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RACE-PRO
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Documentation
Protein Ontology report - aurora kinase B
PR:000004517 -
http://purl.obolibrary.org/obo/PR_000004517
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000004517
PRO name
aurora kinase B
Synonyms
PRO-Short-label
:
EXACT:
AURKB
Gene-based
:
RELATED:
AIK2 | AIM1 | AIRK2 | ARK2 | STK12
Other
:
EXACT:
AIM-1 | ARK-2 | aurora 1 | aurora- and Ipl1-like midbody-associated protein 1 | aurora-related kinase 2 | aurora/IPL1-related kinase 2 | serine/threonine-protein kinase 12 | serine/threonine-protein kinase 5 | serine/threonine-protein kinase aurora-B
RELATED:
STK-1 | Stk1 | Stk5
Definition
"An aurora kinase that is a translation product of the human AURKB gene or a 1:1 ortholog thereof." [PRO:DNx]
PRO Category
gene
Parent
PR:000035365
aurora kinase
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
9
Sequence
0
Organism-Sequence
5
Modification
3
Organism-Modification
6
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:1937
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
gene
PR:000004517
aurora kinase B
AURKB
organism-gene
PR:000060242
serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe)
Spom-AURKB
organism-gene
PR:O01427
aurora/IPL1-related protein kinase 2 (worm)
AURKB (worm)
organism-gene
PR:O55099
aurora kinase B (rat)
rAURKB
organism-gene
PR:O59790
serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe 972h-)
Spom972h-AURKB
organism-gene
PR:O70126
aurora kinase B (mouse)
mAURKB
organism-gene
PR:Q6DE08
aurora kinase B-A (frog)
frog-AURKB
organism-gene
PR:Q6NW76
aurora kinase B (zebrafish)
z-AURKB
organism-gene
PR:Q96GD4
aurora kinase B (human)
hAURKB
Yes
organism-sequence
PR:Q96GD4-1
aurora kinase B isoform h1 (human)
hAURKB/iso:h1
organism-sequence
PR:Q96GD4-2
aurora kinase B isoform h2 (human)
hAURKB/iso:h2
organism-sequence
PR:Q96GD4-3
aurora kinase B isoform h3 (human)
hAURKB/iso:h3
organism-sequence
PR:Q96GD4-4
aurora kinase B isoform h4 (human)
hAURKB/iso:h4
organism-sequence
PR:Q96GD4-5
aurora kinase B isoform h5 (human)
hAURKB/iso:h5
organism-modification
PR:000035661
aurora kinase B unphosphorylated form (human)
hAURKB/PhosRes-
Yes
organism-modification
PR:000035663
aurora kinase B phosphorylated 1 (human)
hAURKB/Phos:1
Yes
organism-modification
PR:000046026
aurora kinase B phosphorylated 2 (human)
hAURKB/Phos:2
organism-modification
PR:000046440
aurora kinase B sumoylated 1 (human)
hAURKB/Sumo:1
organism-modification
PR:000075980
aurora kinase B methylated 1 (human)
hAURKB/Me:1
organism-modification
PR:000077527
aurora kinase B cysteinylated 1 (human)
hAURKB/Cyst:1
organism-gene
PR:Q9VKN7
aurora kinase B (fruit fly)
fly-AURKB
modification
PR:000019090
aurora kinase B, initiator methionine removed form
AURKB/InitMet-
modification
PR:000035660
aurora kinase B unphosphorylated form
AURKB/PhosRes-
organism-modification
PR:000035661
aurora kinase B unphosphorylated form (human)
hAURKB/PhosRes-
Yes
modification
PR:000035662
aurora kinase B phosphorylated 1
AURKB/Phos:1
organism-modification
PR:000035663
aurora kinase B phosphorylated 1 (human)
hAURKB/Phos:1
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000035661
hAURKB/PhosRes-
enables
GO:0005515
protein binding
with
PR:Q9NQS7
hINCENP
PMID:22024163
located_in
GO:0000776
kinetochore
PMID:22024163
PR:000035663
hAURKB/Phos:1
UniProtKB:Q96GD4, Ser-331, MOD:00046
acts_upstream_of_or_within
increased
GO:0007059
chromosome segregation
relative to
PR:000035661
hAURKB/PhosRes-
PMID:22024163
increased
GO:0031577
spindle checkpoint signaling
relative to
PR:000035661
hAURKB/PhosRes-
PMID:22024163
increased
GO:0051310
metaphase chromosome alignment
relative to
PR:000035661
hAURKB/PhosRes-
PMID:22024163
enables
increased
GO:0004672
protein kinase activity
relative to
PR:000035661
hAURKB/PhosRes-
PMID:17276342
;
PMID:22024163
GO:0005515
protein binding
PMID:22024163
located_in
GO:0000776
kinetochore
PMID:22024163
PR:Q96GD4
hAURKB
acts_upstream_of_or_within
GO:0007059
chromosome segregation
PMID:12719470
GO:0008608
attachment of spindle microtubules to kinetochore
PMID:12719470
;
PMID:15592459
GO:0031577
spindle checkpoint signaling
PMID:12719470
GO:0034501
protein localization to kinetochore
PMID:12719470
;
PMID:17617734
;
PMID:22732840
NOT
GO:0051306
mitotic sister chromatid separation
PMID:12719470
GO:0051310
metaphase chromosome alignment
PMID:12719470
;
PMID:22732840
GO:0071459
protein localization to chromosome, centromeric region
PMID:12719470
;
PMID:21658950
GO:0140014
mitotic nuclear division
PMID:12719470
enables
GO:0004672
protein kinase activity
PMID:12719470
GO:0005515
protein binding
with
PR:O60566
BUB1B
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
with
PR:P06493
CDC2
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
with
PR:P68431
H3C1
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
with
PR:Q12834
CDC20
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
with
PR:Q13043
hSTK4
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
with
PR:Q15208
hSTK38
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
with
PR:Q53HL2
CDCA8
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
with
PR:Q71DI3
H3-clustered histone 13 (human)
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
with
PR:Q9NQS7
hINCENP
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
GO:0005515
protein binding
BioGRID:BG-251075;
IntAct:EBI-1555366
;
MINT:MINT-77928
located_in
GO:0000776
kinetochore
PMID:20624902
GO:0000779
condensed chromosome, centromeric region
PMID:12719470
;
PMID:15917996
GO:0000939
inner kinetochore
PMID:15592459
GO:0030496
midbody
PMID:15917996
GO:0051233
spindle midzone
PMID:15917996