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Protein Ontology report - neuropilin-1
PR:000001900 - http://purl.obolibrary.org/obo/PR_000001900
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001900   
  PRO nameneuropilin-1 
  Synonyms
PRO-Short-label: EXACT:NRP1
Gene-based: RELATED:NRP | VEGF165R
Other: EXACT:A5 protein | BDCA-4 | blood dendritic cell antigen 4 | CD304 | vascular endothelial cell growth factor 165 receptor
RELATED:BDCA4
  Definition"A protein that is a translation product of the human NRP1 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification5                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000001900

neuropilin-1

NRP1


"A protein that is a translation product of the human NRP1 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:O14786

neuropilin-1 (human)

hNRP1


"A neuropilin-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O14786]


organism-sequence



PR:O14786-1

neuropilin-1 isoform 1 (human)

hNRP1/iso:1


"A neuropilin-1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000036635

neuropilin-1 isoform 1, signal peptide removed form (human)

hNRP1/iso:1/SigPep-


"A neuropilin-1 isoform 1, signal peptide removed form in human. UniProtKB:O14786-1, 22-923." [PMID:11986311, PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036631

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036632

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]

Yes

organism-sequence



PR:O14786-2

neuropilin-1 isoform 2 (human)

hNRP1/iso:2


"A neuropilin-1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:O14786-3

neuropilin-1 isoform h3 (human)

hNRP1/iso:h3


"A neuropilin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14786-3." [PRO:DNx, UniProtKB:O14786]


organism-modification



PR:000050705

neuropilin-1 N-glycosylated 1 (human)

hNRP1/NGlyco:1


"A neuropilin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-150 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:O14786-1, Asn-150, MOD:00160~GNO:G59626AS." [GlyGen:O14786-1, PMID:29671580, PRO:DNx]


organism-modification



PR:000050706

neuropilin-1 O-glycosylated 1 (human)

hNRP1/OGlyco:1


"A neuropilin-1 (human) that has been O-glycosylated at the residue equivalent to Ser-637 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O14786-1, Ser-637, MOD:00002~GNO:G53434XO." [GlyGen:O14786-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000050707

neuropilin-1 O-glycosylated 2 (human)

hNRP1/OGlyco:2


"A neuropilin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-589 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:O14786-1, Thr-589, MOD:00005~GNO:G57317CE." [GlyGen:O14786-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000050708

neuropilin-1 O-glycosylated 3 (human)

hNRP1/OGlyco:3


"A neuropilin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-638 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O14786-1, Thr-638, MOD:00005~GNO:G43417UB." [GlyGen:O14786-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000050709

neuropilin-1 O-glycosylated 4 (human)

hNRP1/OGlyco:4


"A neuropilin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-830 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O14786-1, Thr-830, MOD:00005~GNO:G43417UB." [GlyGen:O14786-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P79795

neuropilin-1 (chicken)

chick-NRP1


"A neuropilin-1 that is encoded in the genome of chicken." [OMA:P79795, PRO:DNx]


organism-gene



PR:P97333

neuropilin-1 (mouse)

mNRP1


"A neuropilin-1 that is encoded in the genome of mouse." [OMA:P97333, PRO:DNx]

Yes

organism-sequence



PR:P97333-1

neuropilin-1 isoform 1 (mouse)

mNRP1/iso:1


"A neuropilin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q8QFX6

neuropilin-1a (zebrafish)

z-NRP1


"A neuropilin-1 that is encoded in the genome of zebrafish." [OMA:Q8QFX6, PRO:DNx]


organism-gene



PR:Q9QWJ9

neuropilin-1 (rat)

rNRP1


"A neuropilin-1 that is encoded in the genome of rat." [OMA:Q9QWJ9, PRO:DNx]


sequence



PR:000003078

neuropilin-1 isoform 1

NRP1/iso:1


"A neuropilin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14786-1 or a 1:1 ortholog thereof." [PMID:9529250, PRO:CNA]


organism-sequence



PR:O14786-1

neuropilin-1 isoform 1 (human)

hNRP1/iso:1


"A neuropilin-1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000036635

neuropilin-1 isoform 1, signal peptide removed form (human)

hNRP1/iso:1/SigPep-


"A neuropilin-1 isoform 1, signal peptide removed form in human. UniProtKB:O14786-1, 22-923." [PMID:11986311, PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036631

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036632

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]

Yes

organism-sequence



PR:P97333-1

neuropilin-1 isoform 1 (mouse)

mNRP1/iso:1


"A neuropilin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000003095

neuropilin-1 isoform 1, signal peptide removed form

NRP1/iso:1/SigPep-


"A neuropilin-1 isoform 1 that has had the signal peptide removed to yield the mature protein." [PRO:DAN]


modification



PR:000003081

neuropilin-1 isoform 1, signal peptide removed glycosylated form

NRP1/iso:1/SigPep-/GlycoRes+


"A neuropilin-1 isoform 1, signal peptide removed form that has been post-translationally modified to include a glycosylated residue." [PRO:CNA]


modification



PR:000003082

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1

NRP1/iso:1/SigPep-/OGlyco:1


"A neuropilin-1 isoform 1, signal peptide removed glycosylated form that has a heparan sulfate moiety on a Ser residue located in the region between the F5/8 type C domain (Pfam:PF00754) and the MAM domain (Pfam:PF00629). Example: UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]


organism-modification



PR:000036631

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]

Yes

modification



PR:000003083

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2

NRP1/iso:1/SigPep-/OGlyco:2


"A neuropilin-1 isoform 1, signal peptide removed glycosylated form that has a chondroitin sulfate moiety on a Ser residue located in the region between the F5/8 type C domain (Pfam:PF00754) and the MAM domain (Pfam:PF00629). Example: UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]


organism-modification



PR:000036632

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036635

neuropilin-1 isoform 1, signal peptide removed form (human)

hNRP1/iso:1/SigPep-


"A neuropilin-1 isoform 1, signal peptide removed form in human. UniProtKB:O14786-1, 22-923." [PMID:11986311, PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036631

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036632

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]

Yes

sequence



PR:000003079

neuropilin-1 isoform 2

NRP1/iso:2


"A neuropilin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14786-2 or a 1:1 ortholog thereof." [PMID:10688880, PRO:CNA]


organism-sequence



PR:O14786-2

neuropilin-1 isoform 2 (human)

hNRP1/iso:2


"A neuropilin-1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000018583

neuropilin-1, signal peptide removed form

NRP1/SigPep-


"A neuropilin-1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000003095

neuropilin-1 isoform 1, signal peptide removed form

NRP1/iso:1/SigPep-


"A neuropilin-1 isoform 1 that has had the signal peptide removed to yield the mature protein." [PRO:DAN]


modification



PR:000003081

neuropilin-1 isoform 1, signal peptide removed glycosylated form

NRP1/iso:1/SigPep-/GlycoRes+


"A neuropilin-1 isoform 1, signal peptide removed form that has been post-translationally modified to include a glycosylated residue." [PRO:CNA]


modification



PR:000003082

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1

NRP1/iso:1/SigPep-/OGlyco:1


"A neuropilin-1 isoform 1, signal peptide removed glycosylated form that has a heparan sulfate moiety on a Ser residue located in the region between the F5/8 type C domain (Pfam:PF00754) and the MAM domain (Pfam:PF00629). Example: UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]


organism-modification



PR:000036631

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]

Yes

modification



PR:000003083

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2

NRP1/iso:1/SigPep-/OGlyco:2


"A neuropilin-1 isoform 1, signal peptide removed glycosylated form that has a chondroitin sulfate moiety on a Ser residue located in the region between the F5/8 type C domain (Pfam:PF00754) and the MAM domain (Pfam:PF00629). Example: UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]


organism-modification



PR:000036632

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036635

neuropilin-1 isoform 1, signal peptide removed form (human)

hNRP1/iso:1/SigPep-


"A neuropilin-1 isoform 1, signal peptide removed form in human. UniProtKB:O14786-1, 22-923." [PMID:11986311, PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036631

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]

Yes

organism-modification



PR:000036632

neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2


"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036631 hNRP1/iso:1/ClvOGlyco:1
UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215
acts_upstream_of_or_withinGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway PMID:16763549
enablesincreased GO:0005515 protein binding with PR:P15692-4 PMID:16763549
GO:0043184 vascular endothelial growth factor receptor 2 binding PMID:16763549
PR:000036632 hNRP1/iso:1/ClvOGlyco:2
UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213
acts_upstream_of_or_withinGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway PMID:16763549
enablesincreased GO:0005515 protein binding with PR:P15692-4 PMID:16763549
decreased GO:0043184 vascular endothelial growth factor receptor 2 binding relative to PR:000036635 hNRP1/iso:1/SigPep- PMID:16763549
PR:000036635 hNRP1/iso:1/SigPep-
UniProtKB:O14786-1, 22-923
enablesGO:0005515 protein binding with PR:P15692-4 PMID:11986311
GO:0005515 protein binding with PR:P15692-4 PMID:11986311
GO:0005515 protein binding with PR:P49763-3 PMID:11986311
GO:0008201 heparin binding PMID:11986311
GO:0043184 vascular endothelial growth factor receptor 2 binding PMID:16763549
PR:P97333 mNRP1 enablesGO:0005515 protein binding with PR:000036636 mVEGFB/iso:1/Clv:1 PMID:10409677
GO:0005515 protein binding with PR:P49766-2 PMID:10409677