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Protein Ontology report - serine/threonine-protein kinase Chk2
PR:000005418 - http://purl.obolibrary.org/obo/PR_000005418
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000005418   
  PRO nameserine/threonine-protein kinase Chk2 
  Synonyms
PRO-Short-label: EXACT:CHEK2
Gene-based: RELATED:CDS1 | CHK2 | RAD53
Other: EXACT:cds1 | checkpoint kinase 2 | CHK2 checkpoint homolog
  Definition"A protein that is a translation product of the human CHEK2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence0                                                  Organism-Sequence 15                                        
         Modification0                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1988
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000005418

serine/threonine-protein kinase Chk2

CHEK2


"A protein that is a translation product of the human CHEK2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:000030002

serine/threonine-protein kinase cds1 (Schizosaccharomyces pombe)

Spom-cds1


"A serine/threonine-protein kinase Chk2 that is encoded in the genome of Schizosaccharomyces pombe." [PRO:DAN]


organism-modification



PR:000037296

serine/threonine-protein kinase cds1 phosphorylated 1 (Schizosaccharomyces pombe)

Spom-cds1/Phos:1


"A serine/threonine-protein kinase cds1 (Schizosaccharomyces pombe) that has been phosphorylated on the Thr residue in the second TQ motif by rad3. Example: UniProtKB:Q09170, Thr-11, MOD:00047." [PMID:15173168, PomBase:AL]


Yes
organism-modification



PR:000037297

serine/threonine-protein kinase cds1 phosphorylated 2 (Schizosaccharomyces pombe)

Spom-cds1/Phos:2


"A serine/threonine-protein kinase cds1 (Schizosaccharomyces pombe) that has been phosphorylated on the Thr residue in the second TQ motif by rad3, and further phosphorylated at a second Thr within the activation loop by autocatalysis. Example: UniProtKB:Q09170, Thr-11/Thr-328, MOD:00047." [PMID:19357077, PomBase:AL]


Yes
organism-gene



PR:O61267

ovarian-specific serine/threonine-protein kinase Lok (fruit fly)

fly-CHEK2


"A serine/threonine-protein kinase Chk2 that is encoded in the genome of fruit fly." [PRO:DNx]


organism-sequence



PR:O61267-1

ovarian-specific serine/threonine-protein kinase Lok isoform Long (fruit fly)

fly-CHEK2/iso:Long


"An ovarian-specific serine/threonine-protein kinase Lok (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O61267-1." [PRO:DNx, UniProtKB:O61267]


organism-sequence



PR:O61267-2

ovarian-specific serine/threonine-protein kinase Lok isoform Short (fruit fly)

fly-CHEK2/iso:Short


"An ovarian-specific serine/threonine-protein kinase Lok (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O61267-2." [PRO:DNx, UniProtKB:O61267]


organism-gene



PR:O96017

serine/threonine-protein kinase Chk2 (human)

hCHEK2


"A serine/threonine-protein kinase Chk2 that is encoded in the genome of human." [OMA:O96017, PRO:DNx]


organism-sequence



PR:O96017-1

serine/threonine-protein kinase Chk2 isoform h1 (human)

hCHEK2/iso:h1


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-1." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-10

serine/threonine-protein kinase Chk2 isoform h10 (human)

hCHEK2/iso:h10


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-10." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-11

serine/threonine-protein kinase Chk2 isoform h11 (human)

hCHEK2/iso:h11


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-11." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-12

serine/threonine-protein kinase Chk2 isoform h12 (human)

hCHEK2/iso:h12


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-12." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-13

serine/threonine-protein kinase Chk2 isoform h13 (human)

hCHEK2/iso:h13


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-13." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-2

serine/threonine-protein kinase Chk2 isoform h2 (human)

hCHEK2/iso:h2


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-2." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-3

serine/threonine-protein kinase Chk2 isoform h3 (human)

hCHEK2/iso:h3


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-3." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-4

serine/threonine-protein kinase Chk2 isoform h4 (human)

hCHEK2/iso:h4


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-4." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-5

serine/threonine-protein kinase Chk2 isoform h5 (human)

hCHEK2/iso:h5


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-5." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-6

serine/threonine-protein kinase Chk2 isoform h6 (human)

hCHEK2/iso:h6


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-6." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-7

serine/threonine-protein kinase Chk2 isoform h7 (human)

hCHEK2/iso:h7


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-7." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-8

serine/threonine-protein kinase Chk2 isoform h8 (human)

hCHEK2/iso:h8


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-8." [PRO:DNx, UniProtKB:O96017]


organism-sequence



PR:O96017-9

serine/threonine-protein kinase Chk2 isoform h9 (human)

hCHEK2/iso:h9


"A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-9." [PRO:DNx, UniProtKB:O96017]


organism-modification



PR:000045624

serine/threonine-protein kinase Chk2 phosphorylated 1 (human)

hCHEK2/Phos:1


"A serine/threonine-protein kinase Chk2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-68 of the amino acid sequence represented by UniProtKB:O96017-1. Example: UniProtKB:O96017-1, Thr-68, MOD:00047." [iPTMnet:O96017, PMID:11085506, PMID:11668173, PMID:11901158, PMID:15342622, PMID:15533933, PMID:16311512]


organism-modification



PR:000046702

serine/threonine-protein kinase Chk2 phosphorylated 2 (human)

hCHEK2/Phos:2


"A serine/threonine-protein kinase Chk2 (human) that has been post-translationally modified to include phosphothreonine at positions 68, 383 and 387, and phosphoserine at position 379 of the amino acid sequence represented by UniProtKB:O96017. UniProtKB:O96017, Thr-68/Thr-383/Thr-387, MOD:00047|Ser-379, MOD:00046." [PRO:DNx, Reactome:R-HSA-5683784]


organism-modification



PR:000076150

serine/threonine-protein kinase Chk2 cysteinylated 1 (human)

hCHEK2/Cyst:1


"A serine/threonine-protein kinase Chk2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-231 of the amino acid sequence represented by UniProtKB:O96017-1. Example: UniProtKB:O96017-1, Cys-231, MOD:00765." [IEDB_epitope:1562808, PRO:DNx]


organism-gene



PR:P34101

probable serine/threonine-protein kinase fhkC (Dictyostelium discoideum)

Dicty-CHEK2


"A serine/threonine-protein kinase Chk2 that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]


organism-gene



PR:Q09170

serine/threonine-protein kinase cds1 (Schizosaccharomyces pombe 972h-)

Spom972h-CHEK2


"A serine/threonine-protein kinase Chk2 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09170, PRO:DNx]


organism-gene



PR:Q9Z265

serine/threonine-protein kinase Chk2 (mouse)

mCHEK2


"A serine/threonine-protein kinase Chk2 that is encoded in the genome of mouse." [OMA:MOUSE17342, PRO:DNx]


organism-modification



PR:000049820

serine/threonine-protein kinase Chk2 phosphorylated 1 (mouse)

mCHEK2/Phos:1


"A serine/threonine-protein kinase Chk2 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-383 of the amino acid sequence represented by UniProtKB:Q9Z265. UniProtKB:Q9Z265, Ser-383, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049821

serine/threonine-protein kinase Chk2 phosphorylated 2 (mouse)

mCHEK2/Phos:2


"A serine/threonine-protein kinase Chk2 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-540 of the amino acid sequence represented by UniProtKB:Q9Z265. UniProtKB:Q9Z265, Ser-540, MOD:00046." [PMID:21183079, PRO:HJD]


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CHEK2 forms found in complexes   

CHEK2 Component
Complexes
PR:000037296 Spom-cds1/Phos:1 PR:000037299 serine/threonine-protein kinase cds1 homodimer, phosphorylated 1 (Schizosaccharomyces pombe)
PR:000037297 Spom-cds1/Phos:2 PR:000037300 serine/threonine-protein kinase cds1 homodimer, phosphorylated 2 (Schizosaccharomyces pombe)