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Protein Ontology report - CD14 molecule
PR:000001889 - http://purl.obolibrary.org/obo/PR_000001889
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001889   
  PRO nameCD14 molecule 
  Synonyms
PRO-Short-label: EXACT:CD14
Other: EXACT:monocyte differentiation antigen CD14 | myeloid cell-specific leucine-rich glycoprotein
  Definition"A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification7                                                  Organism-Modification 19                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002017
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000001889

CD14 molecule

CD14


"A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [PRO:WCB]


Yes
organism-gene



PR:B0BL87

CD14 molecule (chicken)

chick-CD14


"A CD14 molecule that is encoded in the genome of chicken." [PRO:CNA]

Yes

Yes
organism-gene



PR:P08571

monocyte differentiation antigen CD14 (human)

hCD14


"A CD14 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08571]

Yes

organism-modification



PR:000036615

CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]

Yes

organism-modification



PR:000036945

CD14 molecule cleaved and soluble form (human)

hCD14/ClvPrd/soluble


"A CD14 molecule cleaved and soluble form in human." [PRO:DAN]


organism-modification



PR:000035703

CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]


organism-modification



PR:000036615

CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]


organism-modification



PR:000037480

CD14 molecule cleaved 2 (human)

hCD14/Clv:2


"A CD14 molecule cleaved 2 in human. This represents both the GPI-anchored and soluble forms. UniProtKB:P08571, 20-345." [PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000035702

CD14 molecule cleaved 2 GPI-anchored form (human)

hCD14/Clv:2/anchored


"A CD14 molecule cleaved 2 GPI-anchored form in human. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]

Yes

Yes
organism-modification



PR:000035703

CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]

Yes

Yes
organism-modification



PR:000050392

presepsin (human)

hPSEP


"A CD14 molecule, signal peptide removed form that has been cleaved by plasma proteases to yield a soluble 13kD N-terminal fragment in human." [PMID:16258819, PMID:21740312, PMID:25215141, PRO:DAN]


organism-modification



PR:000054476

monocyte differentiation antigen CD14 N-glycosylated 1 (human)

hCD14/NGlyco:1


"A monocyte differentiation antigen CD14 (human) that has been N-glycosylated at the residue equivalent to Asn-151 of the amino acid sequence represented by UniProtKB:P08571, in which the glycan composition is represented by GlyTouCan:G59626AS. UniProtKB:P08571, Asn-151, MOD:00160~GNO:G59626AS." [GlyGen:P08571, PMID:29671580, PRO:DNx]


organism-modification



PR:000054477

monocyte differentiation antigen CD14 O-glycosylated 1 (human)

hCD14/OGlyco:1


"A monocyte differentiation antigen CD14 (human) that has been O-glycosylated at the residue equivalent to Ser-362 of the amino acid sequence represented by UniProtKB:P08571, in which the glycan composition is represented by GlyTouCan:G43417UB. UniProtKB:P08571, Ser-362, MOD:00002~GNO:G43417UB." [GlyGen:P08571, PMID:30459171, PRO:DNx]


organism-modification



PR:000054478

monocyte differentiation antigen CD14 O-glycosylated 2 (human)

hCD14/OGlyco:2


"A monocyte differentiation antigen CD14 (human) that has been O-glycosylated at the residue equivalent to Thr-336 of the amino acid sequence represented by UniProtKB:P08571, in which the glycan composition is represented by GlyTouCan:G27391WQ. UniProtKB:P08571, Thr-336, MOD:00005~GNO:G27391WQ." [GlyGen:P08571, PMID:30459171, PRO:DNx]


organism-modification



PR:000054479

monocyte differentiation antigen CD14 O-glycosylated 3 (human)

hCD14/OGlyco:3


"A monocyte differentiation antigen CD14 (human) that has been O-glycosylated at the residue equivalent to Thr-336 of the amino acid sequence represented by UniProtKB:P08571, in which the glycan composition is represented by GlyTouCan:G29068FM. UniProtKB:P08571, Thr-336, MOD:00005~GNO:G29068FM." [GlyGen:P08571, PMID:30459171, PRO:DNx]


organism-modification



PR:000054480

monocyte differentiation antigen CD14 O-glycosylated 4 (human)

hCD14/OGlyco:4


"A monocyte differentiation antigen CD14 (human) that has been O-glycosylated at the residue equivalent to Thr-336 of the amino acid sequence represented by UniProtKB:P08571, in which the glycan composition is represented by GlyTouCan:G43417UB. UniProtKB:P08571, Thr-336, MOD:00005~GNO:G43417UB." [GlyGen:P08571, PMID:30459171, PRO:DNx]


organism-modification



PR:000054481

monocyte differentiation antigen CD14 O-glycosylated 5 (human)

hCD14/OGlyco:5


"A monocyte differentiation antigen CD14 (human) that has been O-glycosylated at the residue equivalent to Thr-364 of the amino acid sequence represented by UniProtKB:P08571, in which the glycan composition is represented by GlyTouCan:G43417UB. UniProtKB:P08571, Thr-364, MOD:00005~GNO:G43417UB." [GlyGen:P08571, PMID:30459171, PRO:DNx]


organism-modification



PR:000065690

monocyte differentiation antigen CD14 cysteinylated 1 (human)

hCD14/Cyst:1


"A monocyte differentiation antigen CD14 (human) that has been cysteinylated on the residue at the position equivalent to Cys-241 of the amino acid sequence represented by UniProtKB:P08571. UniProtKB:P08571, Cys-241, MOD:00765." [IEDB_epitope:881074, PRO:DNx]


organism-modification



PR:000079106

monocyte differentiation antigen CD14 deaminated 1 (human)

hCD14/Deam:1


"A monocyte differentiation antigen CD14 (human) that has been deaminated on the residue at the position equivalent to Asn-151 of the amino acid sequence represented by UniProtKB:P08571. UniProtKB:P08571, Asn-151, MOD:00684." [IEDB_epitope:1333053, PRO:DNx]


organism-gene



PR:P10810

monocyte differentiation antigen CD14 (mouse)

mCD14


"A CD14 molecule that is encoded in the genome of mouse." [OMA:P10810, PRO:WCB]

Yes

organism-modification



PR:000036850

CD14 molecule cleaved and soluble form (mouse)

mCD14/ClvPrd/soluble


"A CD14 molecule cleaved and soluble form in mouse." [PRO:DAN]


Yes
organism-modification



PR:000029986

CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]


organism-modification



PR:000037469

CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]


organism-modification



PR:000036946

CD14 molecule cleaved 2 (mouse)

mCD14/Clv:2


"A CD14 molecule cleaved 2 in mouse. This represents both the GPI-anchored and soluble forms. UniProtKB:P10810, 16-336." [PRO:DAN]


organism-modification



PR:000029986

CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]


organism-modification



PR:000037470

CD14 molecule cleaved 2 GPI-anchored form (mouse)

mCD14/Clv:2/anchored


"A CD14 molecule cleaved 2 GPI-anchored form in mouse. UniProtKB:P10810, 16-336, Asn-336, MOD:00167." [PMID:10601848, PMID:18606699, PRO:CNA]


organism-modification



PR:000037469

CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]

Yes

organism-gene



PR:Q63691

monocyte differentiation antigen CD14 (rat)

rCD14


"A CD14 molecule that is encoded in the genome of rat." [OMA:Q63691, PRO:DNx]


modification



PR:000018574

CD14 molecule, signal peptide removed form

CD14/SigPep-


"A CD14 molecule that has had the signal peptide removed." [PRO:DNx]


modification



PR:000002146

CD14 molecule cleaved 1 soluble form

CD14/Clv:1/soluble


"A CD14 molecule, signal peptide removed form that lacks the GPI-anchor and has been processed by proteolytic cleavage to yield the N-terminal domain with extra C-terminal residues as compared to cleaved 2 form." [PMID:7519994]


organism-modification



PR:000036615

CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]

Yes

organism-modification



PR:000037469

CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]

Yes

modification



PR:000002148

CD14 molecule cleaved and GPI-anchored form

CD14/ClvPrd/anchored


"A CD14 molecule, signal peptide removed form that has been processed by proteolytic cleavage to yield the N-terminal domain that has been post-translationally modified to include a GPI-anchor." [PRO:CNA, PRO:DAN]


modification



PR:000036848

CD14 molecule cleaved 2

CD14/Clv:2


"A CD14 molecule, signal peptide removed form that lacks the propeptide. Example: UniProtKB:P08571, 20-345." [PRO:DAN]

Yes

modification



PR:000002147

CD14 molecule cleaved 2 soluble form

CD14/Clv:2/soluble


"A CD14 molecule cleaved 2 that lacks the GPI-anchor." [PMID:2779588]


Yes
organism-modification



PR:000029986

CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]


organism-modification



PR:000035703

CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]

Yes

Yes
modification



PR:000002149

CD14 molecule cleaved 2 GPI-anchored form

CD14/Clv:2/anchored


"A CD14 molecule cleaved 2 that is the mature membrane-bound form of this protein. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [PMID:3385210, PRO:CNA]


Yes
organism-modification



PR:000035702

CD14 molecule cleaved 2 GPI-anchored form (human)

hCD14/Clv:2/anchored


"A CD14 molecule cleaved 2 GPI-anchored form in human. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]

Yes

Yes
organism-modification



PR:000037470

CD14 molecule cleaved 2 GPI-anchored form (mouse)

mCD14/Clv:2/anchored


"A CD14 molecule cleaved 2 GPI-anchored form in mouse. UniProtKB:P10810, 16-336, Asn-336, MOD:00167." [PMID:10601848, PMID:18606699, PRO:CNA]


Yes
organism-modification



PR:000036946

CD14 molecule cleaved 2 (mouse)

mCD14/Clv:2


"A CD14 molecule cleaved 2 in mouse. This represents both the GPI-anchored and soluble forms. UniProtKB:P10810, 16-336." [PRO:DAN]


organism-modification



PR:000029986

CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]


organism-modification



PR:000037470

CD14 molecule cleaved 2 GPI-anchored form (mouse)

mCD14/Clv:2/anchored


"A CD14 molecule cleaved 2 GPI-anchored form in mouse. UniProtKB:P10810, 16-336, Asn-336, MOD:00167." [PMID:10601848, PMID:18606699, PRO:CNA]


organism-modification



PR:000037480

CD14 molecule cleaved 2 (human)

hCD14/Clv:2


"A CD14 molecule cleaved 2 in human. This represents both the GPI-anchored and soluble forms. UniProtKB:P08571, 20-345." [PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000035702

CD14 molecule cleaved 2 GPI-anchored form (human)

hCD14/Clv:2/anchored


"A CD14 molecule cleaved 2 GPI-anchored form in human. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]

Yes

Yes
organism-modification



PR:000035703

CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]

Yes

Yes
modification



PR:000036849

CD14 molecule cleaved and soluble form

CD14/ClvPrd/soluble


"A CD14 molecule, signal peptide removed form that has been processed by proteolytic cleavage to yield the N-terminal domain lacking a GPI-anchor." [PRO:DAN]


Yes
modification



PR:000002146

CD14 molecule cleaved 1 soluble form

CD14/Clv:1/soluble


"A CD14 molecule, signal peptide removed form that lacks the GPI-anchor and has been processed by proteolytic cleavage to yield the N-terminal domain with extra C-terminal residues as compared to cleaved 2 form." [PMID:7519994]


organism-modification



PR:000036615

CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]

Yes

organism-modification



PR:000037469

CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]

Yes

modification



PR:000002147

CD14 molecule cleaved 2 soluble form

CD14/Clv:2/soluble


"A CD14 molecule cleaved 2 that lacks the GPI-anchor." [PMID:2779588]


organism-modification



PR:000029986

CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]


organism-modification



PR:000035703

CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]

Yes

Yes
organism-modification



PR:000036850

CD14 molecule cleaved and soluble form (mouse)

mCD14/ClvPrd/soluble


"A CD14 molecule cleaved and soluble form in mouse." [PRO:DAN]


Yes
organism-modification



PR:000029986

CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]


organism-modification



PR:000037469

CD14 molecule cleaved 1 soluble form (mouse)

mCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]


organism-modification



PR:000036945

CD14 molecule cleaved and soluble form (human)

hCD14/ClvPrd/soluble


"A CD14 molecule cleaved and soluble form in human." [PRO:DAN]


organism-modification



PR:000035703

CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble


"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]


organism-modification



PR:000036615

CD14 molecule cleaved 1 soluble form (human)

hCD14/Clv:1/soluble


"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]


organism-modification



PR:000050392

presepsin (human)

hPSEP


"A CD14 molecule, signal peptide removed form that has been cleaved by plasma proteases to yield a soluble 13kD N-terminal fragment in human." [PMID:16258819, PMID:21740312, PMID:25215141, PRO:DAN]


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CD14 forms found in complexes   

CD14 Component
Complexes
PR:000001889 CD14 PR:000037465 LPS:CD14 complex
PR:000002147 CD14/Clv:2/soluble PR:000025494 LPS:secreted CD14 alpha
PR:000025496 lipopolysaccharide receptor complex 2
PR:000025498 lipopolysaccharide receptor complex 4
PR:000002149 CD14/Clv:2/anchored PR:000025493 LPS:GPI-anchored CD14 complex
PR:000025495 lipopolysaccharide receptor complex 1
PR:000025497 lipopolysaccharide receptor complex 3
PR:000035702 hCD14/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000036849 CD14/ClvPrd/soluble PR:000029989 LPS:secreted CD14 complex
PR:000036850 mCD14/ClvPrd/soluble PR:000037467 LPS:secreted CD14 complex (mouse)
PR:000037470 mCD14/Clv:2/anchored PR:000037468 LPS:GPI-anchored CD14 complex (mouse)
PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000037480 hCD14/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:B0BL87 chick-CD14 PR:000037466 LPS:transmembrane CD14 complex (chicken)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035702 hCD14/Clv:2/anchored
UniProtKB:P08571, 20-345, Asn-345, MOD:00167
acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_inGO:0005886 plasma membrane Reactome:REACT_7740
GO:0005886 plasma membrane Reactome:REACT_7740
PR:000035703 hCD14/Clv:2/soluble acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
enablesGO:0001530 lipopolysaccharide binding PMID:9464818
located_inCL:0000129 microglial cell PMID:24659539
GO:0005576 extracellular region PMID:2779588; PMID:9665271
PR:000036615 hCD14/Clv:1/soluble
UniProtKB:P08571, 20-367
located_inGO:0005576 extracellular region PMID:7519994
PR:000036848 CD14/Clv:2
Example: UniProtKB:P08571, 20-345
acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI_ref:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI_ref:3836081; PMID:18854309
GO:0016020 membrane MGI_ref:3836081; PMID:18854309
PR:000037469 mCD14/Clv:1/soluble
UniProtKB:P10810, 16-358
located_inCL:0000129 microglial cell PMID:24659539
PR:B0BL87 chick-CD14 located_inGO:0005886 plasma membrane PMID:18761368
GO:0009986 cell surface PMID:18761368
PR:P08571 hCD14 located_inNOT CL:0000127 astrocyte PMID:24659539
PR:P10810 mCD14 located_inCL:0000127 astrocyte PMID:24659539