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Protein Ontology report - CD14 molecule

PR:000001889 - http://purl.obolibrary.org/obo/PR_000001889

Protein Forms

Complex

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000001889

PRO name

CD14 molecule

Synonyms

PRO-Short-label:	EXACT:	CD14
Other:	EXACT:	monocyte differentiation antigen CD14 \| myeloid cell-specific leucine-rich glycoprotein

Definition

"A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [PRO:WCB]

Comment

Requested by=CL.

PRO Category

gene

Parent

PR:000000001 protein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	4
Sequence	0	Organism-Sequence	0
Modification	7	Organism-Modification	19

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	PIRSF:PIRSF002017

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

gene

PR:000001889 CD14 molecule

CD14

Yes

organism-gene

PR:B0BL87 CD14 molecule (chicken)

chick-CD14

Yes

organism-gene

PR:P08571 monocyte differentiation antigen CD14 (human)

hCD14

Yes

organism-modification

PR:000036615 CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble

Yes

organism-modification

PR:000036945 CD14 molecule cleaved and soluble form (human)

hCD14/ClvPrd/soluble

organism-modification

PR:000035703 CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble

organism-modification

PR:000036615 CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble

organism-modification

PR:000037480 CD14 molecule cleaved 2 (human)

hCD14/Clv:2

Yes

organism-modification

PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)

hCD14/Clv:2/anchored

Yes

organism-modification

PR:000035703 CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble

Yes

organism-modification

PR:000050392 presepsin (human)

hPSEP

organism-modification

PR:000054476 monocyte differentiation antigen CD14 N-glycosylated 1 (human)

hCD14/NGlyco:1

organism-modification

PR:000054477 monocyte differentiation antigen CD14 O-glycosylated 1 (human)

hCD14/OGlyco:1

organism-modification

PR:000054478 monocyte differentiation antigen CD14 O-glycosylated 2 (human)

hCD14/OGlyco:2

organism-modification

PR:000054479 monocyte differentiation antigen CD14 O-glycosylated 3 (human)

hCD14/OGlyco:3

organism-modification

PR:000054480 monocyte differentiation antigen CD14 O-glycosylated 4 (human)

hCD14/OGlyco:4

organism-modification

PR:000054481 monocyte differentiation antigen CD14 O-glycosylated 5 (human)

hCD14/OGlyco:5

organism-modification

PR:000065690 monocyte differentiation antigen CD14 cysteinylated 1 (human)

hCD14/Cyst:1

organism-modification

PR:000079106 monocyte differentiation antigen CD14 deaminated 1 (human)

hCD14/Deam:1

organism-gene

PR:P10810 monocyte differentiation antigen CD14 (mouse)

mCD14

Yes

organism-modification

PR:000036850 CD14 molecule cleaved and soluble form (mouse)

mCD14/ClvPrd/soluble

Yes

organism-modification

PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble

organism-modification

PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble

organism-modification

PR:000036946 CD14 molecule cleaved 2 (mouse)

mCD14/Clv:2

organism-modification

PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble

organism-modification

PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse)

mCD14/Clv:2/anchored

organism-modification

PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble

Yes

organism-gene

PR:Q63691 monocyte differentiation antigen CD14 (rat)

rCD14

modification

PR:000018574 CD14 molecule, signal peptide removed form

CD14/SigPep-

modification

PR:000002146 CD14 molecule cleaved 1 soluble form

CD14/Clv:1/soluble

organism-modification

PR:000036615 CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble

Yes

organism-modification

PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble

Yes

modification

PR:000002148 CD14 molecule cleaved and GPI-anchored form

CD14/ClvPrd/anchored

modification

PR:000036848 CD14 molecule cleaved 2

CD14/Clv:2

Yes

modification

PR:000002147 CD14 molecule cleaved 2 soluble form

CD14/Clv:2/soluble

Yes

organism-modification

PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble

organism-modification

PR:000035703 CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble

Yes

modification

PR:000002149 CD14 molecule cleaved 2 GPI-anchored form

CD14/Clv:2/anchored

Yes

organism-modification

PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)

hCD14/Clv:2/anchored

Yes

organism-modification

PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse)

mCD14/Clv:2/anchored

Yes

organism-modification

PR:000036946 CD14 molecule cleaved 2 (mouse)

mCD14/Clv:2

organism-modification

PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble

organism-modification

PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse)

mCD14/Clv:2/anchored

organism-modification

PR:000037480 CD14 molecule cleaved 2 (human)

hCD14/Clv:2

Yes

organism-modification

PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)

hCD14/Clv:2/anchored

Yes

organism-modification

PR:000035703 CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble

Yes

modification

PR:000036849 CD14 molecule cleaved and soluble form

CD14/ClvPrd/soluble

Yes

modification

PR:000002146 CD14 molecule cleaved 1 soluble form

CD14/Clv:1/soluble

organism-modification

PR:000036615 CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble

Yes

organism-modification

PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble

Yes

modification

PR:000002147 CD14 molecule cleaved 2 soluble form

CD14/Clv:2/soluble

organism-modification

PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble

organism-modification

PR:000035703 CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble

Yes

organism-modification

PR:000036850 CD14 molecule cleaved and soluble form (mouse)

mCD14/ClvPrd/soluble

Yes

organism-modification

PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble

organism-modification

PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble

organism-modification

PR:000036945 CD14 molecule cleaved and soluble form (human)

hCD14/ClvPrd/soluble

organism-modification

PR:000035703 CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble

organism-modification

PR:000036615 CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble

organism-modification

PR:000050392 presepsin (human)

hPSEP

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CD14 forms found in complexes

CD14 Component	Complexes
PR:000001889 CD14	PR:000037465 LPS:CD14 complex
PR:000002147 CD14/Clv:2/soluble	PR:000025494 LPS:secreted CD14 alpha
	PR:000025496 lipopolysaccharide receptor complex 2
	PR:000025498 lipopolysaccharide receptor complex 4
PR:000002149 CD14/Clv:2/anchored	PR:000025493 LPS:GPI-anchored CD14 complex
	PR:000025495 lipopolysaccharide receptor complex 1
	PR:000025497 lipopolysaccharide receptor complex 3
PR:000035702 hCD14/Clv:2/anchored	PR:000025773 lipopolysaccharide receptor complex 3 (human)
	PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
	PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
	PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble	PR:000037463 LPS:secreted CD14 alpha (human)
PR:000035703 hCD14/Clv:2/soluble	PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000036849 CD14/ClvPrd/soluble	PR:000029989 LPS:secreted CD14 complex
PR:000036850 mCD14/ClvPrd/soluble	PR:000037467 LPS:secreted CD14 complex (mouse)
PR:000037470 mCD14/Clv:2/anchored	PR:000037468 LPS:GPI-anchored CD14 complex (mouse)
PR:000037470 mCD14/Clv:2/anchored	PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000037480 hCD14/Clv:2	PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
	PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
	PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
	PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:B0BL87 chick-CD14	PR:000037466 LPS:transmembrane CD14 complex (chicken)

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Functional Annotation (GO-centric view)

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Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0032147 activation of protein kinase activity	PR:000036848 CD14/Clv:2	MGI_ref:3836081; PMID:18854309
GO:0034142 toll-like receptor 4 signaling pathway	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_6894
GO:0034142 toll-like receptor 4 signaling pathway	PR:000035703 hCD14/Clv:2/soluble	Reactome:REACT_6894
Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0001530 lipopolysaccharide binding	PR:000035703 hCD14/Clv:2/soluble	PMID:9464818
Cellular Location GO Term	Protein Forms & Complexes	Evidence
CL:0000127 astrocyte	PR:P10810 mCD14	PMID:24659539
NOT CL:0000127 astrocyte	PR:P08571 hCD14	PMID:24659539
CL:0000129 microglial cell	PR:000035703 hCD14/Clv:2/soluble	PMID:24659539
CL:0000129 microglial cell	PR:000037469 mCD14/Clv:1/soluble	PMID:24659539
GO:0005576 extracellular region	PR:000035703 hCD14/Clv:2/soluble	PMID:2779588; PMID:9665271
GO:0005576 extracellular region	PR:000036615 hCD14/Clv:1/soluble	PMID:7519994
GO:0005737 cytoplasm	PR:000036848 CD14/Clv:2	MGI_ref:3836081; PMID:18854309
GO:0005886 plasma membrane	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
PR:B0BL87 chick-CD14	PMID:18761368
GO:0009986 cell surface	PR:B0BL87 chick-CD14	PMID:18761368
GO:0016020 membrane	PR:000036848 CD14/Clv:2	MGI_ref:3836081; PMID:18854309