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Protein Ontology report - natural resistance-associated macrophage protein 2 isoform 1
PR:000002995 - http://purl.obolibrary.org/obo/PR_000002995
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002995   
  PRO namenatural resistance-associated macrophage protein 2 isoform 1 
  Synonyms
PRO-Short-label: EXACT:SLC11A2/iso:1
Other: EXACT:IRE
  Definition"A natural resistance-associated macrophage protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-2 or a 1:1 ortholog thereof." [PMID:7789986, PRO:HJD] 
  PRO Categorysequence 
  ParentPR:000002993 natural resistance-associated macrophage protein 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
sequence


PR:000002995
natural resistance-associated macrophage protein 2 isoform 1
SLC11A2/iso:1
"A natural resistance-associated macrophage protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49282-2 or a 1:1 ortholog thereof." [PMID:7789986, PRO:HJD]

organism-sequence


PR:P49281-2
natural resistance-associated macrophage protein 2 isoform 1 (human)
hSLC11A2/iso:1
"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of human." [PRO:HJD]

organism-sequence


PR:P49282-2
natural resistance-associated macrophage protein 2 isoform 1 (mouse)
mSLC11A2/iso:1
"A natural resistance-associated macrophage protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006824 cobalt ion transportPR:P49282-2 mSLC11A2/iso:1 MGI_ref:3603092; PMID:16142913
GO:0006826 iron ion transportPR:P49282-2 mSLC11A2/iso:1 MGI_ref:3603092; PMID:16142913
GO:0033212 iron import into cellPR:P49282-2 mSLC11A2/iso:1 MGI_ref:3037617; PMID:15024413

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005381 iron ion transmembrane transporter activityPR:P49282-2 mSLC11A2/iso:1 MGI_ref:3603092; PMID:16142913
GO:0015087 cobalt ion transmembrane transporter activityPR:P49282-2 mSLC11A2/iso:1 MGI_ref:3603092; PMID:16142913
GO:0015093 ferrous iron transmembrane transporter activityPR:P49282-2 mSLC11A2/iso:1 MGI_ref:3037617; PMID:15024413

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005769 early endosomePR:P49282-2 mSLC11A2/iso:1 MGI_ref:2667558; PMID:12724326
GO:0005886 plasma membranePR:P49282-2 mSLC11A2/iso:1 MGI_ref:2667558; PMID:12724326
GO:0005903 brush borderPR:P49282-2 mSLC11A2/iso:1 MGI_ref:3619154; PMID:11090085
PR:P49282-2 mSLC11A2/iso:1 MGI_ref:3619154; PMID:11090085
GO:0012505 endomembrane systemPR:P49282-2 mSLC11A2/iso:1 MGI_ref:2667558; PMID:12724326