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Protein Ontology report - cell division cycle protein 20 homolog
PR:000005188 - http://purl.obolibrary.org/obo/PR_000005188
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000005188   
  PRO namecell division cycle protein 20 homolog 
  Synonyms
PRO-Short-label: EXACT:CDC20
Other: EXACT:mmCdc20 | p55CDC
  Definition"A protein that is a translation product of the human CDC20 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000005188

cell division cycle protein 20 homolog

CDC20


"A protein that is a translation product of the human CDC20 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P26309

APC/C activator protein CDC20 (yeast)

yCDC20


"A cell division cycle protein 20 homolog that is encoded in the genome of yeast." [PRO:KER]


organism-gene



PR:P78972

WD repeat-containing protein slp1 (Schizosaccharomyces pombe 972h-)

Spom972h-CDC20


"A cell division cycle protein 20 homolog that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:P78972, PRO:DNx]


organism-gene



PR:Q12834

cell division cycle protein 20 homolog (human)

hCDC20


"A cell division cycle protein 20 homolog that is encoded in the genome of human." [PMID:11030144, PMID:20624902, PRO:KER]

Yes

Yes
organism-sequence



PR:Q12834-1

cell division cycle protein 20 homolog isoform 1 (human)

hCDC20/iso:1


"A cell division cycle protein 20 homolog isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000035369

cell division cycle protein 20 homolog unphosphorylated form (human)

hCDC20/PhosRes-


"A cell division cycle protein 20 homolog unphosphorylated form in human." [PMID:15525512, PRO:KER]

Yes

organism-modification



PR:000035371

cell division cycle protein 20 homolog phosphorylated 1 (human)

hCDC20/Phos:1


"A cell division cycle protein 20 homolog phosphorylated 1 in human. This phosphorylated form occurs during mitotic splindle disruption (or with Nocodazole treatment) via BUB1 kinase activity. UniProtKB:Q12834, Ser-41/Ser-72/Ser-92/Ser-153/Ser-161, MOD:00046|Thr-157, MOD:00047." [PMID:15525512, PRO:KER]

Yes

organism-modification



PR:000035440

cell division cycle protein 20 homolog phosphorylated 2 (human)

hCDC20/Phos:2


"A cell division cycle protein 20 homolog phosphorylated 2 in human." [PMID:11030144, PRO:KER]


organism-modification



PR:000035442

cell division cycle protein 20 homolog phosphorylated 3 (human)

hCDC20/Phos:3


"A cell division cycle protein 20 homolog phosphorylated 3 in human. Potential sites Ser-41, Ser-408, Ser-452, Thr-55, Thr-59, Thr-70, Thr-106, Thr-157." [PMID:22566641, PRO:KER]

Yes

organism-modification



PR:000046658

cell division cycle protein 20 homolog ubiquitinated form (human)

hCDC20/UbiqLys+


"A cell division cycle protein 20 homolog (human) that includes at least one ubiquitinated lysine. UniProtKB:Q12834, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783069]


organism-modification



PR:000066860

cell division cycle protein 20 homolog cysteinylated 1 (human)

hCDC20/Cyst:1


"A cell division cycle protein 20 homolog (human) that has been cysteinylated on the residue at the position equivalent to Cys-403 of the amino acid sequence represented by UniProtKB:Q12834. UniProtKB:Q12834, Cys-403, MOD:00765." [IEDB_epitope:632268, PRO:DNx]


organism-modification



PR:000076113

cell division cycle protein 20 homolog methylated 1 (human)

hCDC20/Me:1


"A cell division cycle protein 20 homolog (human) that has been methylated on the residue at the position equivalent to Cys-403 of the amino acid sequence represented by UniProtKB:Q12834. UniProtKB:Q12834, Cys-403, MOD:00660." [IEDB_epitope:1019369, PRO:DNx]


organism-modification



PR:000079638

cell division cycle protein 20 homolog methylated 2 (human)

hCDC20/Me:2


"A cell division cycle protein 20 homolog (human) that has been methylated on the residue at the position equivalent to Cys-165 of the amino acid sequence represented by UniProtKB:Q12834. UniProtKB:Q12834, Cys-165, MOD:00660." [IEDB_epitope:1026934, PRO:DNx]


organism-modification



PR:000082105

cell division cycle protein 20 homolog deaminated 1 (human)

hCDC20/Deam:1


"A cell division cycle protein 20 homolog (human) that has been deaminated on the residue at the position equivalent to Asn-103 of the amino acid sequence represented by UniProtKB:Q12834. UniProtKB:Q12834, Asn-103, MOD:00684." [IEDB_epitope:1990372, PRO:DNx]


organism-gene



PR:Q62623

cell division cycle protein 20 homolog (rat)

rCDC20


"A cell division cycle protein 20 homolog that is encoded in the genome of rat." [OMA:Q62623, PRO:DNx]


organism-sequence



PR:Q62623-1

cell division cycle protein 20 homolog isoform 1 (rat)

rCDC20/iso:1


"A cell division cycle protein 20 homolog isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q6DFD4

cell division cycle protein 20 homolog (frog)

frog-CDC20


"A cell division cycle protein 20 homolog that is encoded in the genome of frog." [PRO:KER]


Yes
organism-modification



PR:000035444

cell division cycle protein 20 homolog phosphorylated 4 (frog)

frog-CDC20/Phos:4


"A cell division cycle protein 20 homolog phosphorylated 4 in frog. UniProtKB:Q6DFD4, Ser-50, MOD:00046|Thr-64/Thr-68/Thr-79, MOD:00047." [PMID:12855955, PRO:KER]

Yes

organism-modification



PR:000035628

cell division cycle protein 20 homolog unphosphorylated form (frog)

frog-CDC20/PhosRes-


"A cell division cycle protein 20 homolog unphosphorylated form in frog." [PRO:KER]


organism-gene



PR:Q9JJ66

cell division cycle protein 20 homolog (mouse)

mCDC20


"A cell division cycle protein 20 homolog that is encoded in the genome of mouse." [OMA:Q9JJ66, PRO:DNx]


organism-sequence



PR:Q9JJ66-1

cell division cycle protein 20 homolog isoform 1 (mouse)

mCDC20/iso:1


"A cell division cycle protein 20 homolog isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000040367

cell division cycle protein 20 homolog isoform 1

CDC20/iso:1


"A cell division cycle protein 20 homolog that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12834-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q12834-1

cell division cycle protein 20 homolog isoform 1 (human)

hCDC20/iso:1


"A cell division cycle protein 20 homolog isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q62623-1

cell division cycle protein 20 homolog isoform 1 (rat)

rCDC20/iso:1


"A cell division cycle protein 20 homolog isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9JJ66-1

cell division cycle protein 20 homolog isoform 1 (mouse)

mCDC20/iso:1


"A cell division cycle protein 20 homolog isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


modification



PR:000035368

cell division cycle protein 20 homolog unphosphorylated form

CDC20/PhosRes-


"A cell division cycle protein 20 homolog that lacks phosphorylated residues." [PMID:15525512, PRO:KER]


organism-modification



PR:000035369

cell division cycle protein 20 homolog unphosphorylated form (human)

hCDC20/PhosRes-


"A cell division cycle protein 20 homolog unphosphorylated form in human." [PMID:15525512, PRO:KER]

Yes

organism-modification



PR:000035628

cell division cycle protein 20 homolog unphosphorylated form (frog)

frog-CDC20/PhosRes-


"A cell division cycle protein 20 homolog unphosphorylated form in frog." [PRO:KER]


modification



PR:000035370

cell division cycle protein 20 homolog phosphorylated 1

CDC20/Phos:1


"A cell division cycle protein 20 homolog that has been phosphorylated at positions equivalent to Ser-41, Ser-72, Ser-92, Ser-153, Ser-161, and Thr-157 of the amino acid sequence represented by UniProtKB:Q12834. Example: UniProtKB:Q12834, Ser-41/Ser-72/Ser-92/Ser-153/Ser-161, MOD:00046|Thr-157, MOD:00047." [PMID:15525512, PRO:KER]


organism-modification



PR:000035371

cell division cycle protein 20 homolog phosphorylated 1 (human)

hCDC20/Phos:1


"A cell division cycle protein 20 homolog phosphorylated 1 in human. This phosphorylated form occurs during mitotic splindle disruption (or with Nocodazole treatment) via BUB1 kinase activity. UniProtKB:Q12834, Ser-41/Ser-72/Ser-92/Ser-153/Ser-161, MOD:00046|Thr-157, MOD:00047." [PMID:15525512, PRO:KER]

Yes

modification



PR:000035439

cell division cycle protein 20 homolog phosphorylated 2

CDC20/Phos:2


"A cell division cycle protein 20 homolog that has been phosphorylated by BUB1B. Example: UniProtKB:Q12834, MOD:00696." [PMID:11030144, PRO:KER]


organism-modification



PR:000035440

cell division cycle protein 20 homolog phosphorylated 2 (human)

hCDC20/Phos:2


"A cell division cycle protein 20 homolog phosphorylated 2 in human." [PMID:11030144, PRO:KER]


modification



PR:000035441

cell division cycle protein 20 homolog phosphorylated 3

CDC20/Phos:3


"A cell division cycle protein 20 homolog that has been phosphorylated on CDK1 consensus sites." [PMID:22566641, PRO:KER]


organism-modification



PR:000035442

cell division cycle protein 20 homolog phosphorylated 3 (human)

hCDC20/Phos:3


"A cell division cycle protein 20 homolog phosphorylated 3 in human. Potential sites Ser-41, Ser-408, Ser-452, Thr-55, Thr-59, Thr-70, Thr-106, Thr-157." [PMID:22566641, PRO:KER]

Yes

modification



PR:000035443

cell division cycle protein 20 homolog phosphorylated 4

CDC20/Phos:4


"A cell division cycle protein 20 homolog that has been phosphorylated during mitosis. Example: UniProtKB:Q6DFD4, Ser-50, MOD:00046|Thr-64/Thr-68/Thr-79, MOD:00047." [PMID:12855955, PRO:KER]


organism-modification



PR:000035444

cell division cycle protein 20 homolog phosphorylated 4 (frog)

frog-CDC20/Phos:4


"A cell division cycle protein 20 homolog phosphorylated 4 in frog. UniProtKB:Q6DFD4, Ser-50, MOD:00046|Thr-64/Thr-68/Thr-79, MOD:00047." [PMID:12855955, PRO:KER]

Yes

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CDC20 forms found in complexes   

CDC20 Component
Complexes
PR:Q12834 hCDC20 PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:000035575 BUB1B:CDC20 complex (human)
PR:Q6DFD4 frog-CDC20 PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035369 hCDC20/PhosRes- acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:15525512
enablesGO:0004842 ubiquitin-protein transferase activity PMID:15525512
GO:0005515 protein binding with PR:Q13257 hMAD2L1 PMID:15525512
GO:0005515 protein binding PMID:15525512
located_inGO:0000776 kinetochore PMID:15525512
PR:000035371 hCDC20/Phos:1
UniProtKB:Q12834, Ser-41/Ser-72/Ser-92/Ser-153/Ser-161, MOD:00046|Thr-157, MOD:00047
acts_upstream_of_or_withinincreased GO:0031577 spindle checkpoint signaling relative to PR:000035369 cdc20 unphosphorylated (human) PMID:15525512
enablesdecreased GO:0004842 ubiquitin-protein transferase activity relative to PR:000035369 cdc20 unphosphorylated (human) PMID:15525512
GO:0005515 protein binding with PR:Q13257 hMAD2L1 PMID:15525512
GO:0005515 protein binding PMID:15525512
located_inGO:0000776 kinetochore PMID:15525512
PR:000035442 hCDC20/Phos:3
Potential sites Ser-41, Ser-408, Ser-452, Thr-55, Thr-59, Thr-70, Thr-106, Thr-157
enablesdecreased GO:0005515 protein binding with PR:O60566 BUB1B PMID:22566641
PR:000035444 frog-CDC20/Phos:4
UniProtKB:Q6DFD4, Ser-50, MOD:00046|Thr-64/Thr-68/Thr-79, MOD:00047
acts_upstream_of_or_withinincreased GO:0031577 spindle checkpoint signaling relative to PR:000035628 cdc20 unphosphorylated (frog) PMID:12855955
enablesincreased GO:0005515 protein binding with PR:O60566 BUB1B PMID:12855955
increased GO:0005515 protein binding with PR:P79935 frog-MAD2L1 PMID:12855955
PR:Q12834 hCDC20 enablesGO:0005515 protein binding with PR:O60566 BUB1B PMID:20624902
GO:0005515 protein binding with PR:Q13257 hMAD2L1 PMID:20624902