back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - natural resistance-associated macrophage protein 2
PR:000002993 - http://purl.obolibrary.org/obo/PR_000002993
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002993   
  PRO namenatural resistance-associated macrophage protein 2 
  Synonyms
PRO-Short-label: EXACT:SLC11A2
Gene-based: RELATED:DCT1 | DMT1 | NRAMP2 | OK/SW-cl.20
Other: EXACT:divalent cation transporter 1 | divalent metal transporter 1 | DMT-1 | NRAMP 2 | solute carrier family 11 member 2
  Definition"An NRAMP-like divalent ion transporter that is a translation product of the human SLC11A2 gene or a 1:1 ortholog thereof." [PRO:HJD] 
  PRO Categorygene 
  ParentPR:000002992 NRAMP-like divalent ion transporter
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 16                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
IUPHARobj:967
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000002993

natural resistance-associated macrophage protein 2

SLC11A2


"An NRAMP-like divalent ion transporter that is a translation product of the human SLC11A2 gene or a 1:1 ortholog thereof." [PRO:HJD]


organism-gene



PR:B3F8C5

NRAMP2 isoform 1 (chicken)

chick-SLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of chicken." [PANTHER:PTHR11706:SF7, PRO:DNx]


organism-gene



PR:O54902

natural resistance-associated macrophage protein 2 (rat)

rSLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of rat." [OMA:O54902, PRO:DNx]


organism-sequence



PR:O54902-1

natural resistance-associated macrophage protein 2 isoform r2 (rat)

rSLC11A2/iso:r2


"A natural resistance-associated macrophage protein 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O54902-1." [PRO:DNx, UniProtKB:O54902]


organism-sequence



PR:O54902-2

natural resistance-associated macrophage protein 2 isoform r1 (rat)

rSLC11A2/iso:r1


"A natural resistance-associated macrophage protein 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O54902-2." [PRO:DNx, UniProtKB:O54902]


organism-gene



PR:P49281

natural resistance-associated macrophage protein 2 (human)

hSLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of human." [PRO:HJD, UniProtKB:P49281]


organism-sequence



PR:000063697

natural resistance-associated macrophage protein 2 sequence variant G212V (human)

hSLC11A2/var:G212V


"A natural resistance-associated macrophage protein 2 (human) that has a Val residue at the position equivalent to Gly-212 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Gly-212, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-5623771]


organism-sequence



PR:000063872

natural resistance-associated macrophage protein 2 sequence variant R416C (human)

hSLC11A2/var:R416C


"A natural resistance-associated macrophage protein 2 (human) that has a Cys residue at the position equivalent to Arg-416 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Arg-416, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-5623758]


organism-sequence



PR:000064631

natural resistance-associated macrophage protein 2 sequence variant E399D (human)

hSLC11A2/var:E399D


"A natural resistance-associated macrophage protein 2 (human) that has an Asp residue at the position equivalent to Glu-399 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Glu-399, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-5623732]


organism-sequence



PR:P49281-1

natural resistance-associated macrophage protein 2 isoform 2 (human)

hSLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 isoform 2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49281-2

natural resistance-associated macrophage protein 2 isoform 1 (human)

hSLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49281-3

natural resistance-associated macrophage protein 2 isoform h3 (human)

hSLC11A2/iso:h3


"A natural resistance-associated macrophage protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49281-3." [PRO:DNx, UniProtKB:P49281]


organism-sequence



PR:P49281-4

natural resistance-associated macrophage protein 2 isoform h4 (human)

hSLC11A2/iso:h4


"A natural resistance-associated macrophage protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49281-4." [PRO:DNx, UniProtKB:P49281]


organism-sequence



PR:P49281-5

natural resistance-associated macrophage protein 2 isoform h5 (human)

hSLC11A2/iso:h5


"A natural resistance-associated macrophage protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49281-5." [PRO:DNx, UniProtKB:P49281]


organism-modification



PR:000074463

natural resistance-associated macrophage protein 2 deaminated 1 (human)

hSLC11A2/Deam:1


"A natural resistance-associated macrophage protein 2 (human) that has been deaminated on the residue at the position equivalent to Asn-443 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Asn-443, MOD:00684." [IEDB_epitope:1331246, PRO:DNx]


organism-modification



PR:000076056

natural resistance-associated macrophage protein 2 deaminated 2 (human)

hSLC11A2/Deam:2


"A natural resistance-associated macrophage protein 2 (human) that has been deaminated on the residue at the position equivalent to Gln-395 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Gln-395, MOD:00685." [IEDB_epitope:1586697, PRO:DNx]


organism-modification



PR:000080800

natural resistance-associated macrophage protein 2 deaminated 3 (human)

hSLC11A2/Deam:3


"A natural resistance-associated macrophage protein 2 (human) that has been deaminated on the residue at the position equivalent to Asn-311 of the amino acid sequence represented by UniProtKB:P49281-1. Example: UniProtKB:P49281-1, Asn-311, MOD:00684." [IEDB_epitope:1986448, PRO:DNx]


organism-gene



PR:P49282

natural resistance-associated macrophage protein 2 (mouse)

mSLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of mouse." [OMA:P49282, PRO:DNx]

Yes

organism-sequence



PR:P49282-1

natural resistance-associated macrophage protein 2 isoform 2 (mouse)

mSLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-sequence



PR:P49282-2

natural resistance-associated macrophage protein 2 isoform 1 (mouse)

mSLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-sequence



PR:P49282-3

natural resistance-associated macrophage protein 2 isoform m3 (mouse)

mSLC11A2/iso:m3


"A natural resistance-associated macrophage protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-3." [PRO:DNx, UniProtKB:P49282]


organism-sequence



PR:P49282-4

natural resistance-associated macrophage protein 2 isoform m4 (mouse)

mSLC11A2/iso:m4


"A natural resistance-associated macrophage protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-4." [PRO:DNx, UniProtKB:P49282]


organism-gene



PR:P49283

protein Malvolio (fruit fly)

fly-SLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of fruit fly." [OMA:P49283, PRO:DNx]


organism-sequence



PR:P49283-1

protein Malvolio isoform C (fruit fly)

fly-SLC11A2/iso:C


"A protein Malvolio (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49283-1." [PRO:DNx, UniProtKB:P49283]


organism-sequence



PR:P49283-2

protein Malvolio isoform A (fruit fly)

fly-SLC11A2/iso:A


"A protein Malvolio (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49283-2." [PRO:DNx, UniProtKB:P49283]


organism-gene



PR:Q869V1

metal transporter nramp1 homolog (Dictyostelium discoideum)

Dicty-SLC11A2


"A natural resistance-associated macrophage protein 2 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q869V1, PRO:DNx]


sequence



PR:000002995

natural resistance-associated macrophage protein 2 isoform 1

SLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-2 or a 1:1 ortholog thereof." [PMID:7789986, PRO:HJD]


organism-sequence



PR:P49281-2

natural resistance-associated macrophage protein 2 isoform 1 (human)

hSLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49282-2

natural resistance-associated macrophage protein 2 isoform 1 (mouse)

mSLC11A2/iso:1


"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

sequence



PR:000002996

natural resistance-associated macrophage protein 2 isoform 2

SLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-1 or a 1:1 ortholog thereof." [PRO:HJD]


organism-sequence



PR:P49281-1

natural resistance-associated macrophage protein 2 isoform 2 (human)

hSLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 isoform 2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49282-1

natural resistance-associated macrophage protein 2 isoform 2 (mouse)

mSLC11A2/iso:2


"A natural resistance-associated macrophage protein 2 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]

Yes

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P49282 mSLC11A2 acts_upstream_of_or_withinGO:0006778 porphyrin-containing compound metabolic process PMID:4404581
GO:0006826 iron ion transport PMID:807277
GO:0007611 learning or memory PMID:19211831
GO:0048813 dendrite morphogenesis PMID:19211831
GO:0048821 erythrocyte development PMID:15849611
GO:0060586 multicellular organismal-level iron ion homeostasis PMID:5070129
PR:P49282-1 mSLC11A2/iso:2 acts_upstream_of_or_withinGO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006824 cobalt ion transport MGI_ref:3849744; PMID:10942769
GO:0006826 iron ion transport MGI_ref:3849744; PMID:10942769
GO:0006826 iron ion transport MGI_ref:3849744; PMID:10942769
GO:1902600 proton transmembrane transport MGI_ref:3037617; PMID:15024413
enablesGO:0015078 proton transmembrane transporter activity MGI_ref:3037617; PMID:15024413
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3849744; PMID:10942769
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3849744; PMID:10942769
located_inGO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0005886 plasma membrane MGI_ref:3849744; PMID:10942769
GO:0009986 cell surface MGI_ref:3695635; PMID:17097837
GO:0055037 recycling endosome MGI_ref:3695780; PMID:16905747
GO:0055037 recycling endosome MGI_ref:3695780; PMID:16905747
PR:P49282-2 mSLC11A2/iso:1 acts_upstream_of_or_withinGO:0006824 cobalt ion transport MGI_ref:3603092; PMID:16142913
GO:0006826 iron ion transport MGI_ref:3603092; PMID:16142913
GO:0033212 iron import into cell MGI_ref:3037617; PMID:15024413
enablesGO:0005381 iron ion transmembrane transporter activity MGI_ref:3603092; PMID:16142913
GO:0015087 cobalt ion transmembrane transporter activity MGI_ref:3603092; PMID:16142913
GO:0015093 ferrous iron transmembrane transporter activity MGI_ref:3037617; PMID:15024413
located_inGO:0005769 early endosome MGI_ref:2667558; PMID:12724326
GO:0005886 plasma membrane MGI_ref:2667558; PMID:12724326
GO:0005903 brush border MGI_ref:3619154; PMID:11090085
GO:0005903 brush border MGI_ref:3619154; PMID:11090085
GO:0012505 endomembrane system MGI_ref:2667558; PMID:12724326