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Protein Ontology report - DNA-binding protein Ikaros isoform 1
PR:000002150 - http://purl.obolibrary.org/obo/PR_000002150
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002150   
  PRO nameDNA-binding protein Ikaros isoform 1 
  Synonyms
PRO-Short-label: EXACT:IKZF1/iso:1
Other: EXACT:DNA-binding protein Ikaros isoform Ik1 | DNA-binding protein Ikaros isoform VI
  Definition"A DNA-binding protein Ikaros that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03267-1 or a 1:1 ortholog thereof." [PRO:HJD] 
  PRO Categorysequence 
  ParentPR:000001811 DNA-binding protein Ikaros
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
sequence


PR:000002150 DNA-binding protein Ikaros isoform 1
IKZF1/iso:1

organism-sequence


PR:Q03267-1 DNA-binding protein Ikaros isoform VI (mouse)
mIKZF1/iso:VI
Yes
organism-sequence


PR:Q13422-1 DNA-binding protein Ikaros isoform Ik1 (human)
hIKZF1/iso:Ik1

modification


PR:000018259 DNA-binding protein Ikaros isoform 1 phosphorylated form
IKZF1/iso:1/PhosRes+

modification


PR:000018260 DNA-binding protein Ikaros isoform 1 phosphorylated 1
IKZF1/iso:1/Phos:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q03267-1 mIKZF1/iso:VI acts_upstream_of_or_withinGO:0000122 negative regulation of transcription by RNA polymerase II PMID:12617992
GO:0001779 natural killer cell differentiation PMID:7923373
GO:0051138 positive regulation of NK T cell differentiation MGI_ref:1340364; PMID:10366784
GO:0060041 retina development in camera-type eye MGI_ref:3831471; PMID:18940586
enablesGO:0046982 protein heterodimerization activity with PR:P81183-1|PR:P81183-2 MGI_ref:1333610; PMID:10218586
GO:0046982 protein heterodimerization activity with PR:Q8C208-1 MGI_ref:1333610; PMID:10218586
located_inGO:0005634 nucleus MGI_ref:2652944; PMID:12617992