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Protein Ontology report - NRAMP-like divalent ion transporter
PR:000002992 - http://purl.obolibrary.org/obo/PR_000002992
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002992   
  PRO nameNRAMP-like divalent ion transporter 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 13                                        
         Sequence2                                                  Organism-Sequence 18                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF005717
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
family



PR:000002992

NRAMP-like divalent ion transporter

IKZF4/iso:4





gene



PR:000002993

natural resistance-associated macrophage protein 2

SLC11A2


"An NRAMP-like divalent ion transporter that is a translation product of the human SLC11A2 gene or a 1:1 ortholog thereof." [PRO:HJD]


organism-gene



PR:B3F8C5

NRAMP2 isoform 1 (chicken)

chick-SLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of chicken." [PANTHER:PTHR11706:SF7, PRO:DNx]


organism-gene



PR:O54902

natural resistance-associated macrophage protein 2 (rat)

rSLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of rat." [OMA:O54902, PRO:DNx]


organism-sequence



PR:O54902-1

natural resistance-associated macrophage protein 2 isoform r2 (rat)

rSLC11A2/iso:r2


"A natural resistance-associated macrophage protein 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O54902-1." [PRO:DNx, UniProtKB:O54902]


organism-sequence



PR:O54902-2

natural resistance-associated macrophage protein 2 isoform r1 (rat)

rSLC11A2/iso:r1


"A natural resistance-associated macrophage protein 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O54902-2." [PRO:DNx, UniProtKB:O54902]


organism-gene



PR:P49281

natural resistance-associated macrophage protein 2 (human)

hSLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of human." [PRO:HJD, UniProtKB:P49281]


organism-sequence



PR:000063697

natural resistance-associated macrophage protein 2 sequence variant G212V (human)

hSLC11A2/var:G212V


"A natural resistance-associated macrophage protein 2 (human) that has a Val residue at the position equivalent to Gly-212 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Gly-212, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-5623771]


organism-sequence



PR:000063872

natural resistance-associated macrophage protein 2 sequence variant R416C (human)

hSLC11A2/var:R416C


"A natural resistance-associated macrophage protein 2 (human) that has a Cys residue at the position equivalent to Arg-416 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Arg-416, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-5623758]


organism-sequence



PR:000064631

natural resistance-associated macrophage protein 2 sequence variant E399D (human)

hSLC11A2/var:E399D


"A natural resistance-associated macrophage protein 2 (human) that has an Asp residue at the position equivalent to Glu-399 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Glu-399, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-5623732]


organism-sequence



PR:P49281-1

natural resistance-associated macrophage protein 2 isoform 2 (human)

hSLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 isoform 2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49281-2

natural resistance-associated macrophage protein 2 isoform 1 (human)

hSLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49281-3

natural resistance-associated macrophage protein 2 isoform h3 (human)

hSLC11A2/iso:h3


"A natural resistance-associated macrophage protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49281-3." [PRO:DNx, UniProtKB:P49281]


organism-sequence



PR:P49281-4

natural resistance-associated macrophage protein 2 isoform h4 (human)

hSLC11A2/iso:h4


"A natural resistance-associated macrophage protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49281-4." [PRO:DNx, UniProtKB:P49281]


organism-sequence



PR:P49281-5

natural resistance-associated macrophage protein 2 isoform h5 (human)

hSLC11A2/iso:h5


"A natural resistance-associated macrophage protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49281-5." [PRO:DNx, UniProtKB:P49281]


organism-modification



PR:000074463

natural resistance-associated macrophage protein 2 deaminated 1 (human)

hSLC11A2/Deam:1


"A natural resistance-associated macrophage protein 2 (human) that has been deaminated on the residue at the position equivalent to Asn-443 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Asn-443, MOD:00684." [IEDB_epitope:1331246, PRO:DNx]


organism-modification



PR:000076056

natural resistance-associated macrophage protein 2 deaminated 2 (human)

hSLC11A2/Deam:2


"A natural resistance-associated macrophage protein 2 (human) that has been deaminated on the residue at the position equivalent to Gln-395 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Gln-395, MOD:00685." [IEDB_epitope:1586697, PRO:DNx]


organism-modification



PR:000080800

natural resistance-associated macrophage protein 2 deaminated 3 (human)

hSLC11A2/Deam:3


"A natural resistance-associated macrophage protein 2 (human) that has been deaminated on the residue at the position equivalent to Asn-311 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Asn-311, MOD:00684." [IEDB_epitope:1986448, PRO:DNx]


organism-gene



PR:P49282

natural resistance-associated macrophage protein 2 (mouse)

mSLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of mouse." [OMA:P49282, PRO:DNx]

Yes

organism-sequence



PR:P49282-1

natural resistance-associated macrophage protein 2 isoform 2 (mouse)

mSLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-sequence



PR:P49282-2

natural resistance-associated macrophage protein 2 isoform 1 (mouse)

mSLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-sequence



PR:P49282-3

natural resistance-associated macrophage protein 2 isoform m3 (mouse)

mSLC11A2/iso:m3


"A natural resistance-associated macrophage protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-3." [PRO:DNx, UniProtKB:P49282]


organism-sequence



PR:P49282-4

natural resistance-associated macrophage protein 2 isoform m4 (mouse)

mSLC11A2/iso:m4


"A natural resistance-associated macrophage protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-4." [PRO:DNx, UniProtKB:P49282]


organism-gene



PR:P49283

protein Malvolio (fruit fly)

fly-SLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of fruit fly." [OMA:P49283, PRO:DNx]


organism-sequence



PR:P49283-1

protein Malvolio isoform C (fruit fly)

fly-SLC11A2/iso:C


"A protein Malvolio (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49283-1." [PRO:DNx, UniProtKB:P49283]


organism-sequence



PR:P49283-2

protein Malvolio isoform A (fruit fly)

fly-SLC11A2/iso:A


"A protein Malvolio (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49283-2." [PRO:DNx, UniProtKB:P49283]


organism-gene



PR:Q869V1

metal transporter nramp1 homolog (Dictyostelium discoideum)

Dicty-SLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q869V1, PRO:DNx]


sequence



PR:000002995

natural resistance-associated macrophage protein 2 isoform 1

SLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-2 or a 1:1 ortholog thereof." [PMID:7789986, PRO:HJD]


organism-sequence



PR:P49281-2

natural resistance-associated macrophage protein 2 isoform 1 (human)

hSLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49282-2

natural resistance-associated macrophage protein 2 isoform 1 (mouse)

mSLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

sequence



PR:000002996

natural resistance-associated macrophage protein 2 isoform 2

SLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-1 or a 1:1 ortholog thereof." [PRO:HJD]


organism-sequence



PR:P49281-1

natural resistance-associated macrophage protein 2 isoform 2 (human)

hSLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 isoform 2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49282-1

natural resistance-associated macrophage protein 2 isoform 2 (mouse)

mSLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]

Yes

gene



PR:000002994

natural resistance-associated macrophage protein 1

SLC11A1


"An NRAMP-like divalent ion transporter that is a translation product of the human SLC11A1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P41251

natural resistance-associated macrophage protein 1 (mouse)

mSLC11A1


"A natural resistance-associated macrophage protein 1 that is encoded in the genome of mouse." [OMA:P41251, PRO:DNx]


organism-gene



PR:P49279

natural resistance-associated macrophage protein 1 (human)

hSLC11A1


"A natural resistance-associated macrophage protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P49279]


organism-sequence



PR:P49279-1

natural resistance-associated macrophage protein 1 isoform h1 (human)

hSLC11A1/iso:h1


"A natural resistance-associated macrophage protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49279-1." [PRO:DNx, UniProtKB:P49279]


organism-sequence



PR:P49279-2

natural resistance-associated macrophage protein 1 isoform h2 (human)

hSLC11A1/iso:h2


"A natural resistance-associated macrophage protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49279-2." [PRO:DNx, UniProtKB:P49279]


organism-gene



PR:P51027

natural resistance-associated macrophage protein 1 (chicken)

chick-SLC11A1


"A natural resistance-associated macrophage protein 1 that is encoded in the genome of chicken." [OMA:P51027, PRO:DNx]


organism-gene



PR:P70553

natural resistance-associated macrophage protein 1 (rat)

rSLC11A1


"A natural resistance-associated macrophage protein 1 that is encoded in the genome of rat." [OMA:P70553, PRO:DNx]


gene



PR:000023258

divalent metal cation transporter MntH

mntH


"An NRAMP-like divalent ion transporter that is a translation product of the Escherichia coli K-12 mntH gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P0A769

divalent metal cation transporter MntH (Escherichia coli K-12)

Ec-mntH


"A divalent metal cation transporter MntH that is encoded in the genome of Escherichia coli K-12." [PRO:DNx, UniProtKB:P0A769]


organism-gene



PR:Q10177

manganese transporter pdt1 (Schizosaccharomyces pombe 972h-)

Spom972h-mntH


"A divalent metal cation transporter MntH that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q10177, PRO:DNx]


organism-gene



PR:Q2G2G3

divalent metal cation transporter MntH (Staphylococcus aureus subsp. aureus NCTC 8325)

mntH (STAA8)


"A divalent metal cation transporter MntH that is encoded in the genome of Staphylococcus aureus subsp. aureus NCTC 8325." [OMA:Q2G2G3, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P49282 mSLC11A2 acts_upstream_of_or_withinGO:0006778 porphyrin-containing compound metabolic process PMID:4404581
GO:0006826 iron ion transport PMID:807277
GO:0007611 learning or memory PMID:19211831
GO:0048813 dendrite morphogenesis PMID:19211831
GO:0048821 erythrocyte development PMID:15849611
GO:0060586 multicellular organismal-level iron ion homeostasis PMID:5070129
PR:P49282-1 mSLC11A2/iso:2 acts_upstream_of_or_withinGO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006826 iron ion transport MGI_ref:3849744; PMID:10942769
GO:0006826 iron ion transport MGI_ref:3849744; PMID:10942769
GO:1902600 proton transmembrane transport MGI_ref:3037617; PMID:15024413
enablesGO:0015078 proton transmembrane transporter activity MGI_ref:3037617; PMID:15024413
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3849744; PMID:10942769
located_inGO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0009986 cell surface MGI_ref:3695635; PMID:17097837
GO:0055037 recycling endosome MGI_ref:3695780; PMID:16905747
GO:0055037 recycling endosome MGI_ref:3695780; PMID:16905747
PR:P49282-2 mSLC11A2/iso:1 acts_upstream_of_or_withinGO:0006824 cobalt ion transport MGI_ref:3603092; PMID:16142913
GO:0006826 iron ion transport MGI_ref:3603092; PMID:16142913
GO:0033212 iron import into cell MGI_ref:3037617; PMID:15024413
enablesGO:0005381 iron ion transmembrane transporter activity MGI_ref:3603092; PMID:16142913
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3603092; PMID:16142913
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3037617; PMID:15024413
located_inGO:0005769 early endosome MGI_ref:2667558; PMID:12724326
GO:0005886 plasma membrane MGI_ref:2667558; PMID:12724326
GO:0005903 brush border MGI_ref:3619154; PMID:11090085
GO:0005903 brush border MGI_ref:3619154; PMID:11090085
GO:0012505 endomembrane system MGI_ref:2667558; PMID:12724326