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Protein Ontology report - serine/threonine-protein kinase mTOR
PR:000003041 - http://purl.obolibrary.org/obo/PR_000003041
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003041   
  PRO nameserine/threonine-protein kinase mTOR 
  Synonyms
PRO-Short-label: EXACT:MTOR
Gene-based: RELATED:FRAP | FRAP1 | FRAP2 | RAFT1 | RAPT1
Other: EXACT:FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | mammalian target of rapamycin | mechanistic target of rapamycin | mTOR | rapamycin target protein 1
  Definition"A protein that is a translation product of the human MTOR gene or a 1:1 ortholog thereof." [PRO:CL] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 7                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2109
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000003041

serine/threonine-protein kinase mTOR

MTOR


"A protein that is a translation product of the human MTOR gene or a 1:1 ortholog thereof." [PRO:CL]


organism-gene



PR:P42345

serine/threonine-protein kinase mTOR (human)

hMTOR


"A serine/threonine-protein kinase mTOR that is encoded in the genome of human." [PRO:CL, UniProtKB:P42345]

Yes

organism-sequence



PR:P42345-1

serine/threonine-protein kinase mTOR isoform 1 (human)

hMTOR/iso:1


"A serine/threonine-protein kinase mTOR isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000045781

serine/threonine-protein kinase mTOR phosphorylated 1 (human)

hMTOR/Phos:1


"A serine/threonine-protein kinase mTOR (human) that has been phosphorylated at Ser-2481. UniProtKB:P42345, Ser-2481, MOD:00046." [iPTMnet:P42345, PMID:10702316]


organism-modification



PR:000068288

serine/threonine-protein kinase mTOR deaminated 1 (human)

hMTOR/Deam:1


"A serine/threonine-protein kinase mTOR (human) that has been deaminated on the residue at the position equivalent to Asn-2093 of the amino acid sequence represented by UniProtKB:P42345. UniProtKB:P42345, Asn-2093, MOD:00684." [IEDB_epitope:1333035, PRO:DNx]


organism-modification



PR:000073464

serine/threonine-protein kinase mTOR deaminated 2 (human)

hMTOR/Deam:2


"A serine/threonine-protein kinase mTOR (human) that has been deaminated on the residue at the position equivalent to Gln-2194 of the amino acid sequence represented by UniProtKB:P42345. UniProtKB:P42345, Gln-2194, MOD:00685." [IEDB_epitope:1564748, PRO:DNx]


organism-modification



PR:000081494

serine/threonine-protein kinase mTOR cysteinylated 1 (human)

hMTOR/Cyst:1


"A serine/threonine-protein kinase mTOR (human) that has been cysteinylated on the residue at the position equivalent to Cys-485 of the amino acid sequence represented by UniProtKB:P42345. UniProtKB:P42345, Cys-485, MOD:00765." [IEDB_epitope:1004671, PRO:DNx]


organism-gene



PR:P42346

serine/threonine-protein kinase mTOR (rat)

rMTOR


"A serine/threonine-protein kinase mTOR that is encoded in the genome of rat." [OMA:P42346, PRO:DNx]


organism-sequence



PR:P42346-1

serine/threonine-protein kinase mTOR isoform 1 (rat)

rMTOR/iso:1


"A serine/threonine-protein kinase mTOR isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q86C65

serine/threonine-protein kinase tor (Dictyostelium discoideum)

Dicty-MTOR


"A serine/threonine-protein kinase mTOR that is encoded in the genome of Dictyostelium discoideum." [OMA:Q86C65, PRO:DNx]


organism-gene



PR:Q95Q95

target of rapamycin homolog (worm)

MTOR (worm)


"A serine/threonine-protein kinase mTOR that is encoded in the genome of worm." [OMA:Q95Q95, PRO:DNx]


organism-sequence



PR:Q95Q95-1

target of rapamycin homolog isoform a (worm)

MTOR/iso:a (worm)


"A target of rapamycin homolog (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95Q95-1." [PRO:DNx, UniProtKB:Q95Q95]


organism-sequence



PR:Q95Q95-2

target of rapamycin homolog isoform b (worm)

MTOR/iso:b (worm)


"A target of rapamycin homolog (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95Q95-2." [PRO:DNx, UniProtKB:Q95Q95]


organism-gene



PR:Q9FR53

serine/threonine-protein kinase TOR (Arabidopsis thaliana)

At-MTOR


"A serine/threonine-protein kinase mTOR that is encoded in the genome of Arabidopsis thaliana." [OMA:Q9FR53, PRO:DNx]


organism-sequence



PR:Q9FR53-1

serine/threonine-protein kinase TOR isoform 1 (Arabidopsis thaliana)

At-MTOR/iso:1


"A serine/threonine-protein kinase TOR (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9FR53-1." [PRO:DNx, UniProtKB:Q9FR53]


organism-gene



PR:Q9JLN9

serine/threonine-protein kinase mTOR (mouse)

mMTOR


"A serine/threonine-protein kinase mTOR that is encoded in the genome of mouse." [OMA:Q9JLN9, PRO:DNx]


organism-sequence



PR:Q9JLN9-1

serine/threonine-protein kinase mTOR isoform 1 (mouse)

mMTOR/iso:1


"A serine/threonine-protein kinase mTOR isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000050320

serine/threonine-protein kinase mTOR isoform 1 phosphorylated 1 (mouse)

mMTOR/iso:1/Phos:1


"A serine/threonine-protein kinase mTOR isoform 1 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-2448 of the amino acid sequence represented by UniProtKB:Q9JLN9-1. UniProtKB:Q9JLN9-1, Ser-2448, MOD:00046." [PMID:10567225, PRO:LN]


organism-modification



PR:000050321

serine/threonine-protein kinase mTOR isoform 1 unphosphorylated 1 (mouse)

mMTOR/iso:1/UnPhos:1


"A serine/threonine-protein kinase mTOR isoform 1 (mouse) that lacks phosphorylation at at position equivalent to Ser-2448 of the amino acid sequence represented by UniProtKB:Q9JLN9-1. UniProtKB:Q9JLN9-1, Ser-2448, PR:000026291." [PMID:10567225, PRO:LN]


organism-sequence



PR:Q9JLN9-2

serine/threonine-protein kinase mTOR isoform m2 (mouse)

mMTOR/iso:m2


"A serine/threonine-protein kinase mTOR (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JLN9-2." [PRO:DNx, UniProtKB:Q9JLN9]


organism-gene



PR:Q9VK45

serine/threonine-protein kinase mTor (fruit fly)

fly-MTOR


"A serine/threonine-protein kinase mTOR that is encoded in the genome of fruit fly." [OMA:Q9VK45, PRO:DNx]


sequence



PR:000039438

serine/threonine-protein kinase mTOR isoform 1

MTOR/iso:1


"A serine/threonine-protein kinase mTOR that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42345-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P42345-1

serine/threonine-protein kinase mTOR isoform 1 (human)

hMTOR/iso:1


"A serine/threonine-protein kinase mTOR isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P42346-1

serine/threonine-protein kinase mTOR isoform 1 (rat)

rMTOR/iso:1


"A serine/threonine-protein kinase mTOR isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9JLN9-1

serine/threonine-protein kinase mTOR isoform 1 (mouse)

mMTOR/iso:1


"A serine/threonine-protein kinase mTOR isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000050320

serine/threonine-protein kinase mTOR isoform 1 phosphorylated 1 (mouse)

mMTOR/iso:1/Phos:1


"A serine/threonine-protein kinase mTOR isoform 1 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-2448 of the amino acid sequence represented by UniProtKB:Q9JLN9-1. UniProtKB:Q9JLN9-1, Ser-2448, MOD:00046." [PMID:10567225, PRO:LN]


organism-modification



PR:000050321

serine/threonine-protein kinase mTOR isoform 1 unphosphorylated 1 (mouse)

mMTOR/iso:1/UnPhos:1


"A serine/threonine-protein kinase mTOR isoform 1 (mouse) that lacks phosphorylation at at position equivalent to Ser-2448 of the amino acid sequence represented by UniProtKB:Q9JLN9-1. UniProtKB:Q9JLN9-1, Ser-2448, PR:000026291." [PMID:10567225, PRO:LN]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P42345 hMTOR acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:11602639
enablesGO:0005515 protein binding with PR:000035446 hTP53/iso:1/Phos:1 PMID:11602639
located_inGO:0005634 nucleus PMID:11602639