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Protein Ontology report - tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1
PR:000003068 - http://purl.obolibrary.org/obo/PR_000003068
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003068   
  PRO nametyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 
  Synonyms
PRO-Short-label: EXACT:ZAP70/iso:1/Phos:1
Other: EXACT:ZAP-70 activated | ZAP-70 active form
  Definition"A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form in which the phosphorylation occurs on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck, following TCR engagement. Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. It has been shown that Tyr-319 in the human sequence is required for the positive regulation of ZAP-70 function." [PMID:10037717, PRO:CL] 
  PRO Categorymodification 
  ParentPR:000003067 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?
modification



PR:000003068 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1

ZAP70/iso:1/Phos:1


organism-modification



PR:000036629 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human)

hZAP70/iso:1/Phos:1

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036629 hZAP70/iso:1/Phos:1 acts_upstream_of_or_withinGO:0090630 activation of GTPase activity PMID:9269777