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Protein Ontology report - tumor necrosis factor receptor superfamily member 6
PR:000001962 - http://purl.obolibrary.org/obo/PR_000001962
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001962   
  PRO nametumor necrosis factor receptor superfamily member 6 
  Synonyms
PRO-Short-label: EXACT:FAS
Gene-based: RELATED:APT1 | FAS1 | TNFRSF6
Other: EXACT:apo-1 antigen | apoptosis-mediating surface antigen FAS | CD95 | FASLG receptor
  Definition"A protein that is a translation product of the human FAS gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence7                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038809;IUPHARobj:1875
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000001962

tumor necrosis factor receptor superfamily member 6

FAS


"A protein that is a translation product of the human FAS gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P25445

tumor necrosis factor receptor superfamily member 6 (human)

hFAS


"A tumor necrosis factor receptor superfamily member 6 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P25445]


organism-sequence



PR:P25445-1

tumor necrosis factor receptor superfamily member 6 isoform 1 (human)

hFAS/iso:1


"A tumor necrosis factor receptor superfamily member 6 isoform 1 that is encoded in the genome of human." [PRO:JAN]

Yes

organism-sequence



PR:P25445-2

tumor necrosis factor receptor superfamily member 6 isoform 2 (human)

hFAS/iso:2


"A tumor necrosis factor receptor superfamily member 6 isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P25445-3

tumor necrosis factor receptor superfamily member 6 isoform 3 (human)

hFAS/iso:3


"A tumor necrosis factor receptor superfamily member 6 isoform 3 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P25445-4

tumor necrosis factor receptor superfamily member 6 isoform 4 (human)

hFAS/iso:4


"A tumor necrosis factor receptor superfamily member 6 isoform 4 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P25445-5

tumor necrosis factor receptor superfamily member 6 isoform 5 (human)

hFAS/iso:5


"A tumor necrosis factor receptor superfamily member 6 isoform 5 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P25445-6

tumor necrosis factor receptor superfamily member 6 isoform 6 (human)

hFAS/iso:6


"A tumor necrosis factor receptor superfamily member 6 isoform 6 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P25445-7

tumor necrosis factor receptor superfamily member 6 isoform 7 (human)

hFAS/iso:7


"A tumor necrosis factor receptor superfamily member 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25445-7." [PRO:DNx, UniProtKB:P25445]


organism-modification



PR:000047371

tumor necrosis factor receptor superfamily member 6, signal peptide removed form (human)

hFAS/SigPep-


"A tumor necrosis factor receptor superfamily member 6 (human) that has had the signal peptide removed. UniProtKB:P25445, 26-335." [PRO:DNx, Reactome:R-HSA-66248]


organism-modification



PR:000056274

tumor necrosis factor receptor superfamily member 6 O-glycosylated 1 (human)

hFAS/OGlyco:1


"A tumor necrosis factor receptor superfamily member 6 (human) that has been O-glycosylated at the residue equivalent to Thr-214 of the amino acid sequence represented by UniProtKB:P25445-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P25445-1, Thr-214, MOD:00005~GNO:G43417UB." [GlyGen:P25445-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056275

tumor necrosis factor receptor superfamily member 6 O-glycosylated 2 (human)

hFAS/OGlyco:2


"A tumor necrosis factor receptor superfamily member 6 (human) that has been O-glycosylated at the residue equivalent to Thr-28 of the amino acid sequence represented by UniProtKB:P25445-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P25445-1, Thr-28, MOD:00005~GNO:G43417UB." [GlyGen:P25445-1, PMID:22171320, PRO:DNx]


organism-modification



PR:000056276

tumor necrosis factor receptor superfamily member 6 O-glycosylated 3 (human)

hFAS/OGlyco:3


"A tumor necrosis factor receptor superfamily member 6 (human) that has been O-glycosylated at the residue equivalent to Thr-40 of the amino acid sequence represented by UniProtKB:P25445-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:P25445-1, Thr-40, MOD:00005~GNO:G57317CE." [GlyGen:P25445-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056277

tumor necrosis factor receptor superfamily member 6 O-glycosylated 4 (human)

hFAS/OGlyco:4


"A tumor necrosis factor receptor superfamily member 6 (human) that has been O-glycosylated at the residue equivalent to Thr-46 of the amino acid sequence represented by UniProtKB:P25445-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P25445-1, Thr-46, MOD:00005~GNO:G29068FM." [GlyGen:P25445-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056278

tumor necrosis factor receptor superfamily member 6 O-glycosylated 5 (human)

hFAS/OGlyco:5


"A tumor necrosis factor receptor superfamily member 6 (human) that has been O-glycosylated at the residue equivalent to Thr-46 of the amino acid sequence represented by UniProtKB:P25445-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P25445-1, Thr-46, MOD:00005~GNO:G43417UB." [GlyGen:P25445-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P25446

tumor necrosis factor receptor superfamily member 6 (mouse)

mFAS


"A tumor necrosis factor receptor superfamily member 6 that is encoded in the genome of mouse." [OMA:P25446, PRO:DNx]


organism-gene



PR:Q63199

tumor necrosis factor receptor superfamily member 6 (rat)

rFAS


"A tumor necrosis factor receptor superfamily member 6 that is encoded in the genome of rat." [OMA:Q63199, PRO:DNx]


sequence



PR:000002358

tumor necrosis factor receptor superfamily member 6 isoform 1

FAS/iso:1


"A tumor necrosis factor receptor superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25445-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P25445-1

tumor necrosis factor receptor superfamily member 6 isoform 1 (human)

hFAS/iso:1


"A tumor necrosis factor receptor superfamily member 6 isoform 1 that is encoded in the genome of human." [PRO:JAN]

Yes

sequence



PR:000002359

tumor necrosis factor receptor superfamily member 6 isoform 2

FAS/iso:2


"A tumor necrosis factor receptor superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25445-2 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P25445-2

tumor necrosis factor receptor superfamily member 6 isoform 2 (human)

hFAS/iso:2


"A tumor necrosis factor receptor superfamily member 6 isoform 2 that is encoded in the genome of human." [PRO:JAN]


sequence



PR:000002360

tumor necrosis factor receptor superfamily member 6 isoform 3

FAS/iso:3


"A tumor necrosis factor receptor superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25445-3 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P25445-3

tumor necrosis factor receptor superfamily member 6 isoform 3 (human)

hFAS/iso:3


"A tumor necrosis factor receptor superfamily member 6 isoform 3 that is encoded in the genome of human." [PRO:JAN]


sequence



PR:000002361

tumor necrosis factor receptor superfamily member 6 isoform 4

FAS/iso:4


"A tumor necrosis factor receptor superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25445-4 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P25445-4

tumor necrosis factor receptor superfamily member 6 isoform 4 (human)

hFAS/iso:4


"A tumor necrosis factor receptor superfamily member 6 isoform 4 that is encoded in the genome of human." [PRO:JAN]


sequence



PR:000002362

tumor necrosis factor receptor superfamily member 6 isoform 5

FAS/iso:5


"A tumor necrosis factor receptor superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25445-5 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P25445-5

tumor necrosis factor receptor superfamily member 6 isoform 5 (human)

hFAS/iso:5


"A tumor necrosis factor receptor superfamily member 6 isoform 5 that is encoded in the genome of human." [PRO:JAN]


sequence



PR:000002363

tumor necrosis factor receptor superfamily member 6 isoform 6

FAS/iso:6


"A tumor necrosis factor receptor superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25445-6 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P25445-6

tumor necrosis factor receptor superfamily member 6 isoform 6 (human)

hFAS/iso:6


"A tumor necrosis factor receptor superfamily member 6 isoform 6 that is encoded in the genome of human." [PRO:JAN]


sequence



PR:000002364

tumor necrosis factor receptor superfamily member 6 isoform 7

FAS/iso:7


"A tumor necrosis factor receptor superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25445-7 or a 1:1 ortholog thereof." [PRO:JAN]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P25445-1 hFAS/iso:1 acts_upstream_of_or_withinGO:0070231 T cell apoptotic process PMID:14739941
enablesGO:0005515 protein binding with PR:P15311 cytovillin (human) PMID:14739941
located_inGO:0005886 plasma membrane PMID:14739941