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Protein Ontology report - thyroid hormone receptor alpha
PR:000003428 - http://purl.obolibrary.org/obo/PR_000003428
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003428   
  PRO namethyroid hormone receptor alpha 
  Synonyms
PRO-Short-label: EXACT:THRA
Gene-based: RELATED:EAR7 | ERBA1 | NR1A1 | THRA1 | THRA2
Other: EXACT:c-erbA-1 | c-erbA-alpha | EAR-7 | nuclear receptor subfamily 1 group A member 1 | TR-alpha | V-erbA-related protein 7
  Definition"A protein that is a translation product of the human THRA gene or a 1:1 ortholog thereof." [MGI:98742, PRO:HJD] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 10                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:588
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
gene


PR:000003428 thyroid hormone receptor alpha
THRA

organism-gene


PR:P04625 thyroid hormone receptor alpha (chicken)
chick-THRA

organism-gene


PR:P10827 thyroid hormone receptor alpha (human)
hTHRA

organism-sequence


PR:P10827-1 thyroid hormone receptor alpha isoform Alpha-2 (human)
hTHRA/iso:Alpha-2

organism-sequence


PR:P10827-2 thyroid hormone receptor alpha isoform Alpha-1 (human)
hTHRA/iso:Alpha-1

organism-modification


PR:000064694 thyroid hormone receptor alpha isoform Alpha-1 sumoylated 1 (human)
hTHRA/iso:Alpha-1/Sumo:1

organism-sequence


PR:P10827-3 thyroid hormone receptor alpha isoform Alpha-3 (human)
hTHRA/iso:Alpha-3

organism-sequence


PR:P10827-4 thyroid hormone receptor alpha isoform hAlpha-4 (human)
hTHRA/iso:hAlpha-4

organism-gene


PR:P63058 thyroid hormone receptor alpha (mouse)
mTHRA
Yes
organism-sequence


PR:P63058-1 thyroid hormone receptor alpha isoform Alpha-2 (mouse)
mTHRA/iso:Alpha-2
Yes
organism-sequence


PR:P63058-2 thyroid hormone receptor alpha isoform Alpha-1 (mouse)
mTHRA/iso:Alpha-1
Yes
organism-sequence


PR:P63058-3 thyroid hormone receptor alpha isoform Alpha-3 (mouse)
mTHRA/iso:Alpha-3

organism-sequence


PR:P63058-4 thyroid hormone receptor alpha isoform Alpha-deltaE6 (mouse)
mTHRA/iso:Alpha-deltaE6
Yes
sequence


PR:000003429 thyroid hormone receptor alpha isoform Alpha-2
THRA/iso:Alpha-2

organism-sequence


PR:P10827-1 thyroid hormone receptor alpha isoform Alpha-2 (human)
hTHRA/iso:Alpha-2

organism-sequence


PR:P63058-1 thyroid hormone receptor alpha isoform Alpha-2 (mouse)
mTHRA/iso:Alpha-2
Yes
organism-sequence


PR:P63059-1 thyroid hormone receptor alpha isoform Alpha-2 (rat)
rTHRA/iso:Alpha-2

sequence


PR:000022013 thyroid hormone receptor alpha isoform Alpha-1
THRA/iso:Alpha-1

organism-sequence


PR:P10827-2 thyroid hormone receptor alpha isoform Alpha-1 (human)
hTHRA/iso:Alpha-1

organism-modification


PR:000064694 thyroid hormone receptor alpha isoform Alpha-1 sumoylated 1 (human)
hTHRA/iso:Alpha-1/Sumo:1

organism-sequence


PR:P63058-2 thyroid hormone receptor alpha isoform Alpha-1 (mouse)
mTHRA/iso:Alpha-1
Yes
organism-sequence


PR:P63059-2 thyroid hormone receptor alpha isoform Alpha-1 (rat)
rThra/iso:Alpha-1

sequence


PR:000022014 thyroid hormone receptor alpha isoform Alpha-3
THRA/iso:Alpha-3

organism-sequence


PR:P10827-3 thyroid hormone receptor alpha isoform Alpha-3 (human)
hTHRA/iso:Alpha-3

organism-sequence


PR:P63058-3 thyroid hormone receptor alpha isoform Alpha-3 (mouse)
mTHRA/iso:Alpha-3

sequence


PR:000022015 thyroid hormone receptor alpha isoform Alpha-deltaE6
THRA/iso:Alpha-deltaE6

organism-sequence


PR:P63058-4 thyroid hormone receptor alpha isoform Alpha-deltaE6 (mouse)
mTHRA/iso:Alpha-deltaE6
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P63058 mTHRA acts_upstream_of_or_withinGO:0001502 cartilage condensation PMID:9250685
GO:0001503 ossification PMID:9927422
GO:0001503 ossification PMID:9927422
GO:0007611 learning or memory PMID:17129617
GO:0008016 regulation of heart contraction PMID:9430637
GO:0008016 regulation of heart contraction PMID:9430637
GO:0009887 animal organ morphogenesis PMID:9927422
PR:P63058-1 mTHRA/iso:Alpha-2 acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PMID:11641275; PMID:15062575
enablesGO:0005515 protein binding with PR:Q61645 [histone H3]-dimethyl-L-lysine(9) demethylase hairless (mouse) PMID:15322135
GO:0005515 protein binding with PR:Q924W6 mTRIM66 PMID:15322135
PR:P63058-2 mTHRA/iso:Alpha-1 enablesGO:0002153 steroid receptor RNA activator RNA binding MGI_ref:3050934; PMID:15180993
GO:0003727 single-stranded RNA binding MGI_ref:3050934; PMID:15180993
PR:P63058-4 mTHRA/iso:Alpha-deltaE6 acts_upstream_of_or_withinGO:0010831 positive regulation of myotube differentiation MGI_ref:3619869; PMID:16322094
GO:0042994 cytoplasmic sequestering of transcription factor MGI_ref:3619869; PMID:16322094
located_inGO:0005737 cytoplasm MGI_ref:3619869; PMID:16322094