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Protein Ontology report - NF-kappa-B inhibitor
PR:000003292 - http://purl.obolibrary.org/obo/PR_000003292
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000003292   
  PRO nameNF-kappa-B inhibitor 
  Synonyms
Other: RELATED:IKB
  Definition"A protein that is a translation product of the human NFKBIA, NFKBIB, or NFKBIE genes, 1:1 orthologs thereof, or a semi-ortholog thereof. It contains multiple copies of the Ankyrin repeats (Pfam:PF00023 or Pfam:PF12796)." [PRO:CNA, PRO:DAN] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 9                                        
         Sequence1                                                  Organism-Sequence 6                                        
         Modification2                                                  Organism-Modification 22                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF036322
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
family



PR:000003292

NF-kappa-B inhibitor

UBE2V1


"A protein that is a translation product of the human NFKBIA, NFKBIB, or NFKBIE genes, 1:1 orthologs thereof, or a semi-ortholog thereof. It contains multiple copies of the Ankyrin repeats (Pfam:PF00023 or Pfam:PF12796)." [PRO:CNA, PRO:DAN]


gene



PR:000003293

NF-kappa-B inhibitor alpha

NFKBIA


"An NF-kappa-B inhibitor that is a translation product of the human NFKBIA gene or a 1:1 ortholog thereof." [PMID:19302050, TLR:AMM]


organism-gene



PR:P25963

NF-kappa-B inhibitor alpha (human)

hNFKBIA


"An NF-kappa-B inhibitor alpha that is encoded in the genome of human." [TLR:AMM, UniProtKB:P25963]


organism-sequence



PR:000063143

NF-kappa-B inhibitor alpha sequence variant M37K (human)

hNFKBIA/var:M37K


"An NF-kappa-B inhibitor alpha (human) that has a Lys residue at the position equivalent to Met-37 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Met-37, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-5228805]


organism-sequence



PR:000064097

NF-kappa-B inhibitor alpha sequence variant S32I (human)

hNFKBIA/var:S32I


"An NF-kappa-B inhibitor alpha (human) that has an Ile residue at the position equivalent to Ser-32 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Ser-32, CHEBI:30009." [PRO:DNx, Reactome:R-HSA-5228846]


organism-sequence



PR:P25963-1

NF-kappa-B inhibitor alpha isoform 1 (human)

hNFKBIA/iso:1


"An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028546

NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (human)

hNFKBIA/iso:1/Phos:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in human. UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]


organism-modification



PR:000028548

NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)

hNFKBIA/iso:1/PhosUbiq:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]


organism-modification



PR:000045728

NF-kappa-B inhibitor alpha phosphorylated 1 (human)

hNFKBIA/Phos:1


"An NF-kappa-B inhibitor alpha (human) that has been phosphorylated at Tyr-42. UniProtKB:P25963, Tyr-42, MOD:00048." [iPTMnet:P25963, PMID:12429743, PMID:12432072]


organism-modification



PR:000048597

NF-kappa-B inhibitor alpha ubiquitinated form (human)

hNFKBIA/UbiqLys+


"An NF-kappa-B inhibitor alpha (human) that includes at least one ubiquitinated lysine. UniProtKB:P25963, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782960]


organism-modification



PR:000028548

NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)

hNFKBIA/iso:1/PhosUbiq:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]


organism-modification



PR:000061305

NF-kappa-B inhibitor alpha phosphorylated 2 (human)

hNFKBIA/Phos:2


"An NF-kappa-B inhibitor alpha (human) that has been phosphorylated on the residues at the positions equivalent to Ser-32 and Ser-36 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Ser-32/Ser-36, MOD:00046." [PRO:DNx, Reactome:R-HSA-177677]


organism-modification



PR:000064833

NF-kappa-B inhibitor alpha sumoylated 1 (human)

hNFKBIA/Sumo:1


"An NF-kappa-B inhibitor alpha (human) that has been sumoylated on the residue at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Lys-21, MOD:01149." [PRO:DNx, Reactome:R-HSA-4656935]


organism-modification



PR:000076169

NF-kappa-B inhibitor alpha methylated 1 (human)

hNFKBIA/Me:1


"An NF-kappa-B inhibitor alpha (human) that has been methylated on the residue at the position equivalent to Cys-215 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-215, MOD:00660." [IEDB_epitope:1001669, IEDB_epitope:1008801, PRO:DNx]


organism-modification



PR:000079620

NF-kappa-B inhibitor alpha cysteinylated 1 (human)

hNFKBIA/Cyst:1


"An NF-kappa-B inhibitor alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-135 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-135, MOD:00765." [IEDB_epitope:629210, PRO:DNx]


organism-modification



PR:000080276

NF-kappa-B inhibitor alpha methylated 2 (human)

hNFKBIA/Me:2


"An NF-kappa-B inhibitor alpha (human) that has been methylated on the residue at the position equivalent to Cys-186 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-186, MOD:00660." [IEDB_epitope:1019437, IEDB_epitope:1036565, PRO:DNx]


organism-modification



PR:000080277

NF-kappa-B inhibitor alpha cysteinylated 2 (human)

hNFKBIA/Cyst:2


"An NF-kappa-B inhibitor alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-308 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-308, MOD:00765." [IEDB_epitope:1031108, PRO:DNx]


organism-modification



PR:000084510

NF-kappa-B inhibitor alpha cysteinylated 3 (human)

hNFKBIA/Cyst:3


"An NF-kappa-B inhibitor alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-167 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-167, MOD:00765." [IEDB_epitope:1004338, PRO:DNx]


organism-gene



PR:Q63746

NF-kappa-B inhibitor alpha (rat)

rNFKBIA


"An NF-kappa-B inhibitor alpha that is encoded in the genome of rat." [OMA:Q63746, PRO:DNx]


organism-gene



PR:Q91974

NF-kappa-B inhibitor alpha (chicken)

chick-NFKBIA


"An NF-kappa-B inhibitor alpha that is encoded in the genome of chicken." [OMA:Q91974, PRO:DNx]


organism-gene



PR:Q9Z1E3

NF-kappa-B inhibitor alpha (mouse)

mNFKBIA


"An NF-kappa-B inhibitor alpha that is encoded in the genome of mouse." [OMA:Q9Z1E3, PRO:DNx]


organism-sequence



PR:Q9Z1E3-1

NF-kappa-B inhibitor alpha isoform 1 (mouse)

mNFKBIA/iso:1


"An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000028550

NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (mouse)

mNFKBIA/iso:1/Phos:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z1E3-1, Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]


organism-modification



PR:000028551

NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (mouse)

mNFKBIA/iso:1/PhosUbiq:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q9Z1E3-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]


sequence



PR:000028543

NF-kappa-B inhibitor alpha isoform 1

NFKBIA/iso:1


"An NF-kappa-B inhibitor alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25963-1 or a 1:1 ortholog thereof." [PMID:10329681, PRO:CNA]


organism-sequence



PR:P25963-1

NF-kappa-B inhibitor alpha isoform 1 (human)

hNFKBIA/iso:1


"An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028546

NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (human)

hNFKBIA/iso:1/Phos:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in human. UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]


organism-modification



PR:000028548

NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)

hNFKBIA/iso:1/PhosUbiq:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]


organism-sequence



PR:Q9Z1E3-1

NF-kappa-B inhibitor alpha isoform 1 (mouse)

mNFKBIA/iso:1


"An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000028550

NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (mouse)

mNFKBIA/iso:1/Phos:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z1E3-1, Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]


organism-modification



PR:000028551

NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (mouse)

mNFKBIA/iso:1/PhosUbiq:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q9Z1E3-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]


modification



PR:000028545

NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1

NFKBIA/iso:1/Phos:1


"An NF-kappa-B inhibitor alpha isoform 1 that has been phosphorylated on the Ser residues in the motif KKx(8-11)SDGxxS. Example: UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PMID:10837071, PRO:CNA]


organism-modification



PR:000028546

NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (human)

hNFKBIA/iso:1/Phos:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in human. UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]


organism-modification



PR:000028550

NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (mouse)

mNFKBIA/iso:1/Phos:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z1E3-1, Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]


modification



PR:000028547

NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1

NFKBIA/iso:1/PhosUbiq:1


"An NF-kappa-B inhibitor alpha isoform 1 that has been phosphorylated on the Ser residues in the motif KKx(8-11)SDGxxS and subsequently ubiquitinated on the Lys residues of the same motif. This modification targets the protein to proteosome degradation. Example: UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PMID:10837071, PRO:CNA]


organism-modification



PR:000028548

NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)

hNFKBIA/iso:1/PhosUbiq:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]


organism-modification



PR:000028551

NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (mouse)

mNFKBIA/iso:1/PhosUbiq:1


"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q9Z1E3-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]


gene



PR:000003294

NF-kappa-B inhibitor beta

NFKBIB


"An NF-kappa-B inhibitor that is a translation product of the human NFKBIB gene or a 1:1 ortholog thereof." [PMID:19302050, TLR:AMM]


organism-gene



PR:Q15653

NF-kappa-B inhibitor beta (human)

hNFKBIB


"An NF-kappa-B inhibitor beta that is encoded in the genome of human." [TLR:AMM, UniProtKB:Q15653]


organism-sequence



PR:Q15653-1

NF-kappa-B inhibitor beta isoform h1 (human)

hNFKBIB/iso:h1


"An NF-kappa-B inhibitor beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15653-1." [PRO:DNx, UniProtKB:Q15653]


organism-sequence



PR:Q15653-2

NF-kappa-B inhibitor beta isoform h2 (human)

hNFKBIB/iso:h2


"An NF-kappa-B inhibitor beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15653-2." [PRO:DNx, UniProtKB:Q15653]


organism-modification



PR:000048598

NF-kappa-B inhibitor beta phosphorylated 1 (human)

hNFKBIB/Phos:1


"An NF-kappa-B inhibitor beta (human) that has been post-translationally modified to include phosphoserine at positions 19 and 23 of the amino acid sequence represented by UniProtKB:Q15653. UniProtKB:Q15653, Ser-19/Ser-23, MOD:00046." [PRO:DNx, Reactome:R-HSA-177670]


organism-modification



PR:000064729

NF-kappa-B inhibitor beta phosphorylated and ubiquitinated 1 (human)

hNFKBIB/PhosUbiq:1


"An NF-kappa-B inhibitor beta (human) that has been phosphorylated on the residues at the positions equivalent to Ser-19 and Ser-23 of the amino acid sequence represented by UniProtKB:Q15653-1 and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:Q15653-1, Ser-19/Ser-23, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-1168571]


organism-modification



PR:000074070

NF-kappa-B inhibitor beta methylated 1 (human)

hNFKBIB/Me:1


"An NF-kappa-B inhibitor beta (human) that has been methylated on the residue at the position equivalent to Cys-121 of the amino acid sequence represented by UniProtKB:Q15653-1. Example: UniProtKB:Q15653-1, Cys-121, MOD:00660." [IEDB_epitope:1060502, PRO:DNx]


organism-gene



PR:Q60778

NF-kappa-B inhibitor beta (mouse)

mNFKBIB


"An NF-kappa-B inhibitor beta that is encoded in the genome of mouse." [OMA:Q60778, PRO:DNx]


organism-gene



PR:Q9JIA3

NF-kappa-B inhibitor beta (rat)

rNFKBIB


"An NF-kappa-B inhibitor beta that is encoded in the genome of rat." [OMA:Q9JIA3, PRO:DNx]


gene



PR:000003295

NF-kappa-B inhibitor epsilon

NFKBIE


"An NF-kappa-B inhibitor that is a translation product of the human NFKBIE gene or a 1:1 ortholog thereof." [PMID:19302050, TLR:AMM]


organism-gene



PR:O00221

NF-kappa-B inhibitor epsilon (human)

hNFKBIE


"An NF-kappa-B inhibitor epsilon that is encoded in the genome of human." [TLR:AMM, UniProtKB:O00221]


organism-modification



PR:000048599

NF-kappa-B inhibitor epsilon phosphorylated 1 (human)

hNFKBIE/Phos:1


"An NF-kappa-B inhibitor epsilon (human) that has been post-translationally modified to include phosphoserine at positions 157 and 161 of the amino acid sequence represented by UniProtKB:O00221. UniProtKB:O00221, Ser-157/Ser-161, MOD:00046." [PRO:DNx, Reactome:R-HSA-1168561]


organism-modification



PR:000064783

NF-kappa-B inhibitor epsilon phosphorylated and ubiquitinated 1 (human)

hNFKBIE/PhosUbiq:1


"An NF-kappa-B inhibitor epsilon (human) that has been phosphorylated on the residues at the positions equivalent to Ser-157 and Ser-161 of the amino acid sequence represented by UniProtKB:O00221 and that includes at least 1 ubiquitinated lysine. UniProtKB:O00221, Ser-157/Ser-161, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-1168563]


organism-modification



PR:000070018

NF-kappa-B inhibitor epsilon cysteinylated 1 (human)

hNFKBIE/Cyst:1


"An NF-kappa-B inhibitor epsilon (human) that has been cysteinylated on the residue at the position equivalent to Cys-342 of the amino acid sequence represented by UniProtKB:O00221. UniProtKB:O00221, Cys-342, MOD:00765." [IEDB_epitope:1038232, PRO:DNx]


organism-modification



PR:000075245

NF-kappa-B inhibitor epsilon cysteinylated 2 (human)

hNFKBIE/Cyst:2


"An NF-kappa-B inhibitor epsilon (human) that has been cysteinylated on the residue at the position equivalent to Cys-277 of the amino acid sequence represented by UniProtKB:O00221. UniProtKB:O00221, Cys-277, MOD:00765." [IEDB_epitope:1007209, PRO:DNx]


organism-modification



PR:000078458

NF-kappa-B inhibitor epsilon methylated 1 (human)

hNFKBIE/Me:1


"An NF-kappa-B inhibitor epsilon (human) that has been methylated on the residue at the position equivalent to Cys-373 of the amino acid sequence represented by UniProtKB:O00221. UniProtKB:O00221, Cys-373, MOD:00660." [IEDB_epitope:1028077, PRO:DNx]


organism-modification



PR:000084609

NF-kappa-B inhibitor epsilon methylated 2 (human)

hNFKBIE/Me:2


"An NF-kappa-B inhibitor epsilon (human) that has been methylated on the residue at the position equivalent to Cys-335 of the amino acid sequence represented by UniProtKB:O00221. UniProtKB:O00221, Cys-335, MOD:00660." [IEDB_epitope:1053251, PRO:DNx]


organism-gene



PR:O54910

NF-kappa-B inhibitor epsilon (mouse)

mNFKBIE


"An NF-kappa-B inhibitor epsilon that is encoded in the genome of mouse." [TLR:AMM]