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Protein Ontology report - natural resistance-associated macrophage protein 2
PR:000002993 -
http://purl.obolibrary.org/obo/PR_000002993
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000002993
PRO name
natural resistance-associated macrophage protein 2
Synonyms
PRO-Short-label
:
EXACT:
SLC11A2
Gene-based
:
RELATED:
DCT1 | DMT1 | NRAMP2 | OK/SW-cl.20
Other
:
EXACT:
divalent cation transporter 1 | divalent metal transporter 1 | DMT-1 | NRAMP 2 | solute carrier family 11 member 2
Definition
"An NRAMP-like divalent ion transporter that is a translation product of the human SLC11A2 gene or a 1:1 ortholog thereof." [PRO:HJD]
PRO Category
gene
Parent
PR:000002992
NRAMP-like divalent ion transporter
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
6
Sequence
2
Organism-Sequence
16
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:967
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
gene
PR:000002993
natural resistance-associated macrophage protein 2
SLC11A2
organism-gene
PR:B3F8C5
NRAMP2 isoform 1 (chicken)
chick-SLC11A2
organism-gene
PR:O54902
natural resistance-associated macrophage protein 2 (rat)
rSLC11A2
organism-sequence
PR:O54902-1
natural resistance-associated macrophage protein 2 isoform r2 (rat)
rSLC11A2/iso:r2
organism-sequence
PR:O54902-2
natural resistance-associated macrophage protein 2 isoform r1 (rat)
rSLC11A2/iso:r1
organism-gene
PR:P49281
natural resistance-associated macrophage protein 2 (human)
hSLC11A2
organism-sequence
PR:000063697
natural resistance-associated macrophage protein 2 sequence variant G212V (human)
hSLC11A2/var:G212V
organism-sequence
PR:000063872
natural resistance-associated macrophage protein 2 sequence variant R416C (human)
hSLC11A2/var:R416C
organism-sequence
PR:000064631
natural resistance-associated macrophage protein 2 sequence variant E399D (human)
hSLC11A2/var:E399D
organism-sequence
PR:P49281-1
natural resistance-associated macrophage protein 2 isoform 2 (human)
hSLC11A2/iso:2
organism-sequence
PR:P49281-2
natural resistance-associated macrophage protein 2 isoform 1 (human)
hSLC11A2/iso:1
organism-sequence
PR:P49281-3
natural resistance-associated macrophage protein 2 isoform h3 (human)
hSLC11A2/iso:h3
organism-sequence
PR:P49281-4
natural resistance-associated macrophage protein 2 isoform h4 (human)
hSLC11A2/iso:h4
organism-sequence
PR:P49281-5
natural resistance-associated macrophage protein 2 isoform h5 (human)
hSLC11A2/iso:h5
organism-modification
PR:000074463
natural resistance-associated macrophage protein 2 deaminated 1 (human)
hSLC11A2/Deam:1
organism-modification
PR:000076056
natural resistance-associated macrophage protein 2 deaminated 2 (human)
hSLC11A2/Deam:2
organism-modification
PR:000080800
natural resistance-associated macrophage protein 2 deaminated 3 (human)
hSLC11A2/Deam:3
organism-gene
PR:P49282
natural resistance-associated macrophage protein 2 (mouse)
mSLC11A2
Yes
organism-sequence
PR:P49282-1
natural resistance-associated macrophage protein 2 isoform 2 (mouse)
mSLC11A2/iso:2
Yes
organism-sequence
PR:P49282-2
natural resistance-associated macrophage protein 2 isoform 1 (mouse)
mSLC11A2/iso:1
Yes
organism-sequence
PR:P49282-3
natural resistance-associated macrophage protein 2 isoform m3 (mouse)
mSLC11A2/iso:m3
organism-sequence
PR:P49282-4
natural resistance-associated macrophage protein 2 isoform m4 (mouse)
mSLC11A2/iso:m4
organism-gene
PR:P49283
protein Malvolio (fruit fly)
fly-SLC11A2
organism-sequence
PR:P49283-1
protein Malvolio isoform C (fruit fly)
fly-SLC11A2/iso:C
organism-sequence
PR:P49283-2
protein Malvolio isoform A (fruit fly)
fly-SLC11A2/iso:A
organism-gene
PR:Q869V1
metal transporter nramp1 homolog (Dictyostelium discoideum)
Dicty-SLC11A2
sequence
PR:000002995
natural resistance-associated macrophage protein 2 isoform 1
SLC11A2/iso:1
organism-sequence
PR:P49281-2
natural resistance-associated macrophage protein 2 isoform 1 (human)
hSLC11A2/iso:1
organism-sequence
PR:P49282-2
natural resistance-associated macrophage protein 2 isoform 1 (mouse)
mSLC11A2/iso:1
Yes
sequence
PR:000002996
natural resistance-associated macrophage protein 2 isoform 2
SLC11A2/iso:2
organism-sequence
PR:P49281-1
natural resistance-associated macrophage protein 2 isoform 2 (human)
hSLC11A2/iso:2
organism-sequence
PR:P49282-1
natural resistance-associated macrophage protein 2 isoform 2 (mouse)
mSLC11A2/iso:2
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:P49282
mSLC11A2
acts_upstream_of_or_within
GO:0006778
porphyrin-containing compound metabolic process
PMID:4404581
GO:0006826
iron ion transport
PMID:807277
GO:0007611
learning or memory
PMID:19211831
GO:0048813
dendrite morphogenesis
PMID:19211831
GO:0048821
erythrocyte development
PMID:15849611
GO:0060586
multicellular organismal-level iron ion homeostasis
PMID:5070129
PR:P49282-1
mSLC11A2/iso:2
acts_upstream_of_or_within
GO:0006824
cobalt ion transport
MGI_ref:3849744;
PMID:10942769
GO:0006824
cobalt ion transport
MGI_ref:3849744;
PMID:10942769
GO:0006824
cobalt ion transport
MGI_ref:3849744;
PMID:10942769
GO:0006826
iron ion transport
MGI_ref:3849744;
PMID:10942769
GO:0006826
iron ion transport
MGI_ref:3849744;
PMID:10942769
GO:1902600
proton transmembrane transport
MGI_ref:3037617;
PMID:15024413
enables
GO:0015078
proton transmembrane transporter activity
MGI_ref:3037617;
PMID:15024413
GO:0015087
cobalt ion transmembrane transporter activity
MGI_ref:3849744;
PMID:10942769
GO:0015087
cobalt ion transmembrane transporter activity
MGI_ref:3849744;
PMID:10942769
GO:0015093
ferrous iron transmembrane transporter activity
MGI_ref:3849744;
PMID:10942769
GO:0015093
ferrous iron transmembrane transporter activity
MGI_ref:3849744;
PMID:10942769
located_in
GO:0005886
plasma membrane
MGI_ref:3849744;
PMID:10942769
GO:0005886
plasma membrane
MGI_ref:3849744;
PMID:10942769
GO:0005886
plasma membrane
MGI_ref:3849744;
PMID:10942769
GO:0009986
cell surface
MGI_ref:3695635;
PMID:17097837
GO:0055037
recycling endosome
MGI_ref:3695780;
PMID:16905747
GO:0055037
recycling endosome
MGI_ref:3695780;
PMID:16905747
PR:P49282-2
mSLC11A2/iso:1
acts_upstream_of_or_within
GO:0006824
cobalt ion transport
MGI_ref:3603092;
PMID:16142913
GO:0006826
iron ion transport
MGI_ref:3603092;
PMID:16142913
GO:0033212
iron import into cell
MGI_ref:3037617;
PMID:15024413
enables
GO:0005381
iron ion transmembrane transporter activity
MGI_ref:3603092;
PMID:16142913
GO:0015087
cobalt ion transmembrane transporter activity
MGI_ref:3603092;
PMID:16142913
GO:0015093
ferrous iron transmembrane transporter activity
MGI_ref:3037617;
PMID:15024413
located_in
GO:0005769
early endosome
MGI_ref:2667558;
PMID:12724326
GO:0005886
plasma membrane
MGI_ref:2667558;
PMID:12724326
GO:0005903
brush border
MGI_ref:3619154;
PMID:11090085
GO:0005903
brush border
MGI_ref:3619154;
PMID:11090085
GO:0012505
endomembrane system
MGI_ref:2667558;
PMID:12724326
