 3 isoform a (worm)

DRD2/iso:a (worm)

organism-sequence

PR:Q6RYS9-3 dopamine receptor 3 isoform c (worm)

DRD2/iso:c (worm)

organism-sequence

PR:Q6RYS9-4 dopamine receptor 3 isoform d (worm)

DRD2/iso:d (worm)

organism-gene

PR:Q8IS44 dopamine D2-like receptor (fruit fly)

fly-DRD2

organism-sequence

PR:Q8IS44-1 dopamine D2-like receptor isoform H (fruit fly)

fly-DRD2/iso:H

organism-sequence

PR:Q8IS44-2 dopamine D2-like receptor isoform J (fruit fly)

fly-DRD2/iso:J

organism-sequence

PR:Q8IS44-3 dopamine D2-like receptor isoform F (fruit fly)

fly-DRD2/iso:F

organism-sequence

PR:Q8IS44-4 dopamine D2-like receptor isoform B (fruit fly)

fly-DRD2/iso:B

organism-sequence

PR:Q8IS44-5 dopamine D2-like receptor isoform G (fruit fly)

fly-DRD2/iso:G

organism-sequence

PR:Q8IS44-6 dopamine D2-like receptor isoform I (fruit fly)

fly-DRD2/iso:I

organism-gene

PR:Q9GJU1 D(2) dopamine receptor (dog)

dog-DRD2

sequence

PR:000037412 D(2) dopamine receptor isoform 1

DRD2/iso:1

organism-sequence

PR:P14416-1 D(2) dopamine receptor isoform 1 (human)

hDRD2/iso:1

organism-sequence

PR:P61168-1 D(2) dopamine receptor isoform 1 (mouse)

mDRD2/iso:1

Yes

sequence

PR:000037413 D(2) dopamine receptor isoform 2

DRD2/iso:2

organism-sequence

PR:P14416-2 D(2) dopamine receptor isoform 2 (human)

hDRD2/iso:2

organism-sequence

PR:P61168-2 D(2) dopamine receptor isoform 2 (mouse)

mDRD2/iso:2

Yes

Back to top

Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:P61168-1 mDRD2/iso:1	acts_upstream_of_or_within	GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway	MGI_ref:893272; PMID:7706278
		GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway	MGI_ref:893272; PMID:7706278
		GO:0007212 dopamine receptor signaling pathway	MGI_ref:2181304; PMID:11089973
		GO:0007626 locomotory behavior	MGI_ref:1927281; PMID:11069937
		GO:0032228 regulation of synaptic transmission, GABAergic	MGI_ref:3628700; PMID:15489038
		GO:0060134 prepulse inhibition	MGI_ref:3611062; PMID:12476322
	enables	GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go	MGI_ref:893272; PMID:7706278
		GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go	MGI_ref:893272; PMID:7706278
		GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go	MGI_ref:893272; PMID:7706278
		GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go	MGI_ref:893272; PMID:7706278
	located_in	GO:0016020 membrane	MGI_ref:893272; PMID:7706278
PR:P61168-2 mDRD2/iso:2	acts_upstream_of_or_within	GO:0001975 response to amphetamine	MGI_ref:3611062; PMID:12476322
		GO:0014059 regulation of dopamine secretion	MGI_ref:3655899; PMID:11943831
		GO:0032228 regulation of synaptic transmission, GABAergic	MGI_ref:3628700; PMID:15489038
		GO:0042220 response to cocaine	MGI_ref:3655899; PMID:11943831
		GO:0043278 response to morphine	MGI_ref:3655899; PMID:11943831
		GO:0051967 negative regulation of synaptic transmission, glutamatergic	MGI_ref:3628700; PMID:15489038
		GO:0060160 negative regulation of dopamine receptor signaling pathway	MGI_ref:2181304; PMID:11089973
	enables	GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go	MGI_ref:892768; PMID:1991517
	enables	GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go	MGI_ref:892768; PMID:1991517