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Protein Ontology report - signal transducer and activator of transcription 1 isoform 1
PR:000003073 - http://purl.obolibrary.org/obo/PR_000003073
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003073   
  PRO namesignal transducer and activator of transcription 1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:STAT1/iso:1
Other: EXACT:STAT1 alpha
RELATED:STAT1 p91
  Definition"A signal transducer and activator of transcription 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42224-1 or a 1:1 ortholog thereof." [PMID:1502203, PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000002087 signal transducer and activator of transcription 1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
sequence



PR:000003073

signal transducer and activator of transcription 1 isoform 1

STAT1/iso:1


"A signal transducer and activator of transcription 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42224-1 or a 1:1 ortholog thereof." [PMID:1502203, PRO:CNA]


organism-sequence



PR:P42224-1

signal transducer and activator of transcription 1 isoform 1 (human)

hSTAT1/iso:1


"A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026858

signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 (human)

hSTAT1/iso:1/Phos:1


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 in human. UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7657660, PRO:CNA, Reactome:R-HSA-873791, Reactome:R-HSA-909684]


organism-modification



PR:000027889

signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)

hSTAT1/iso:1/Phos:3


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 in human. UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]

Yes

organism-modification



PR:000027891

signal transducer and activator of transcription 1 isoform 1 sumoylated 1 (human)

hSTAT1/iso:1/Sumo:1


"A signal transducer and activator of transcription 1 isoform 1 sumoylated 1 in human. UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]


organism-modification



PR:000028637

signal transducer and activator of transcription 1 isoform 1 acetylated 1 (human)

hSTAT1/iso:1/Ac:1


"A signal transducer and activator of transcription 1 isoform 1 acetylated 1 in human. UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]


organism-modification



PR:000061402

signal transducer and activator of transcription 1 isoform 1 phosphorylated 2 (human)

hSTAT1/iso:1/Phos:2


"A signal transducer and activator of transcription 1 isoform 1 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. UniProtKB:P42224-1, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-873792, Reactome:R-HSA-909563]


organism-sequence



PR:P42225-1

signal transducer and activator of transcription 1 isoform 1 (mouse)

mSTAT1/iso:1


"A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000003075

signal transducer and activator of transcription 1 isoform 1 phosphorylated form

STAT1/iso:1/PhosRes+


"A signal transducer and activator of transcription 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003076

signal transducer and activator of transcription 1 isoform 1 phosphorylated 1

STAT1/iso:1/Phos:1


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the conserved GYI sequence following the SH2 domain. Example: UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7543024, PRO:CNA]


organism-modification



PR:000026858

signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 (human)

hSTAT1/iso:1/Phos:1


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 in human. UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7657660, PRO:CNA, Reactome:R-HSA-873791, Reactome:R-HSA-909684]


modification



PR:000027888

signal transducer and activator of transcription 1 isoform 1 phosphorylated 3

STAT1/iso:1/Phos:3


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated form that has been modified on a Ser residue located in the conserved PMSP sequence at the C-terminal transactivation domain. Example: UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]


organism-modification



PR:000027889

signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)

hSTAT1/iso:1/Phos:3


"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 in human. UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]

Yes

organism-modification



PR:000061402

signal transducer and activator of transcription 1 isoform 1 phosphorylated 2 (human)

hSTAT1/iso:1/Phos:2


"A signal transducer and activator of transcription 1 isoform 1 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. UniProtKB:P42224-1, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-873792, Reactome:R-HSA-909563]


modification



PR:000027890

signal transducer and activator of transcription 1 isoform 1 sumoylated 1

STAT1/iso:1/Sumo:1


"A signal transducer and activator of transcription 1 isoform 1 that has been modified on a Lys residue located right after the conserved GYI sequence in the C-terminal region. PIAS proteins promote this modification in response to IFN-gamma signaling. Example: UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]


organism-modification



PR:000027891

signal transducer and activator of transcription 1 isoform 1 sumoylated 1 (human)

hSTAT1/iso:1/Sumo:1


"A signal transducer and activator of transcription 1 isoform 1 sumoylated 1 in human. UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]


modification



PR:000028636

signal transducer and activator of transcription 1 isoform 1 acetylated 1

STAT1/iso:1/Ac:1


"A signal transducer and activator of transcription 1 isoform 1 that has been acetylated on Lys residues within the DNA binding domain. Example: UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]


organism-modification



PR:000028637

signal transducer and activator of transcription 1 isoform 1 acetylated 1 (human)

hSTAT1/iso:1/Ac:1


"A signal transducer and activator of transcription 1 isoform 1 acetylated 1 in human. UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0043065 positive regulation of apoptotic processPR:000027889 hSTAT1/iso:1/Phos:3 PMID:15322115

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005634 nucleusPR:000027889 hSTAT1/iso:1/Phos:3 PMID:15322115