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RACE-PRO
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Documentation
Protein Ontology report - apoptosis regulator Bcl-2 isoform 1
PR:000002383 -
http://purl.obolibrary.org/obo/PR_000002383
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000002383
PRO name
apoptosis regulator Bcl-2 isoform 1
Synonyms
PRO-Short-label
:
EXACT:
BCL2/iso:1
Other
:
EXACT:
Bcl2 isoform alpha
Definition
"An apoptosis regulator Bcl-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:P10417-1
or a 1:1 ortholog thereof." [
PMID:2834197
,
PMID:2875799
, PRO:JAN]
PRO Category
sequence
Parent
PR:000002307
apoptosis regulator Bcl-2
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
6
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
sequence
PR:000002383
apoptosis regulator Bcl-2 isoform 1
BCL2/iso:1
organism-sequence
PR:P10415-1
apoptosis regulator Bcl-2 isoform Alpha (human)
hBCL2/iso:Alpha
Yes
organism-modification
PR:000027461
apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
hBCL2/iso:1/Phos:2
Yes
organism-modification
PR:000027463
apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
hBCL2/iso:1/Phos:3
Yes
organism-modification
PR:000027465
apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
hBCL2/iso:1/Phos:4
Yes
organism-modification
PR:000027467
apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
hBCL2/iso:1/Phos:5
Yes
organism-sequence
PR:P10417-1
apoptosis regulator Bcl-2 isoform Alpha (mouse)
mBCL2/iso:Alpha
Yes
organism-modification
PR:000036633
apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)
mBCL2/iso:1/Phos:1
Yes
modification
PR:000003088
apoptosis regulator Bcl-2 isoform 1 phosphorylated form
BCL2/iso:1/PhosRes+
modification
PR:000003089
apoptosis regulator Bcl-2 isoform 1 phosphorylated 1
BCL2/iso:1/Phos:1
organism-modification
PR:000036633
apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)
mBCL2/iso:1/Phos:1
Yes
modification
PR:000027460
apoptosis regulator Bcl-2 isoform 1 phosphorylated 2
BCL2/iso:1/Phos:2
organism-modification
PR:000027461
apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
hBCL2/iso:1/Phos:2
Yes
modification
PR:000027462
apoptosis regulator Bcl-2 isoform 1 phosphorylated 3
BCL2/iso:1/Phos:3
organism-modification
PR:000027463
apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
hBCL2/iso:1/Phos:3
Yes
modification
PR:000027464
apoptosis regulator Bcl-2 isoform 1 phosphorylated 4
BCL2/iso:1/Phos:4
organism-modification
PR:000027465
apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
hBCL2/iso:1/Phos:4
Yes
modification
PR:000027466
apoptosis regulator Bcl-2 isoform 1 phosphorylated 5
BCL2/iso:1/Phos:5
organism-modification
PR:000027467
apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
hBCL2/iso:1/Phos:5
Yes
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0016239
positive regulation of macroautophagy
PR:000027463
hBCL2/iso:1/Phos:3
PMID:18570871
;
PMID:19029119
GO:0043065
positive regulation of apoptotic process
PR:000027465
hBCL2/iso:1/Phos:4
PMID:15703383
GO:0043066
negative regulation of apoptotic process
PR:000027461
hBCL2/iso:1/Phos:2
PMID:12039864
PR:000036633
mBCL2/iso:1/Phos:1
PMID:9115213
;
PMID:9852076
PR:P10417-1
mBCL2/iso:Alpha
PMID:11583631
GO:0045839
negative regulation of mitotic nuclear division
PR:000027467
hBCL2/iso:1/Phos:5
PMID:10766756
GO:0070885
negative regulation of calcineurin-NFAT signaling cascade
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515
protein binding
PR:000036633
mBCL2/iso:1/Phos:1
PMID:9115213
;
PMID:9852076
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
PR:P10417-1
mBCL2/iso:Alpha
PMID:11583631
NOT
GO:0005515
protein binding
PR:000027463
hBCL2/iso:1/Phos:3
PMID:18570871
;
PMID:19029119
GO:0019902
phosphatase binding
PR:000036633
mBCL2/iso:1/Phos:1
PMID:9115213
;
PMID:9852076
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886
plasma membrane
PR:P10415-1
hBCL2/iso:Alpha
PMID:9109491
GO:0016020
membrane
PR:000036633
mBCL2/iso:1/Phos:1
PMID:9115213
;
PMID:9852076
