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Protein Ontology report - focal adhesion kinase 2
PR:000003032 - http://purl.obolibrary.org/obo/PR_000003032
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003032   
  PRO namefocal adhesion kinase 2 
  Synonyms
PRO-Short-label: EXACT:PTK2B
Gene-based: RELATED:FAK2 | PYK2 | RAFTK
Other: EXACT:CADTK | CAK-beta | CAKB | calcium-dependent tyrosine kinase | calcium-regulated non-receptor proline-rich tyrosine kinase | cell adhesion kinase beta | FADK 2 | proline-rich tyrosine kinase 2 | related adhesion focal tyrosine kinase
  Definition"A focal adhesion kinase that is a translation product of the human PTK2B gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000003030 focal adhesion kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 5                                        
         Modification2                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2181
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
gene


PR:000003032
focal adhesion kinase 2
PTK2B
"A focal adhesion kinase that is a translation product of the human PTK2B gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P70600
protein-tyrosine kinase 2-beta (rat)
rPTK2B
"A focal adhesion kinase 2 that is encoded in the genome of rat." [OMA:P70600, PRO:DNx]

organism-sequence


PR:P70600-1
protein-tyrosine kinase 2-beta isoform r1 (rat)
rPTK2B/iso:r1
"A protein-tyrosine kinase 2-beta (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70600-1." [PRO:DNx, UniProtKB:P70600]

organism-sequence


PR:P70600-2
protein-tyrosine kinase 2-beta isoform r2 (rat)
rPTK2B/iso:r2
"A protein-tyrosine kinase 2-beta (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70600-2." [PRO:DNx, UniProtKB:P70600]

organism-sequence


PR:P70600-3
protein-tyrosine kinase 2-beta isoform 3 (rat)
rPTK2B/iso:3
"A focal adhesion kinase 2 isoform 2 that is encoded in the genome of rat." [PRO:DNx]

organism-gene


PR:Q14289
protein-tyrosine kinase 2-beta (human)
hPTK2B
"A focal adhesion kinase 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q14289]

organism-sequence


PR:Q14289-1
protein-tyrosine kinase 2-beta isoform 1 (human)
hPTK2B/iso:1
"A focal adhesion kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036642
focal adhesion kinase 2 isoform 1 phosphorylated 1 (human)
hPTK2B/iso:1/Phos:1
"A focal adhesion kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048." [PMID:11698270, PRO:CL]
Yes
organism-sequence


PR:Q14289-2
protein-tyrosine kinase 2-beta isoform 2 (human)
hPTK2B/iso:2
"A focal adhesion kinase 2 isoform 2 that is encoded in the genome of human." [PRO:DNx]

organism-modification


PR:000048954
protein-tyrosine kinase 2-beta phosphotyrosine form (human)
hPTK2B/PhosTyr+
"A protein-tyrosine kinase 2-beta (human) that includes at least one phosphorylated tyrosine. UniProtKB:Q14289, MOD:00048." [PRO:DNx, Reactome:R-HSA-508515]

organism-modification


PR:000036642
focal adhesion kinase 2 isoform 1 phosphorylated 1 (human)
hPTK2B/iso:1/Phos:1
"A focal adhesion kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048." [PMID:11698270, PRO:CL]
Yes
organism-modification


PR:000048953
protein-tyrosine kinase 2-beta phosphorylated 2 (human)
hPTK2B/Phos:2
"A protein-tyrosine kinase 2-beta (human) that has been phosphorylated on the residue at the position equivalent to Tyr-402 of the amino acid sequence represented by UniProtKB:Q14289. UniProtKB:Q14289, Tyr-402, MOD:00048." [PRO:DNx, Reactome:R-HSA-5218721]

organism-modification


PR:000065247
protein-tyrosine kinase 2-beta methylated 1 (human)
hPTK2B/Me:1
"A protein-tyrosine kinase 2-beta (human) that has been methylated on the residue at the position equivalent to Cys-246 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Cys-246, MOD:00660." [IEDB_epitope:1002474, PRO:DNx]

organism-modification


PR:000070234
protein-tyrosine kinase 2-beta cysteinylated 1 (human)
hPTK2B/Cyst:1
"A protein-tyrosine kinase 2-beta (human) that has been cysteinylated on the residue at the position equivalent to Cys-246 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Cys-246, MOD:00765." [IEDB_epitope:1587468, PRO:DNx]

organism-modification


PR:000071896
protein-tyrosine kinase 2-beta deaminated 1 (human)
hPTK2B/Deam:1
"A protein-tyrosine kinase 2-beta (human) that has been deaminated on the residue at the position equivalent to Gln-329 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Gln-329, MOD:00685." [IEDB_epitope:1349689, PRO:DNx]

organism-modification


PR:000077476
protein-tyrosine kinase 2-beta deaminated 2 (human)
hPTK2B/Deam:2
"A protein-tyrosine kinase 2-beta (human) that has been deaminated on the residue at the position equivalent to Asn-193 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Asn-193, MOD:00684." [IEDB_epitope:635229, PRO:DNx]

organism-modification


PR:000078700
protein-tyrosine kinase 2-beta methylated 2 (human)
hPTK2B/Me:2
"A protein-tyrosine kinase 2-beta (human) that has been methylated on the residue at the position equivalent to Cys-534 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Cys-534, MOD:00660." [IEDB_epitope:1058353, PRO:DNx]

organism-modification


PR:000079503
protein-tyrosine kinase 2-beta methylated 3 (human)
hPTK2B/Me:3
"A protein-tyrosine kinase 2-beta (human) that has been methylated on the residue at the position equivalent to Cys-120 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Cys-120, MOD:00660." [IEDB_epitope:1010336, IEDB_epitope:1015039, PRO:DNx]

organism-modification


PR:000081549
protein-tyrosine kinase 2-beta methylated 4 (human)
hPTK2B/Me:4
"A protein-tyrosine kinase 2-beta (human) that has been methylated on the residue at the position equivalent to Cys-298 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Cys-298, MOD:00660." [IEDB_epitope:1051088, PRO:DNx]

organism-modification


PR:000083633
protein-tyrosine kinase 2-beta cysteinylated 2 (human)
hPTK2B/Cyst:2
"A protein-tyrosine kinase 2-beta (human) that has been cysteinylated on the residue at the position equivalent to Cys-534 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Cys-534, MOD:00765." [IEDB_epitope:1031252, IEDB_epitope:638607, PRO:DNx]

organism-modification


PR:000083918
protein-tyrosine kinase 2-beta phosphorylated 1 (human)
hPTK2B/Phos:1
"A protein-tyrosine kinase 2-beta (human) that has been phosphorylated on the residue at the position equivalent to Ser-530 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Ser-530, MOD:00046." [IEDB_epitope:1374869, PRO:DNx]

organism-modification


PR:000085313
protein-tyrosine kinase 2-beta methylated 5 (human)
hPTK2B/Me:5
"A protein-tyrosine kinase 2-beta (human) that has been methylated on the residue at the position equivalent to Cys-310 of the amino acid sequence represented by UniProtKB:Q14289-1. Example: UniProtKB:Q14289-1, Cys-310, MOD:00660." [IEDB_epitope:1026113, PRO:DNx]

organism-gene


PR:Q9QVP9
protein-tyrosine kinase 2-beta (mouse)
mPTK2B
"A focal adhesion kinase 2 that is encoded in the genome of mouse." [OMA:Q9QVP9, PRO:DNx]

organism-modification


PR:000079444
protein-tyrosine kinase 2-beta cysteinylated 1 (mouse)
mPTK2B/Cyst:1
"A protein-tyrosine kinase 2-beta (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-545 of the amino acid sequence represented by UniProtKB:Q9QVP9. UniProtKB:Q9QVP9, Cys-545, MOD:00765." [IEDB_epitope:2089144, IEDB_epitope:2115153, PRO:DNx]

sequence


PR:000003239
focal adhesion kinase 2 isoform 1
PTK2B/iso:1
"A focal adhesion kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14289-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:Q14289-1
protein-tyrosine kinase 2-beta isoform 1 (human)
hPTK2B/iso:1
"A focal adhesion kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036642
focal adhesion kinase 2 isoform 1 phosphorylated 1 (human)
hPTK2B/iso:1/Phos:1
"A focal adhesion kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048." [PMID:11698270, PRO:CL]
Yes
modification


PR:000003241
focal adhesion kinase 2 isoform 1 phosphorylated form
PTK2B/iso:1/PhosRes+
"A focal adhesion kinase 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003242
focal adhesion kinase 2 isoform 1 phosphorylated 1
PTK2B/iso:1/Phos:1
"A focal adhesion kinase 2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residues that yield the active kinase. Example: UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048." [PMID:11698270, PRO:CL]

organism-modification


PR:000036642
focal adhesion kinase 2 isoform 1 phosphorylated 1 (human)
hPTK2B/iso:1/Phos:1
"A focal adhesion kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048." [PMID:11698270, PRO:CL]
Yes
sequence


PR:000040522
focal adhesion kinase 2 isoform 2
PTK2B/iso:2
"A focal adhesion kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14289-2 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:P70600-3
protein-tyrosine kinase 2-beta isoform 3 (rat)
rPTK2B/iso:3
"A focal adhesion kinase 2 isoform 2 that is encoded in the genome of rat." [PRO:DNx]

organism-sequence


PR:Q14289-2
protein-tyrosine kinase 2-beta isoform 2 (human)
hPTK2B/iso:2
"A focal adhesion kinase 2 isoform 2 that is encoded in the genome of human." [PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036642 hPTK2B/iso:1/Phos:1
UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048		 acts_upstream_of_or_withinGO:0070098 chemokine-mediated signaling pathway PMID:11698270