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Protein Ontology report - natural resistance-associated macrophage protein 2
PR:000002993 - http://purl.obolibrary.org/obo/PR_000002993
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002993   
  PRO namenatural resistance-associated macrophage protein 2 
  Synonyms
PRO-Short-label: EXACT:SLC11A2
Gene-based: RELATED:DCT1 | DMT1 | NRAMP2 | OK/SW-cl.20
Other: EXACT:divalent cation transporter 1 | divalent metal transporter 1 | DMT-1 | NRAMP 2 | solute carrier family 11 member 2
  Definition"An NRAMP-like divalent ion transporter that is a translation product of the human SLC11A2 gene or a 1:1 ortholog thereof." [PRO:HJD] 
  PRO Categorygene 
  ParentPR:000002992 NRAMP-like divalent ion transporter
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 16                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:967
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?
gene



PR:000002993 natural resistance-associated macrophage protein 2

SLC11A2


organism-gene



PR:B3F8C5 NRAMP2 isoform 1 (chicken)

chick-SLC11A2


organism-gene



PR:O54902 natural resistance-associated macrophage protein 2 (rat)

rSLC11A2


organism-sequence



PR:O54902-1 natural resistance-associated macrophage protein 2 isoform r2 (rat)

rSLC11A2/iso:r2


organism-sequence



PR:O54902-2 natural resistance-associated macrophage protein 2 isoform r1 (rat)

rSLC11A2/iso:r1


organism-gene



PR:P49281 natural resistance-associated macrophage protein 2 (human)

hSLC11A2


organism-sequence



PR:000063697 natural resistance-associated macrophage protein 2 sequence variant G212V (human)

hSLC11A2/var:G212V


organism-sequence



PR:000063872 natural resistance-associated macrophage protein 2 sequence variant R416C (human)

hSLC11A2/var:R416C


organism-sequence



PR:000064631 natural resistance-associated macrophage protein 2 sequence variant E399D (human)

hSLC11A2/var:E399D


organism-sequence



PR:P49281-1 natural resistance-associated macrophage protein 2 isoform 2 (human)

hSLC11A2/iso:2


organism-sequence



PR:P49281-2 natural resistance-associated macrophage protein 2 isoform 1 (human)

hSLC11A2/iso:1


organism-sequence



PR:P49281-3 natural resistance-associated macrophage protein 2 isoform h3 (human)

hSLC11A2/iso:h3


organism-sequence



PR:P49281-4 natural resistance-associated macrophage protein 2 isoform h4 (human)

hSLC11A2/iso:h4


organism-sequence



PR:P49281-5 natural resistance-associated macrophage protein 2 isoform h5 (human)

hSLC11A2/iso:h5


organism-modification



PR:000074463 natural resistance-associated macrophage protein 2 deaminated 1 (human)

hSLC11A2/Deam:1


organism-modification



PR:000076056 natural resistance-associated macrophage protein 2 deaminated 2 (human)

hSLC11A2/Deam:2


organism-modification



PR:000080800 natural resistance-associated macrophage protein 2 deaminated 3 (human)

hSLC11A2/Deam:3


organism-gene



PR:P49282 natural resistance-associated macrophage protein 2 (mouse)

mSLC11A2

Yes

organism-sequence



PR:P49282-1 natural resistance-associated macrophage protein 2 isoform 2 (mouse)

mSLC11A2/iso:2

Yes

organism-sequence



PR:P49282-2 natural resistance-associated macrophage protein 2 isoform 1 (mouse)

mSLC11A2/iso:1

Yes

organism-sequence



PR:P49282-3 natural resistance-associated macrophage protein 2 isoform m3 (mouse)

mSLC11A2/iso:m3


organism-sequence



PR:P49282-4 natural resistance-associated macrophage protein 2 isoform m4 (mouse)

mSLC11A2/iso:m4


organism-gene



PR:P49283 protein Malvolio (fruit fly)

fly-SLC11A2


organism-sequence



PR:P49283-1 protein Malvolio isoform C (fruit fly)

fly-SLC11A2/iso:C


organism-sequence



PR:P49283-2 protein Malvolio isoform A (fruit fly)

fly-SLC11A2/iso:A


organism-gene



PR:Q869V1 metal transporter nramp1 homolog (Dictyostelium discoideum)

Dicty-SLC11A2


sequence



PR:000002995 natural resistance-associated macrophage protein 2 isoform 1

SLC11A2/iso:1


organism-sequence



PR:P49281-2 natural resistance-associated macrophage protein 2 isoform 1 (human)

hSLC11A2/iso:1


organism-sequence



PR:P49282-2 natural resistance-associated macrophage protein 2 isoform 1 (mouse)

mSLC11A2/iso:1

Yes

sequence



PR:000002996 natural resistance-associated macrophage protein 2 isoform 2

SLC11A2/iso:2


organism-sequence



PR:P49281-1 natural resistance-associated macrophage protein 2 isoform 2 (human)

hSLC11A2/iso:2


organism-sequence



PR:P49282-1 natural resistance-associated macrophage protein 2 isoform 2 (mouse)

mSLC11A2/iso:2

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P49282 mSLC11A2 acts_upstream_of_or_withinGO:0006778 porphyrin-containing compound metabolic process PMID:4404581
GO:0006826 iron ion transport PMID:807277
GO:0007611 learning or memory PMID:19211831
GO:0048813 dendrite morphogenesis PMID:19211831
GO:0048821 erythrocyte development PMID:15849611
GO:0060586 multicellular organismal-level iron ion homeostasis PMID:5070129
PR:P49282-1 mSLC11A2/iso:2 acts_upstream_of_or_withinGO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006826 iron ion transport MGI_ref:3849744; PMID:10942769
GO:0006826 iron ion transport MGI_ref:3849744; PMID:10942769
GO:1902600 proton transmembrane transport MGI_ref:3037617; PMID:15024413
enablesGO:0015078 proton transmembrane transporter activity MGI_ref:3037617; PMID:15024413
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3849744; PMID:10942769
located_inGO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0009986 cell surface MGI_ref:3695635; PMID:17097837
GO:0055037 recycling endosome MGI_ref:3695780; PMID:16905747
GO:0055037 recycling endosome MGI_ref:3695780; PMID:16905747
PR:P49282-2 mSLC11A2/iso:1 acts_upstream_of_or_withinGO:0006824 cobalt ion transport MGI_ref:3603092; PMID:16142913
GO:0006826 iron ion transport MGI_ref:3603092; PMID:16142913
GO:0033212 iron import into cell MGI_ref:3037617; PMID:15024413
enablesGO:0005381 iron ion transmembrane transporter activity MGI_ref:3603092; PMID:16142913
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3603092; PMID:16142913
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3037617; PMID:15024413
located_inGO:0005769 early endosome MGI_ref:2667558; PMID:12724326
GO:0005886 plasma membrane MGI_ref:2667558; PMID:12724326
GO:0005903 brush border MGI_ref:3619154; PMID:11090085
GO:0005903 brush border MGI_ref:3619154; PMID:11090085
GO:0012505 endomembrane system MGI_ref:2667558; PMID:12724326