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Protein Ontology report - signal transducer and activator of transcription 1 isoform 1
PR:000003073 - http://purl.obolibrary.org/obo/PR_000003073
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003073   
  PRO namesignal transducer and activator of transcription 1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:STAT1/iso:1
Other: EXACT:STAT1 alpha
RELATED:STAT1 p91
  Definition"A signal transducer and activator of transcription 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42224-1 or a 1:1 ortholog thereof." [PMID:1502203, PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000002087 signal transducer and activator of transcription 1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
sequence


PR:000003073
signal transducer and activator of transcription 1 isoform 1
STAT1/iso:1
"A signal transducer and activator of transcription 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42224-1 or a 1:1 ortholog thereof." [PMID:1502203, PRO:CNA]

organism-sequence


PR:P42224-1
signal transducer and activator of transcription 1 isoform 1 (human)
hSTAT1/iso:1
"A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000026858
signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 (human)
hSTAT1/iso:1/Phos:1
"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 in human. UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7657660, PRO:CNA, Reactome:R-HSA-873791, Reactome:R-HSA-909684]

organism-modification


PR:000027889
signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)
hSTAT1/iso:1/Phos:3
"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 in human. UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]
Yes
organism-modification


PR:000027891
signal transducer and activator of transcription 1 isoform 1 sumoylated 1 (human)
hSTAT1/iso:1/Sumo:1
"A signal transducer and activator of transcription 1 isoform 1 sumoylated 1 in human. UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]

organism-modification


PR:000028637
signal transducer and activator of transcription 1 isoform 1 acetylated 1 (human)
hSTAT1/iso:1/Ac:1
"A signal transducer and activator of transcription 1 isoform 1 acetylated 1 in human. UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]

organism-modification


PR:000061402
signal transducer and activator of transcription 1 isoform 1 phosphorylated 2 (human)
hSTAT1/iso:1/Phos:2
"A signal transducer and activator of transcription 1 isoform 1 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. UniProtKB:P42224-1, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-873792, Reactome:R-HSA-909563]

organism-sequence


PR:P42225-1
signal transducer and activator of transcription 1 isoform 1 (mouse)
mSTAT1/iso:1
"A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000003075
signal transducer and activator of transcription 1 isoform 1 phosphorylated form
STAT1/iso:1/PhosRes+
"A signal transducer and activator of transcription 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003076
signal transducer and activator of transcription 1 isoform 1 phosphorylated 1
STAT1/iso:1/Phos:1
"A signal transducer and activator of transcription 1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the conserved GYI sequence following the SH2 domain. Example: UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7543024, PRO:CNA]

organism-modification


PR:000026858
signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 (human)
hSTAT1/iso:1/Phos:1
"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 in human. UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7657660, PRO:CNA, Reactome:R-HSA-873791, Reactome:R-HSA-909684]

modification


PR:000027888
signal transducer and activator of transcription 1 isoform 1 phosphorylated 3
STAT1/iso:1/Phos:3
"A signal transducer and activator of transcription 1 isoform 1 phosphorylated form that has been modified on a Ser residue located in the conserved PMSP sequence at the C-terminal transactivation domain. Example: UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]

organism-modification


PR:000027889
signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)
hSTAT1/iso:1/Phos:3
"A signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 in human. UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]
Yes
organism-modification


PR:000061402
signal transducer and activator of transcription 1 isoform 1 phosphorylated 2 (human)
hSTAT1/iso:1/Phos:2
"A signal transducer and activator of transcription 1 isoform 1 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-701 and Ser-727 of the amino acid sequence represented by UniProtKB:P42224-1. UniProtKB:P42224-1, Tyr-701, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-873792, Reactome:R-HSA-909563]

modification


PR:000027890
signal transducer and activator of transcription 1 isoform 1 sumoylated 1
STAT1/iso:1/Sumo:1
"A signal transducer and activator of transcription 1 isoform 1 that has been modified on a Lys residue located right after the conserved GYI sequence in the C-terminal region. PIAS proteins promote this modification in response to IFN-gamma signaling. Example: UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]

organism-modification


PR:000027891
signal transducer and activator of transcription 1 isoform 1 sumoylated 1 (human)
hSTAT1/iso:1/Sumo:1
"A signal transducer and activator of transcription 1 isoform 1 sumoylated 1 in human. UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]

modification


PR:000028636
signal transducer and activator of transcription 1 isoform 1 acetylated 1
STAT1/iso:1/Ac:1
"A signal transducer and activator of transcription 1 isoform 1 that has been acetylated on Lys residues within the DNA binding domain. Example: UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]

organism-modification


PR:000028637
signal transducer and activator of transcription 1 isoform 1 acetylated 1 (human)
hSTAT1/iso:1/Ac:1
"A signal transducer and activator of transcription 1 isoform 1 acetylated 1 in human. UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027889 hSTAT1/iso:1/Phos:3
UniProtKB:P42224-1, Ser-727, MOD:00046		 acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process PMID:15322115
located_inGO:0005634 nucleus PMID:15322115