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Protein Ontology report - double-stranded RNA-specific adenosine deaminase
PR:000003745 - http://purl.obolibrary.org/obo/PR_000003745
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003745   
  PRO namedouble-stranded RNA-specific adenosine deaminase 
  Synonyms
PRO-Short-label: EXACT:ADAR
Gene-based: RELATED:ADAR1 | DSRAD | G1P1 | IFI4
Other: EXACT:136 kDa double-stranded RNA-binding protein | DRADA | IFI-4 | interferon-inducible protein 4 | K88DSRBP | RNA adenosine deaminase 1
  Definition"A protein that is a translation product of the human ADAR gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence5                                                  Organism-Sequence 10                                        
         Modification0                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000003745

double-stranded RNA-specific adenosine deaminase

ADAR


"A protein that is a translation product of the human ADAR gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:H9L3K3

uncharacterized protein, ADAR translation product (chicken)

chick-ADAR


"A double-stranded RNA-specific adenosine deaminase that is encoded in the genome of chicken." [PRO:DNx]


organism-gene



PR:P55265

double-stranded RNA-specific adenosine deaminase (human)

hADAR


"A double-stranded RNA-specific adenosine deaminase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55265]


organism-sequence



PR:P55265-1

double-stranded RNA-specific adenosine deaminase isoform 1 (human)

hADAR/iso:1


"A double-stranded RNA-specific adenosine deaminase isoform 1 that is encoded in the genome of human." [PMID:10200312, PRO:CNA]


organism-sequence



PR:P55265-2

double-stranded RNA-specific adenosine deaminase isoform h2 (human)

hADAR/iso:h2


"A double-stranded RNA-specific adenosine deaminase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55265-2." [PRO:DNx, UniProtKB:P55265]


organism-sequence



PR:P55265-3

double-stranded RNA-specific adenosine deaminase isoform h3 (human)

hADAR/iso:h3


"A double-stranded RNA-specific adenosine deaminase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55265-3." [PRO:DNx, UniProtKB:P55265]


organism-sequence



PR:P55265-4

double-stranded RNA-specific adenosine deaminase isoform h4 (human)

hADAR/iso:h4


"A double-stranded RNA-specific adenosine deaminase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55265-4." [PRO:DNx, UniProtKB:P55265]


organism-sequence



PR:P55265-5

double-stranded RNA-specific adenosine deaminase isoform 5 (human)

hADAR/iso:5


"A double-stranded RNA-specific adenosine deaminase isoform 5 that is encoded in the genome of human." [PMID:10200312, PRO:CNA]


organism-modification



PR:000065283

double-stranded RNA-specific adenosine deaminase cysteinylated 1 (human)

hADAR/Cyst:1


"A double-stranded RNA-specific adenosine deaminase (human) that has been cysteinylated on the residue at the position equivalent to Cys-304 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Cys-304, MOD:00765." [IEDB_epitope:877187, PRO:DNx]


organism-modification



PR:000065658

double-stranded RNA-specific adenosine deaminase methylated 1 (human)

hADAR/Me:1


"A double-stranded RNA-specific adenosine deaminase (human) that has been methylated on the residue at the position equivalent to Cys-630 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Cys-630, MOD:00660." [IEDB_epitope:1018148, PRO:DNx]


organism-modification



PR:000066334

double-stranded RNA-specific adenosine deaminase methylated 2 (human)

hADAR/Me:2


"A double-stranded RNA-specific adenosine deaminase (human) that has been methylated on the residue at the position equivalent to Cys-304 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Cys-304, MOD:00660." [IEDB_epitope:1008066, IEDB_epitope:1024104, IEDB_epitope:998416, PRO:DNx]


organism-modification



PR:000067507

double-stranded RNA-specific adenosine deaminase deaminated 1 (human)

hADAR/Deam:1


"A double-stranded RNA-specific adenosine deaminase (human) that has been deaminated on the residue at the position equivalent to Asn-1127 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Asn-1127, MOD:00684." [IEDB_epitope:774846, PRO:DNx]


organism-modification



PR:000067792

double-stranded RNA-specific adenosine deaminase methylated 3 (human)

hADAR/Me:3


"A double-stranded RNA-specific adenosine deaminase (human) that has been methylated on the residue at the position equivalent to Arg-74 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Arg-74, MOD:00658." [IEDB_epitope:569295, IEDB_epitope:569297, PRO:DNx]


organism-modification



PR:000072266

double-stranded RNA-specific adenosine deaminase methylated 4 (human)

hADAR/Me:4


"A double-stranded RNA-specific adenosine deaminase (human) that has been methylated on the residue at the position equivalent to Cys-1036 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Cys-1036, MOD:00660." [IEDB_epitope:1046227, PRO:DNx]


organism-modification



PR:000078393

double-stranded RNA-specific adenosine deaminase cysteinylated 2 (human)

hADAR/Cyst:2


"A double-stranded RNA-specific adenosine deaminase (human) that has been cysteinylated on the residue at the position equivalent to Cys-1036 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Cys-1036, MOD:00765." [IEDB_epitope:930579, PRO:DNx]


organism-modification



PR:000082540

double-stranded RNA-specific adenosine deaminase methylated 5 (human)

hADAR/Me:5


"A double-stranded RNA-specific adenosine deaminase (human) that has been methylated on the residue at the position equivalent to Arg-114 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Arg-114, MOD:00658." [IEDB_epitope:569140, PRO:DNx]


organism-modification



PR:000083821

double-stranded RNA-specific adenosine deaminase methylated 6 (human)

hADAR/Me:6


"A double-stranded RNA-specific adenosine deaminase (human) that has been methylated on the residue at the position equivalent to Cys-893 of the amino acid sequence represented by UniProtKB:P55265-1. Example: UniProtKB:P55265-1, Cys-893, MOD:00660." [IEDB_epitope:1036069, PRO:DNx]


organism-gene



PR:P55266

double-stranded RNA-specific adenosine deaminase (rat)

rADAR


"A double-stranded RNA-specific adenosine deaminase that is encoded in the genome of rat." [OMA:P55266, PRO:DNx]


organism-gene



PR:Q99MU3

double-stranded RNA-specific adenosine deaminase (mouse)

mADAR


"A double-stranded RNA-specific adenosine deaminase that is encoded in the genome of mouse." [OMA:Q99MU3, PRO:DNx]


organism-sequence



PR:Q99MU3-1

double-stranded RNA-specific adenosine deaminase isoform 1 (mouse)

mADAR/iso:1


"A double-stranded RNA-specific adenosine deaminase isoform 1 that is encoded in the genome of mouse." [PMID:12954622, PRO:HJD]

Yes

organism-sequence



PR:Q99MU3-2

double-stranded RNA-specific adenosine deaminase isoform 2 (mouse)

mADAR/iso:2


"A double-stranded RNA-specific adenosine deaminase isoform 2 that is encoded in the genome of mouse. This form is produced by alternative splicing of isoform 1." [PMID:12954622, PRO:HJD]

Yes

organism-sequence



PR:Q99MU3-3

double-stranded RNA-specific adenosine deaminase isoform 3 (mouse)

mADAR/iso:3


"A double-stranded RNA-specific adenosine deaminase isoform 3 that is encoded in the genome of mouse. This form is produced by alternative splicing of isoform 1." [PMID:12954622, PRO:HJD]

Yes

organism-sequence



PR:Q99MU3-4

double-stranded RNA-specific adenosine deaminase isoform 4 (mouse)

mADAR/iso:4


"A double-stranded RNA-specific adenosine deaminase isoform 4 that is encoded in the genome of mouse. Produced by alternative splicing of isoform 1." [PMID:12954622, PRO:HJD]

Yes

organism-sequence



PR:Q99MU3-5

double-stranded RNA-specific adenosine deaminase isoform 5 (mouse)

mADAR/iso:5


"A double-stranded RNA-specific adenosine deaminase isoform 5 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000037168

double-stranded RNA-specific adenosine deaminase isoform 1

ADAR/iso:1


"A double-stranded RNA-specific adenosine deaminase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99MU3-1 or a 1:1 ortholog thereof. This form is produced by alternative promoter usage." [PMID:10200312, PRO:CNA]


organism-sequence



PR:P55265-1

double-stranded RNA-specific adenosine deaminase isoform 1 (human)

hADAR/iso:1


"A double-stranded RNA-specific adenosine deaminase isoform 1 that is encoded in the genome of human." [PMID:10200312, PRO:CNA]


organism-sequence



PR:Q99MU3-1

double-stranded RNA-specific adenosine deaminase isoform 1 (mouse)

mADAR/iso:1


"A double-stranded RNA-specific adenosine deaminase isoform 1 that is encoded in the genome of mouse." [PMID:12954622, PRO:HJD]

Yes

sequence



PR:000037170

double-stranded RNA-specific adenosine deaminase isoform 2

ADAR/iso:2


"A double-stranded RNA-specific adenosine deaminase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99MU3-2 or a 1:1 ortholog thereof." [PMID:12954622, PRO:HJD]


organism-sequence



PR:Q99MU3-2

double-stranded RNA-specific adenosine deaminase isoform 2 (mouse)

mADAR/iso:2


"A double-stranded RNA-specific adenosine deaminase isoform 2 that is encoded in the genome of mouse. This form is produced by alternative splicing of isoform 1." [PMID:12954622, PRO:HJD]

Yes

sequence



PR:000037172

double-stranded RNA-specific adenosine deaminase isoform 3

ADAR/iso:3


"A double-stranded RNA-specific adenosine deaminase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99MU3-3 or a 1:1 ortholog thereof." [PMID:12954622, PRO:HJD]


organism-sequence



PR:Q99MU3-3

double-stranded RNA-specific adenosine deaminase isoform 3 (mouse)

mADAR/iso:3


"A double-stranded RNA-specific adenosine deaminase isoform 3 that is encoded in the genome of mouse. This form is produced by alternative splicing of isoform 1." [PMID:12954622, PRO:HJD]

Yes

sequence



PR:000037174

double-stranded RNA-specific adenosine deaminase isoform 4

ADAR/iso:4


"A double-stranded RNA-specific adenosine deaminase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99MU3-4 or a 1:1 ortholog thereof." [PMID:12954622, PRO:HJD]


organism-sequence



PR:Q99MU3-4

double-stranded RNA-specific adenosine deaminase isoform 4 (mouse)

mADAR/iso:4


"A double-stranded RNA-specific adenosine deaminase isoform 4 that is encoded in the genome of mouse. Produced by alternative splicing of isoform 1." [PMID:12954622, PRO:HJD]

Yes

sequence



PR:000037176

double-stranded RNA-specific adenosine deaminase isoform 5

ADAR/iso:5


"A double-stranded RNA-specific adenosine deaminase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99MU3-5 or a 1:1 ortholog thereof. This form is produced by alternative promoter usage." [PMID:10200312, PRO:CNA]


organism-sequence



PR:P55265-5

double-stranded RNA-specific adenosine deaminase isoform 5 (human)

hADAR/iso:5


"A double-stranded RNA-specific adenosine deaminase isoform 5 that is encoded in the genome of human." [PMID:10200312, PRO:CNA]


organism-sequence



PR:Q99MU3-5

double-stranded RNA-specific adenosine deaminase isoform 5 (mouse)

mADAR/iso:5


"A double-stranded RNA-specific adenosine deaminase isoform 5 that is encoded in the genome of mouse." [PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q99MU3-1 mADAR/iso:1 acts_upstream_of_or_withinGO:0001701 in utero embryonic development MGI_ref:4939544; PMID:21173229
GO:0045071 negative regulation of viral genome replication MGI_ref:4939544; PMID:21173229
GO:0051607 defense response to virus MGI_ref:4939544; PMID:21173229
enablesGO:0003726 double-stranded RNA adenosine deaminase activity MGI_ref:5515381; PMID:12954622
located_inGO:0005737 cytoplasm MGI_ref:5515381; PMID:12954622
PR:Q99MU3-2 mADAR/iso:2
This form is produced by alternative splicing of isoform 1
enablesGO:0003726 double-stranded RNA adenosine deaminase activity MGI_ref:5515381; PMID:12954622
located_inGO:0005737 cytoplasm MGI_ref:5515381; PMID:12954622
PR:Q99MU3-3 mADAR/iso:3
This form is produced by alternative splicing of isoform 1
enablesGO:0003726 double-stranded RNA adenosine deaminase activity MGI_ref:5515381; PMID:12954622
located_inGO:0005730 nucleolus MGI_ref:5515381; PMID:12954622
PR:Q99MU3-4 mADAR/iso:4
Produced by alternative splicing of isoform 1
enablesGO:0003726 double-stranded RNA adenosine deaminase activity MGI_ref:5515381; PMID:12954622