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Protein Ontology report - nuclear factor NF-kappa-B p105 subunit
PR:000001754 - http://purl.obolibrary.org/obo/PR_000001754
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001754   
  PRO namenuclear factor NF-kappa-B p105 subunit 
  Synonyms
PRO-Short-label: EXACT:NFKB1
Other: EXACT:DNA-binding factor KBF1 | EBP-1 | NF-kappa-B1 p84/NF-kappa-B1 p98 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  Definition"A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB1 gene or a 1:1 ortholog thereof. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis." [PMID:15485931, PRO:JAN] 
  PRO Categorygene 
  ParentPR:000001753 transcription factor NF-kappa-B subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence3                                                  Organism-Sequence 15                                        
         Modification5                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000001754

nuclear factor NF-kappa-B p105 subunit

NFKB1


"A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB1 gene or a 1:1 ortholog thereof. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis." [PMID:15485931, PRO:JAN]


organism-gene



PR:P19838

nuclear factor NF-kappa-B p105 subunit (human)

hNFKB1


"A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:P19838-1

nuclear factor NF-kappa-B p105 subunit isoform 1 (human)

hNFKB1/iso:1


"A nuclear factor NF-kappa-B p105 subunit isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P19838]


organism-sequence



PR:P19838-2

nuclear factor NF-kappa-B p105 subunit isoform 2 (human)

hNFKB1/iso:2


"A nuclear factor NF-kappa-B p105 subunit isoform 3 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P19838-3

nuclear factor NF-kappa-B p105 subunit isoform h3 (human)

hNFKB1/iso:h3


"A nuclear factor NF-kappa-B p105 subunit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19838-3." [PRO:DNx, UniProtKB:P19838]


organism-modification



PR:000035834

nuclear factor NF-kappa-B p50 subunit (human)

hNFKBp50


"A nuclear factor NF-kappa-B p50 subunit in human. Example: UniProtKB:P19838-1, 1-433." [PRO:DNx, UniProtKB:P19838]

Yes

Yes
organism-modification



PR:000045706

nuclear factor NF-kappa-B p105 subunit phosphorylated 1 (human)

hNFKB1/Phos:1


"A nuclear factor NF-kappa-B p105 subunit (human) that has been phosphorylated on the residue at the position equivalent to Ser-927 of the amino acid sequence represented by UniProtKB:P19838-1. Example: UniProtKB:P19838-1, Ser-927, MOD:00046." [iPTMnet:P19838, PMID:11297557, PMID:11976329]


organism-modification



PR:000048595

nuclear factor NF-kappa-B p105 subunit phosphorylated 2 (human)

hNFKB1/Phos:2


"A nuclear factor NF-kappa-B p105 subunit (human) that has been post-translationally modified to include phosphoserine at positions 927 and 932 of the amino acid sequence represented by UniProtKB:P19838. UniProtKB:P19838, Ser-927/Ser-932, MOD:00046." [PRO:DNx, Reactome:R-HSA-451611]


organism-modification



PR:000064699

nuclear factor NF-kappa-B p105 subunit phosphorylated and ubiquitinated 1 (human)

hNFKB1/PhosUbiq:1


"A nuclear factor NF-kappa-B p105 subunit (human) that has been phosphorylated on the residues at the positions equivalent to Ser-927 and Ser-932 of the amino acid sequence represented by UniProtKB:P19838-1 and that includes at least 3 ubiquitinated lysines. Example: UniProtKB:P19838-1, Ser-927/Ser-932, MOD:00046|MOD:01148(3+)." [PRO:DNx, Reactome:R-HSA-451619]


organism-modification



PR:000072853

nuclear factor NF-kappa-B p105 subunit deaminated 1 (human)

hNFKB1/Deam:1


"A nuclear factor NF-kappa-B p105 subunit (human) that has been deaminated on the residue at the position equivalent to Gln-45 of the amino acid sequence represented by UniProtKB:P19838-1. Example: UniProtKB:P19838-1, Gln-45, MOD:00685." [IEDB_epitope:929719, PRO:DNx]


organism-modification



PR:000075491

nuclear factor NF-kappa-B p105 subunit cysteinylated 1 (human)

hNFKB1/Cyst:1


"A nuclear factor NF-kappa-B p105 subunit (human) that has been cysteinylated on the residue at the position equivalent to Cys-666 of the amino acid sequence represented by UniProtKB:P19838-1. Example: UniProtKB:P19838-1, Cys-666, MOD:00765." [IEDB_epitope:1050024, PRO:DNx]


organism-modification



PR:000080523

nuclear factor NF-kappa-B p105 subunit deaminated 2 (human)

hNFKB1/Deam:2


"A nuclear factor NF-kappa-B p105 subunit (human) that has been deaminated on the residue at the position equivalent to Asn-456 of the amino acid sequence represented by UniProtKB:P19838-1. Example: UniProtKB:P19838-1, Asn-456, MOD:00684." [IEDB_epitope:1350766, PRO:DNx]


organism-modification



PR:000083954

nuclear factor NF-kappa-B p105 subunit deaminated 3 (human)

hNFKB1/Deam:3


"A nuclear factor NF-kappa-B p105 subunit (human) that has been deaminated on the residue at the position equivalent to Gln-878 of the amino acid sequence represented by UniProtKB:P19838-1. Example: UniProtKB:P19838-1, Gln-878, MOD:00685." [IEDB_epitope:1844356, PRO:DNx]


organism-gene



PR:P25799

nuclear factor NF-kappa-B p105 subunit (mouse)

mNFKB1


"A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of mouse." [OMA:P25799, PRO:DNx]


organism-sequence



PR:P25799-1

nuclear factor NF-kappa-B p105 subunit isoform 1 (mouse)

mNFKB1/iso:1


"A nuclear factor NF-kappa-B p105 subunit isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-modification



PR:000028540

nuclear factor NF-kappa-B p50 subunit (mouse)

mNFKBp50


"A nuclear factor NF-kappa-B p50 subunit in mouse. Example: UniProtKB:P25799-1, 1-431." [PMID:2203532, PRO:CNA]


Yes
organism-sequence



PR:P25799-2

nuclear factor NF-kappa-B p105 subunit isoform m2 (mouse)

mNFKB1/iso:m2


"A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-2." [PRO:DNx, UniProtKB:P25799]


organism-sequence



PR:P25799-3

nuclear factor NF-kappa-B p105 subunit isoform m3 (mouse)

mNFKB1/iso:m3


"A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-3." [PRO:DNx, UniProtKB:P25799]


organism-sequence



PR:P25799-4

nuclear factor NF-kappa-B p105 subunit isoform m4 (mouse)

mNFKB1/iso:m4


"A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-4." [PRO:DNx, UniProtKB:P25799]


organism-sequence



PR:P25799-5

nuclear factor NF-kappa-B p105 subunit isoform m5 (mouse)

mNFKB1/iso:m5


"A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-5." [PRO:DNx, UniProtKB:P25799]


organism-sequence



PR:P25799-6

nuclear factor NF-kappa-B p105 subunit isoform m6 (mouse)

mNFKB1/iso:m6


"A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-6." [PRO:DNx, UniProtKB:P25799]


organism-sequence



PR:P25799-7

nuclear factor NF-kappa-B p105 subunit isoform m7 (mouse)

mNFKB1/iso:m7


"A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-7." [PRO:DNx, UniProtKB:P25799]


organism-gene



PR:Q04861

nuclear factor NF-kappa-B p105 subunit (chicken)

chick-NFKB1


"A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of chicken." [OMA:Q04861, PRO:DNx]


organism-sequence



PR:Q04861-1

nuclear factor NF-kappa-B p105 subunit isoform 1 (chicken)

chick-NFKB1/iso:1


"A nuclear factor NF-kappa-B p105 subunit (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04861-1." [PRO:DNx, UniProtKB:Q04861]


organism-sequence



PR:Q04861-2

nuclear factor NF-kappa-B p105 subunit isoform 2 (chicken)

chick-NFKB1/iso:2


"A nuclear factor NF-kappa-B p105 subunit (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04861-2." [PRO:DNx, UniProtKB:Q04861]


organism-sequence



PR:Q04861-3

nuclear factor NF-kappa-B p105 subunit isoform 3 (chicken)

chick-NFKB1/iso:3


"A nuclear factor NF-kappa-B p105 subunit (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04861-3." [PRO:DNx, UniProtKB:Q04861]


organism-gene



PR:Q63369

nuclear factor NF-kappa-B p105 subunit (rat)

rNFKB1


"A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of rat." [OMA:Q63369, PRO:DNx]


organism-gene



PR:Q94527

nuclear factor NF-kappa-B p110 subunit (fruit fly)

fly-NFKB1


"A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of fruit fly." [OMA:Q94527, PRO:DNx]


organism-sequence



PR:Q94527-1

nuclear factor NF-kappa-B p110 subunit isoform Major (fruit fly)

fly-NFKB1/iso:Major


"A nuclear factor NF-kappa-B p110 subunit (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q94527-1." [PRO:DNx, UniProtKB:Q94527]


organism-sequence



PR:Q94527-2

nuclear factor NF-kappa-B p110 subunit isoform Maternal (fruit fly)

fly-NFKB1/iso:Maternal


"A nuclear factor NF-kappa-B p110 subunit (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q94527-2." [PRO:DNx, UniProtKB:Q94527]


sequence



PR:000001755

nuclear factor NF-kappa-B p105 subunit isoform 1

NFKB1/iso:1


"A nuclear factor NF-kappa-B p105 subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P25799-1

nuclear factor NF-kappa-B p105 subunit isoform 1 (mouse)

mNFKB1/iso:1


"A nuclear factor NF-kappa-B p105 subunit isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-modification



PR:000028540

nuclear factor NF-kappa-B p50 subunit (mouse)

mNFKBp50


"A nuclear factor NF-kappa-B p50 subunit in mouse. Example: UniProtKB:P25799-1, 1-431." [PMID:2203532, PRO:CNA]


Yes
modification



PR:000001757

nuclear factor NF-kappa-B p50 subunit

NFKBp50


"A nuclear factor NF-kappa-B p105 subunit isoform 1 that has been processed by proteolytic cleavage to remove the C-terminal domain of p105 downstream from the 23-residue glycine rich region (GRR). Example: UniProtKB:P19838-1, 1-433." [PMID:2203532, PMID:8628291, PRO:DAN, PRO:JAN]


organism-modification



PR:000028540

nuclear factor NF-kappa-B p50 subunit (mouse)

mNFKBp50


"A nuclear factor NF-kappa-B p50 subunit in mouse. Example: UniProtKB:P25799-1, 1-431." [PMID:2203532, PRO:CNA]


Yes
organism-modification



PR:000035834

nuclear factor NF-kappa-B p50 subunit (human)

hNFKBp50


"A nuclear factor NF-kappa-B p50 subunit in human. Example: UniProtKB:P19838-1, 1-433." [PRO:DNx, UniProtKB:P19838]

Yes

Yes
sequence



PR:000001758

nuclear factor NF-kappa-B p105 subunit isoform 2

NFKB1/iso:2


"A nuclear factor NF-kappa-B p105 subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19838-1 or a 1:1 ortholog thereof." [PMID:1992489]


organism-sequence



PR:P19838-1

nuclear factor NF-kappa-B p105 subunit isoform 1 (human)

hNFKB1/iso:1


"A nuclear factor NF-kappa-B p105 subunit isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P19838]


modification



PR:000001759

nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form

NFKB1/iso:2/PhosRes+


"A nuclear factor NF-kappa-B p105 subunit isoform 2 that includes at least one phosphorylated residue." [PRO:JAN]


modification



PR:000001760

nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 1

NFKB1/iso:2/Phos:1


"A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form in which the phosphorylation occurs by the action of GSK-3 beta which forms an in vivo complex with and specifically phosphorylates nuclear factor NF-kappa-B p105 subunit at two Ser residues in the C-terminal region contiguos to the Death domain. Phosphorylation by GSK-3 stabilizes the protein. Example: UniProtKB:P19838-1, Ser-903/Ser-907, MOD:00046." [PMID:12871932, PRO:JAN]


modification



PR:000001762

nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 2

NFKB1/iso:2/Phos:2


"A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form that has been pre-phosphorylated by GSK-3 beta (PR:000001760) followed by phosphorylation of the two Ser residues within the conserved motif DSGVETS in the PEST region. Phosphorylation occurs after the stimulation of cells with proinflammatory cytokines, such as tumor necrosis factor or interleukin-1. This phosphorylation results in accelerated nuclear factor NF-kappa-B p105 degradation. Example: UniProtKB:P19838-1, Ser-903/Ser-907/Ser-927/Ser-932, MOD:00046." [PMID:12482991, PMID:12871932]


sequence



PR:000001761

nuclear factor NF-kappa-B p105 subunit isoform 3

NFKB1/iso:3


"A nuclear factor NF-kappa-B p105 subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19838-2 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P19838-2

nuclear factor NF-kappa-B p105 subunit isoform 2 (human)

hNFKB1/iso:2


"A nuclear factor NF-kappa-B p105 subunit isoform 3 that is encoded in the genome of human." [PRO:JAN]


modification



PR:000018519

nuclear factor NF-kappa-B p105 subunit proteolytic cleavage product

NFKB1/ClvPrd


"A nuclear factor NF-kappa-B p105 subunit that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000001757

nuclear factor NF-kappa-B p50 subunit

NFKBp50


"A nuclear factor NF-kappa-B p105 subunit isoform 1 that has been processed by proteolytic cleavage to remove the C-terminal domain of p105 downstream from the 23-residue glycine rich region (GRR). Example: UniProtKB:P19838-1, 1-433." [PMID:2203532, PMID:8628291, PRO:DAN, PRO:JAN]


organism-modification



PR:000028540

nuclear factor NF-kappa-B p50 subunit (mouse)

mNFKBp50


"A nuclear factor NF-kappa-B p50 subunit in mouse. Example: UniProtKB:P25799-1, 1-431." [PMID:2203532, PRO:CNA]


Yes
organism-modification



PR:000035834

nuclear factor NF-kappa-B p50 subunit (human)

hNFKBp50


"A nuclear factor NF-kappa-B p50 subunit in human. Example: UniProtKB:P19838-1, 1-433." [PRO:DNx, UniProtKB:P19838]

Yes

Yes
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NFKB1 forms found in complexes   

NFKB1 Component
Complexes
PR:000028540 mNFKBp50 PR:000028542 NF-kappaB p50/p65 complex (mouse)
PR:000035834 hNFKBp50 PR:000035835 NF-kappaB p50/p65 complex (human)
PR:P19838 hNFKB1 PR:000028444 NFKB p105:TPL2:ABIN2 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035834 hNFKBp50
Example: UniProtKB:P19838-1, 1-433
acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894