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Protein Ontology report - Bcl-2-like apoptosis inhibitor
PR:000002186 - http://purl.obolibrary.org/obo/PR_000002186
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002186   
  PRO nameBcl-2-like apoptosis inhibitor 
  Definition"A protein that is a translation product of the human BCL2, BCL2L1, or BCL2L2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The core domain architecture consists of an amino-terminal BH4 domain (Pfam:PF02180), which confers apoptosis inhibitory activity, and a Bcl-2 domain (Pfam:PF02180) common to many apoptosis regulator proteins." [PRO:DAN, PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 11                                        
         Sequence8                                                  Organism-Sequence 20                                        
         Modification6                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF001714
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000002186 Bcl-2-like apoptosis inhibitor
BAK1

gene


PR:000002307 apoptosis regulator Bcl-2
BCL2

organism-gene


PR:P10415 apoptosis regulator Bcl-2 (human)
hBCL2

organism-sequence


PR:P10415-1 apoptosis regulator Bcl-2 isoform Alpha (human)
hBCL2/iso:Alpha
Yes
organism-modification


PR:000027461 apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
hBCL2/iso:1/Phos:2
Yes
organism-modification


PR:000027463 apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
hBCL2/iso:1/Phos:3
Yes
organism-modification


PR:000027465 apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
hBCL2/iso:1/Phos:4
Yes
organism-modification


PR:000027467 apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
hBCL2/iso:1/Phos:5
Yes
organism-sequence


PR:P10415-2 apoptosis regulator Bcl-2 isoform Beta (human)
hBCL2/iso:Beta

organism-modification


PR:000070038 apoptosis regulator Bcl-2 methylated 1 (human)
hBCL2/Me:1

organism-modification


PR:000082889 apoptosis regulator Bcl-2 cysteinylated 1 (human)
hBCL2/Cyst:1

organism-gene


PR:P10417 apoptosis regulator Bcl-2 (mouse)
mBCL2

organism-sequence


PR:P10417-1 apoptosis regulator Bcl-2 isoform Alpha (mouse)
mBCL2/iso:Alpha
Yes
organism-modification


PR:000036633 apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)
mBCL2/iso:1/Phos:1
Yes
organism-sequence


PR:P10417-2 apoptosis regulator Bcl-2 isoform Beta (mouse)
mBCL2/iso:Beta

organism-gene


PR:P49950 apoptosis regulator Bcl-2 (rat)
rBCL2

organism-gene


PR:Q00709 apoptosis regulator Bcl-2 (chicken)
chick-BCL2

sequence


PR:000002383 apoptosis regulator Bcl-2 isoform 1
BCL2/iso:1

organism-sequence


PR:P10415-1 apoptosis regulator Bcl-2 isoform Alpha (human)
hBCL2/iso:Alpha
Yes
organism-modification


PR:000027461 apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
hBCL2/iso:1/Phos:2
Yes
organism-modification


PR:000027463 apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
hBCL2/iso:1/Phos:3
Yes
organism-modification


PR:000027465 apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
hBCL2/iso:1/Phos:4
Yes
organism-modification


PR:000027467 apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
hBCL2/iso:1/Phos:5
Yes
organism-sequence


PR:P10417-1 apoptosis regulator Bcl-2 isoform Alpha (mouse)
mBCL2/iso:Alpha
Yes
organism-modification


PR:000036633 apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)
mBCL2/iso:1/Phos:1
Yes
modification


PR:000003088 apoptosis regulator Bcl-2 isoform 1 phosphorylated form
BCL2/iso:1/PhosRes+

modification


PR:000003089 apoptosis regulator Bcl-2 isoform 1 phosphorylated 1
BCL2/iso:1/Phos:1

organism-modification


PR:000036633 apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)
mBCL2/iso:1/Phos:1
Yes
modification


PR:000027460 apoptosis regulator Bcl-2 isoform 1 phosphorylated 2
BCL2/iso:1/Phos:2

organism-modification


PR:000027461 apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
hBCL2/iso:1/Phos:2
Yes
modification


PR:000027462 apoptosis regulator Bcl-2 isoform 1 phosphorylated 3
BCL2/iso:1/Phos:3

organism-modification


PR:000027463 apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
hBCL2/iso:1/Phos:3
Yes
modification


PR:000027464 apoptosis regulator Bcl-2 isoform 1 phosphorylated 4
BCL2/iso:1/Phos:4

organism-modification


PR:000027465 apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
hBCL2/iso:1/Phos:4
Yes
modification


PR:000027466 apoptosis regulator Bcl-2 isoform 1 phosphorylated 5
BCL2/iso:1/Phos:5

organism-modification


PR:000027467 apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
hBCL2/iso:1/Phos:5
Yes
sequence


PR:000002384 apoptosis regulator Bcl-2 isoform 2
BCL2/iso:2

organism-sequence


PR:P10415-2 apoptosis regulator Bcl-2 isoform Beta (human)
hBCL2/iso:Beta

organism-sequence


PR:P10417-2 apoptosis regulator Bcl-2 isoform Beta (mouse)
mBCL2/iso:Beta

gene


PR:000002308 Bcl-2-like protein 1
BCL2L1

organism-gene


PR:P53563 Bcl-2-like protein 1 (rat)
rBCL2L1

organism-sequence


PR:P53563-1 Bcl-2-like protein 1 isoform Bcl-X(L) (rat)
rBcl2l1/iso:Bcl-X(L)

organism-sequence


PR:P53563-2 Bcl-2-like protein 1 isoform Bcl-X(S) (rat)
rBCL2L1/iso:Bcl-X(S)

organism-sequence


PR:P53563-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (rat)
rBCL2L1/iso:Bcl-X(beta)

organism-gene


PR:Q07816 Bcl-2-like protein 1 (chicken)
chick-BCL2L1

organism-sequence


PR:Q07816-1 Bcl-2-like protein 1 isoform Long (chicken)
chick-BCL2L1/iso:Long

organism-sequence


PR:Q07816-2 Bcl-2-like protein 1 isoform Short (chicken)
chick-BCL2L1/iso:Short

organism-gene


PR:Q07817 Bcl-2-like protein 1 (human)
hBCL2L1

organism-sequence


PR:Q07817-1 Bcl-2-like protein 1 isoform 1 (human)
hBCL2L1/iso:1
Yes
organism-sequence


PR:Q07817-2 Bcl-2-like protein 1 isoform Bcl-X(S) (human)
hBCL2L1/iso:Bcl-X(S)

organism-sequence


PR:Q07817-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (human)
hBCL2L1/iso:Bcl-X(beta)

organism-modification


PR:000045887 Bcl-2-like protein 1 phosphorylated 1 (human)
hBCL2L1/Phos:1

organism-gene


PR:Q64373 Bcl-2-like protein 1 (mouse)
mBCL2L1

organism-sequence


PR:Q64373-1 Bcl-2-like protein 1 isoform Bcl-X(L) (mouse)
mBCL2L1/iso:Bcl-X(L)
Yes
organism-sequence


PR:Q64373-2 Bcl-2-like protein 1 isoform Bcl-X(S) (mouse)
mBCL2L1/iso:Bcl-X(S)
Yes
organism-sequence


PR:Q64373-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (mouse)
mBCL2L1/iso:Bcl-X(beta)

organism-sequence


PR:Q64373-4 Bcl-2-like protein 1 isoform Bcl-X(delta-TM) (mouse)
mBCL2L1/iso:Bcl-X(delta-TM)

sequence


PR:000002385 Bcl-2-like protein 1 isoform 1
BCL2L1/iso:1

organism-sequence


PR:Q07817-1 Bcl-2-like protein 1 isoform 1 (human)
hBCL2L1/iso:1
Yes
organism-sequence


PR:Q64373-1 Bcl-2-like protein 1 isoform Bcl-X(L) (mouse)
mBCL2L1/iso:Bcl-X(L)
Yes
sequence


PR:000002386 Bcl-2-like protein 1 isoform 2
BCL2L1/iso:2

organism-sequence


PR:Q07817-2 Bcl-2-like protein 1 isoform Bcl-X(S) (human)
hBCL2L1/iso:Bcl-X(S)

organism-sequence


PR:Q64373-2 Bcl-2-like protein 1 isoform Bcl-X(S) (mouse)
mBCL2L1/iso:Bcl-X(S)
Yes
sequence


PR:000002387 Bcl-2-like protein 1 isoform 3
BCL2L1/iso:3

organism-sequence


PR:Q07817-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (human)
hBCL2L1/iso:Bcl-X(beta)

sequence


PR:000002388 Bcl-2-like protein 1 isoform 4
BCL2L1/iso:4

organism-sequence


PR:Q64373-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (mouse)
mBCL2L1/iso:Bcl-X(beta)

sequence


PR:000002389 Bcl-2-like protein 1 isoform 5
BCL2L1/iso:5

organism-sequence


PR:Q64373-4 Bcl-2-like protein 1 isoform Bcl-X(delta-TM) (mouse)
mBCL2L1/iso:Bcl-X(delta-TM)

gene


PR:000004698 Bcl-2-like protein 2
BCL2L2

organism-gene


PR:000036332 Bcl-2-like protein 2 (human)
hBCL2L2

organism-sequence


PR:Q92843-1 Bcl-2-like protein 2 isoform 1 (human)
hBCL2L2/iso:1

organism-gene


PR:O88996 BCL-W (rat)
rBCL2L2

organism-sequence


PR:O88996-1 Bcl-2-like protein 2 isoform 1 (rat)
rBCL2L2/iso:1

organism-gene


PR:P70345 Bcl-2-like protein 2 (mouse)
mBCL2L2

organism-sequence


PR:P70345-1 Bcl-2-like protein 2 isoform 1 (mouse)
mBCL2L2/iso:1

organism-sequence


PR:P70345-2 Bcl-2-like protein 2 isoform m2 (mouse)
mBCL2L2/iso:m2

sequence


PR:000042349 Bcl-2-like protein 2 isoform 1
BCL2L2/iso:1

organism-sequence


PR:O88996-1 Bcl-2-like protein 2 isoform 1 (rat)
rBCL2L2/iso:1

organism-sequence


PR:P70345-1 Bcl-2-like protein 2 isoform 1 (mouse)
mBCL2L2/iso:1

organism-sequence


PR:Q92843-1 Bcl-2-like protein 2 isoform 1 (human)
hBCL2L2/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027461 hBCL2/iso:1/Phos:2
UniProtKB:P10415-1, Thr-74, MOD:00047		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:12039864
PR:000027463 hBCL2/iso:1/Phos:3
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046		 acts_upstream_of_or_withinGO:0016239 positive regulation of macroautophagy PMID:18570871; PMID:19029119
enablesNOT GO:0005515 protein binding with PR:Q14457 BECN1 PMID:18570871; PMID:19029119
PR:000027465 hBCL2/iso:1/Phos:4
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046		 acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process PMID:15703383
PR:000027467 hBCL2/iso:1/Phos:5
UniProtKB:P10415-1, Thr-56, MOD:00047		 acts_upstream_of_or_withinGO:0045839 negative regulation of mitotic nuclear division PMID:10766756
PR:000036633 mBCL2/iso:1/Phos:1
UniProtKB:P10417-1, Ser-70, MOD:00046		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:9115213; PMID:9852076
enablesGO:0005515 protein binding with PR:Q07813 Bax PMID:9115213; PMID:9852076
GO:0019902 phosphatase binding PMID:9115213; PMID:9852076
located_inGO:0016020 membrane PMID:9115213; PMID:9852076
PR:P10415-1 hBCL2/iso:Alpha acts_upstream_of_or_withinGO:0070885 negative regulation of calcineurin-NFAT signaling cascade PMID:9109491
enablesGO:0005515 protein binding with PR:P63328 calcineurin A alpha (mouse) PMID:9109491
GO:0005515 protein binding with PR:Q07813 Bax PMID:9109491
located_inGO:0005886 plasma membrane PMID:9109491
PR:P10417-1 mBCL2/iso:Alpha acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:11583631
enablesGO:0005515 protein binding with PR:000026785 mBID/iso:1/Clv:1 PMID:11583631
PR:Q07817-1 hBCL2L1/iso:1 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:10949026
GO:0043066 negative regulation of apoptotic process PMID:8596636
enablesNOT GO:0005515 protein binding with PR:000028379 hBID/iso:1/Clv:1 PMID:10949026
NOT GO:0005515 protein binding with PR:O54918 Bcl2-interacting mediator of cell death (mouse) PMID:10949026
NOT GO:0005515 protein binding with PR:Q07812 BAX PMID:10949026
NOT GO:0005515 protein binding with PR:Q16611 apoptosis regulator BAK (human) PMID:10949026
NOT GO:0005515 protein binding with PR:Q61337 Bad PMID:10949026
NOT GO:0005515 protein binding with PR:Q92934-1 PMID:10949026
NOT GO:0005515 protein binding with PR:000026167 mBAD/iso:1/Phos:1 PMID:10949026
NOT GO:0005515 protein binding with PR:000026133 mBAD/iso:1/Phos:2 PMID:10949026
PR:Q64373-1 mBCL2L1/iso:Bcl-X(L) acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process MGI_ref:81233; PMID:8798158
GO:0043066 negative regulation of apoptotic process MGI_ref:81233; PMID:8798158
associated_with_disease_progressionDO:162 cancer PMID:16403219
enablesGO:0005515 protein binding with PR:O08734 apoptosis regulator BAK (mouse) MGI_ref:3804133; PMID:16705087
GO:0046982 protein heterodimerization activity MGI_ref:82784; PMID:8798452
PR:Q64373-2 mBCL2L1/iso:Bcl-X(S) acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process MGI_ref:81233; PMID:8798158