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Protein Ontology report - DNA-binding protein Ikaros
PR:000001811 - http://purl.obolibrary.org/obo/PR_000001811
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001811   
  PRO nameDNA-binding protein Ikaros 
  Synonyms
PRO-Short-label: EXACT:IKZF1
Gene-based: RELATED:IK1 | IKAROS | LYF1 | Zfpn1a1 | ZNFN1A1
Other: EXACT:Ikaros family zinc finger protein 1 | lymphoid transcription factor LyF-1
  Definition"An Ikaros-like zinc finger transcription factor that is a translation product of the human IKZF1 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000002986 Ikaros-like zinc finger transcription factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence6                                                  Organism-Sequence 15                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000001811

DNA-binding protein Ikaros

IKZF1


"An Ikaros-like zinc finger transcription factor that is a translation product of the human IKZF1 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:O42410

DNA-binding protein Ikaros (chicken)

chick-IKZF1


"A DNA-binding protein Ikaros that is encoded in the genome of chicken." [PRO:WCB]


organism-sequence



PR:O42410-1

DNA-binding protein Ikaros isoform 1 (chicken)

chick-IKZF1/iso:1


"A DNA-binding protein Ikaros (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O42410-1." [PRO:DNx, UniProtKB:O42410]


organism-gene



PR:Q03267

DNA-binding protein Ikaros (mouse)

mIKZF1


"A DNA-binding protein Ikaros that is encoded in the genome of mouse." [OMA:Q03267, PRO:DNx]


organism-sequence



PR:Q03267-1

DNA-binding protein Ikaros isoform VI (mouse)

mIKZF1/iso:VI


"A DNA-binding protein Ikaros isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-sequence



PR:Q03267-2

DNA-binding protein Ikaros isoform I (mouse)

mIKZF1/iso:I


"A DNA-binding protein Ikaros isoform 2 that is encoded in the genome of mouse." [PRO:HJD]


organism-sequence



PR:Q03267-3

DNA-binding protein Ikaros isoform II (mouse)

mIKZF1/iso:II


"A DNA-binding protein Ikaros isoform 3 that is encoded in the genome of mouse." [PRO:HJD]


organism-sequence



PR:Q03267-4

DNA-binding protein Ikaros isoform III (mouse)

mIKZF1/iso:III


"A DNA-binding protein Ikaros isoform 4 that is encoded in the genome of mouse." [PRO:HJD]


organism-sequence



PR:Q03267-5

DNA-binding protein Ikaros isoform IV (mouse)

mIKZF1/iso:IV


"A DNA-binding protein Ikaros isoform 5 that is encoded in the genome of mouse." [PRO:HJD]


organism-sequence



PR:Q03267-6

DNA-binding protein Ikaros isoform V (mouse)

mIKZF1/iso:V


"A DNA-binding protein Ikaros isoform 6 that is encoded in the genome of mouse." [PRO:HJD]


organism-gene



PR:Q13422

DNA-binding protein Ikaros (human)

hIKZF1


"A DNA-binding protein Ikaros that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q13422]


organism-sequence



PR:Q13422-1

DNA-binding protein Ikaros isoform Ik1 (human)

hIKZF1/iso:Ik1


"A DNA-binding protein Ikaros isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q13422-2

DNA-binding protein Ikaros isoform Ik2 (human)

hIKZF1/iso:Ik2


"A DNA-binding protein Ikaros isoform 6 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q13422-3

DNA-binding protein Ikaros isoform hIk3 (human)

hIKZF1/iso:hIk3


"A DNA-binding protein Ikaros (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13422-3." [PRO:DNx, UniProtKB:Q13422]


organism-sequence



PR:Q13422-4

DNA-binding protein Ikaros isoform hIk4 (human)

hIKZF1/iso:hIk4


"A DNA-binding protein Ikaros (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13422-4." [PRO:DNx, UniProtKB:Q13422]


organism-sequence



PR:Q13422-5

DNA-binding protein Ikaros isoform Ik5 (human)

hIKZF1/iso:Ik5


"A DNA-binding protein Ikaros isoform 4 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q13422-6

DNA-binding protein Ikaros isoform Ik6 (human)

hIKZF1/iso:Ik6


"A DNA-binding protein Ikaros isoform 2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q13422-7

DNA-binding protein Ikaros isoform hIk7 (human)

hIKZF1/iso:hIk7


"A DNA-binding protein Ikaros (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13422-7." [PRO:DNx, UniProtKB:Q13422]


organism-sequence



PR:Q13422-8

DNA-binding protein Ikaros isoform Ikx (human)

hIKZF1/iso:Ikx


"A DNA-binding protein Ikaros (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13422-8." [PRO:DNx, UniProtKB:Q13422]


organism-modification



PR:000069199

DNA-binding protein Ikaros methylated 1 (human)

hIKZF1/Me:1


"A DNA-binding protein Ikaros (human) that has been methylated on the residue at the position equivalent to Cys-254 of the amino acid sequence represented by UniProtKB:Q13422-1. Example: UniProtKB:Q13422-1, Cys-254, MOD:00660." [IEDB_epitope:1005407, PRO:DNx]


organism-modification



PR:000070058

DNA-binding protein Ikaros citrullinated 1 (human)

hIKZF1/Cit:1


"A DNA-binding protein Ikaros (human) that has been citrullinated on the residue at the position equivalent to Arg-423 of the amino acid sequence represented by UniProtKB:Q13422-1. Example: UniProtKB:Q13422-1, Arg-423, MOD:00219." [IEDB_epitope:911961, PRO:DNx]


organism-modification



PR:000070450

DNA-binding protein Ikaros deaminated 1 (human)

hIKZF1/Deam:1


"A DNA-binding protein Ikaros (human) that has been deaminated on the residue at the position equivalent to Asn-424 of the amino acid sequence represented by UniProtKB:Q13422-1. Example: UniProtKB:Q13422-1, Asn-424, MOD:00684." [IEDB_epitope:836769, PRO:DNx]


sequence



PR:000002150

DNA-binding protein Ikaros isoform 1

IKZF1/iso:1


"A DNA-binding protein Ikaros that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03267-1 or a 1:1 ortholog thereof." [PRO:HJD]


organism-sequence



PR:Q03267-1

DNA-binding protein Ikaros isoform VI (mouse)

mIKZF1/iso:VI


"A DNA-binding protein Ikaros isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-sequence



PR:Q13422-1

DNA-binding protein Ikaros isoform Ik1 (human)

hIKZF1/iso:Ik1


"A DNA-binding protein Ikaros isoform 1 that is encoded in the genome of human." [PRO:HJD]


modification



PR:000018259

DNA-binding protein Ikaros isoform 1 phosphorylated form

IKZF1/iso:1/PhosRes+


"A DNA-binding protein Ikaros isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000018260

DNA-binding protein Ikaros isoform 1 phosphorylated 1

IKZF1/iso:1/Phos:1


"A DNA-binding protein Ikaros isoform 1 phosphorylated form in which the phosphorylation occurs within the serine/threonine-rich conserved region (p1)." [PMID:15024069]


sequence



PR:000002151

DNA-binding protein Ikaros isoform 2

IKZF1/iso:2


"A DNA-binding protein Ikaros that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03267-2 or a 1:1 ortholog thereof." [PMID:18623087, PMID:8895580, PRO:DAN, PRO:HJD]


organism-sequence



PR:Q03267-2

DNA-binding protein Ikaros isoform I (mouse)

mIKZF1/iso:I


"A DNA-binding protein Ikaros isoform 2 that is encoded in the genome of mouse." [PRO:HJD]


organism-sequence



PR:Q13422-6

DNA-binding protein Ikaros isoform Ik6 (human)

hIKZF1/iso:Ik6


"A DNA-binding protein Ikaros isoform 2 that is encoded in the genome of human." [PRO:HJD]


sequence



PR:000002152

DNA-binding protein Ikaros isoform 3

IKZF1/iso:3


"A DNA-binding protein Ikaros that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03267-3 or a 1:1 ortholog thereof." [PRO:HJD]


organism-sequence



PR:Q03267-3

DNA-binding protein Ikaros isoform II (mouse)

mIKZF1/iso:II


"A DNA-binding protein Ikaros isoform 3 that is encoded in the genome of mouse." [PRO:HJD]


sequence



PR:000002153

DNA-binding protein Ikaros isoform 4

IKZF1/iso:4


"A DNA-binding protein Ikaros that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03267-4 or a 1:1 ortholog thereof." [PMID:11781232, PRO:DAN, PRO:HJD]


organism-sequence



PR:Q03267-4

DNA-binding protein Ikaros isoform III (mouse)

mIKZF1/iso:III


"A DNA-binding protein Ikaros isoform 4 that is encoded in the genome of mouse." [PRO:HJD]


organism-sequence



PR:Q13422-5

DNA-binding protein Ikaros isoform Ik5 (human)

hIKZF1/iso:Ik5


"A DNA-binding protein Ikaros isoform 4 that is encoded in the genome of human." [PRO:HJD]


sequence



PR:000002154

DNA-binding protein Ikaros isoform 5

IKZF1/iso:5


"A DNA-binding protein Ikaros that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03267-5 or a 1:1 ortholog thereof." [PRO:HJD]


organism-sequence



PR:Q03267-5

DNA-binding protein Ikaros isoform IV (mouse)

mIKZF1/iso:IV


"A DNA-binding protein Ikaros isoform 5 that is encoded in the genome of mouse." [PRO:HJD]


sequence



PR:000002155

DNA-binding protein Ikaros isoform 6

IKZF1/iso:6


"A DNA-binding protein Ikaros that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03267-6 or a 1:1 ortholog thereof." [PMID:1439790, PMID:8964602, PRO:HJD]


organism-sequence



PR:Q03267-6

DNA-binding protein Ikaros isoform V (mouse)

mIKZF1/iso:V


"A DNA-binding protein Ikaros isoform 6 that is encoded in the genome of mouse." [PRO:HJD]


organism-sequence



PR:Q13422-2

DNA-binding protein Ikaros isoform Ik2 (human)

hIKZF1/iso:Ik2


"A DNA-binding protein Ikaros isoform 6 that is encoded in the genome of human." [PRO:HJD]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q03267-1 mIKZF1/iso:VI acts_upstream_of_or_withinGO:0000122 negative regulation of transcription by RNA polymerase II PMID:12617992
GO:0001779 natural killer cell differentiation PMID:7923373
GO:0051138 positive regulation of NK T cell differentiation MGI_ref:1340364; PMID:10366784
GO:0060041 retina development in camera-type eye MGI_ref:3831471; PMID:18940586
enablesGO:0046982 protein heterodimerization activity with PR:P81183-1|PR:P81183-2 MGI_ref:1333610; PMID:10218586
GO:0046982 protein heterodimerization activity with PR:Q8C208-1 MGI_ref:1333610; PMID:10218586
located_inGO:0005634 nucleus MGI_ref:2652944; PMID:12617992