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Protein Ontology report - neuropilin-1 isoform 1

PR:000003078 - http://purl.obolibrary.org/obo/PR_000003078

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000003078

PRO name

neuropilin-1 isoform 1

Synonyms

PRO-Short-label:	EXACT:	NRP1/iso:1
Other:	EXACT:	membrane-bound NRP1

Definition

"A neuropilin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14786-1 or a 1:1 ortholog thereof." [PMID:9529250, PRO:CNA]

PRO Category

sequence

Parent

PR:000001900 neuropilin-1

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	2
Modification	4	Organism-Modification	3

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

sequence

PR:000003078 neuropilin-1 isoform 1

NRP1/iso:1

organism-sequence

PR:O14786-1 neuropilin-1 isoform 1 (human)

hNRP1/iso:1

organism-modification

PR:000036635 neuropilin-1 isoform 1, signal peptide removed form (human)

hNRP1/iso:1/SigPep-

Yes

organism-modification

PR:000036631 neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1

Yes

organism-modification

PR:000036632 neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2

Yes

organism-sequence

PR:P97333-1 neuropilin-1 isoform 1 (mouse)

mNRP1/iso:1

modification

PR:000003095 neuropilin-1 isoform 1, signal peptide removed form

NRP1/iso:1/SigPep-

modification

PR:000003081 neuropilin-1 isoform 1, signal peptide removed glycosylated form

NRP1/iso:1/SigPep-/GlycoRes+

modification

PR:000003082 neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1

NRP1/iso:1/SigPep-/OGlyco:1

organism-modification

PR:000036631 neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1

Yes

modification

PR:000003083 neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2

NRP1/iso:1/SigPep-/OGlyco:2

organism-modification

PR:000036632 neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2

Yes

organism-modification

PR:000036635 neuropilin-1 isoform 1, signal peptide removed form (human)

hNRP1/iso:1/SigPep-

Yes

organism-modification

PR:000036631 neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)

hNRP1/iso:1/ClvOGlyco:1

Yes

organism-modification

PR:000036632 neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)

hNRP1/iso:1/ClvOGlyco:2

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036631 hNRP1/iso:1/ClvOGlyco:1 UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215	acts_upstream_of_or_within	GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway	PMID:16763549
	enables	increased GO:0005515 protein binding with PR:P15692-4	PMID:16763549
	enables	GO:0043184 vascular endothelial growth factor receptor 2 binding	PMID:16763549
PR:000036632 hNRP1/iso:1/ClvOGlyco:2 UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213	acts_upstream_of_or_within	GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway	PMID:16763549
	enables	increased GO:0005515 protein binding with PR:P15692-4	PMID:16763549
	enables	decreased GO:0043184 vascular endothelial growth factor receptor 2 binding relative to PR:000036635 hNRP1/iso:1/SigPep-	PMID:16763549
PR:000036635 hNRP1/iso:1/SigPep- UniProtKB:O14786-1, 22-923	enables	GO:0005515 protein binding with PR:P15692-4	PMID:11986311
		GO:0005515 protein binding with PR:P15692-4	PMID:11986311
		GO:0005515 protein binding with PR:P49763-3	PMID:11986311
		GO:0008201 heparin binding	PMID:11986311
		GO:0043184 vascular endothelial growth factor receptor 2 binding	PMID:16763549