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Protein Ontology report - cochlin
PR:000005683 - http://purl.obolibrary.org/obo/PR_000005683
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000005683   
  PRO namecochlin 
  Synonyms
PRO-Short-label: EXACT:COCH
Gene-based: RELATED:COCH5B2 | UNQ257/PRO294
Other: EXACT:COCH-5B2
  Definition"A protein that is a translation product of the human COCH gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000005683

cochlin

COCH


"A protein that is a translation product of the human COCH gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O42163

cochlin (chicken)

chick-COCH


"A cochlin that is encoded in the genome of chicken." [PRO:DNx]


organism-gene



PR:O43405

cochlin (human)

hCOCH


"A cochlin that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43405]


organism-sequence



PR:O43405-1

cochlin isoform h1 (human)

hCOCH/iso:h1


"A cochlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43405-1." [PRO:DNx, UniProtKB:O43405]


organism-sequence



PR:O43405-2

cochlin isoform h2 (human)

hCOCH/iso:h2


"A cochlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43405-2." [PRO:DNx, UniProtKB:O43405]


organism-modification



PR:000069954

cochlin deaminated 1 (human)

hCOCH/Deam:1


"A cochlin (human) that has been deaminated on the residue at the position equivalent to Asn-175 of the amino acid sequence represented by UniProtKB:O43405-1. Example: UniProtKB:O43405-1, Asn-175, MOD:00684." [IEDB_epitope:1772630, PRO:DNx]


organism-modification



PR:000070549

cochlin methylated 1 (human)

hCOCH/Me:1


"A cochlin (human) that has been methylated on the residue at the position equivalent to Cys-54 of the amino acid sequence represented by UniProtKB:O43405-1. Example: UniProtKB:O43405-1, Cys-54, MOD:00660." [IEDB_epitope:1004149, PRO:DNx]


organism-modification



PR:000072750

cochlin cysteinylated 1 (human)

hCOCH/Cyst:1


"A cochlin (human) that has been cysteinylated on the residue at the position equivalent to Cys-162 of the amino acid sequence represented by UniProtKB:O43405-1. Example: UniProtKB:O43405-1, Cys-162, MOD:00765." [IEDB_epitope:2122653, IEDB_epitope:2122654, IEDB_epitope:2125478, PRO:DNx]


organism-modification



PR:000072901

cochlin methylated 2 (human)

hCOCH/Me:2


"A cochlin (human) that has been methylated on the residue at the position equivalent to Cys-34 of the amino acid sequence represented by UniProtKB:O43405-1. Example: UniProtKB:O43405-1, Cys-34, MOD:00660." [IEDB_epitope:997550, PRO:DNx]


organism-modification



PR:000073704

cochlin deaminated 2 (human)

hCOCH/Deam:2


"A cochlin (human) that has been deaminated on the residue at the position equivalent to Asn-436 of the amino acid sequence represented by UniProtKB:O43405-1. Example: UniProtKB:O43405-1, Asn-436, MOD:00684." [IEDB_epitope:1742544, PRO:DNx]


organism-gene



PR:Q62507

cochlin (mouse)

mCOCH


"A cochlin that is encoded in the genome of mouse." [OMA:Q62507, PRO:DNx]


organism-modification



PR:000037260

cochlin, signal peptide removed form (mouse)

mCOCH/SigPep-


"A cochlin (mouse) that the signal peptide has been removed. UniProtKB:Q62507, 27-552." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037261

cochlin p8 (mouse)

mCOCH/Clv:p8


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815) by aggrecanases proteolytic activity. This form results from the deglycosylation of the N-terminal fragment p18. UniProtKB:Q62507, 26-134." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037263

cochlin p40 (mouse)

mCOCH/Clv:p40


"A cochlin, signal peptide removed form (mouse) that results from further cleavage of the LCCL domain (Pfam:PF03815) after aggrecanases proteolytic activity. UniProtKB:Q62507, 135-552." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037264

cochlin, signal peptide removed glycosylated form (mouse)

mCOCH/SigPep-/GlycoRes+


"A cochlin, signal peptide removed form (mouse) that includes at least one glycosylated residue. UniProtKB:Q62507, 26-552, MOD:00693." [PMID:23684986, PRO:KRC]


organism-modification



PR:000037262

cochlin p18 (mouse)

mCOCH/Clv:p18


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815), and includes at least one glycosylated residue. UniProtKB:Q62507, 26-134, MOD:00693." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037265

cochlin precursor (mouse)

mCOCH/precursor


"A cochlin (mouse) that has not been subjected to any proteolytic cleavage. UniProtKB:Q62507, 1-552." [PMID:23684986, PRO:KRC]


union



PR:000037266

cochlin N-terminal fragment (mouse)

mCOCH/Nter


"A cochlin (mouse) that consists of the region upstream of LCCL domain (Pfam:PF03815) without the signal peptide. The fragment may or may not be glycosylated." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037261

cochlin p8 (mouse)

mCOCH/Clv:p8


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815) by aggrecanases proteolytic activity. This form results from the deglycosylation of the N-terminal fragment p18. UniProtKB:Q62507, 26-134." [PMID:23684986, PRO:KRC]


organism-modification



PR:000037262

cochlin p18 (mouse)

mCOCH/Clv:p18


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815), and includes at least one glycosylated residue. UniProtKB:Q62507, 26-134, MOD:00693." [PMID:23684986, PRO:KRC]


modification



PR:000037270

cochlin proteolytic cleavage product

COCH/ClvPrd


"A cochlin that has been processed by proteolytic cleavage." [PRO:CNA, PRO:DAN]


organism-modification



PR:000037261

cochlin p8 (mouse)

mCOCH/Clv:p8


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815) by aggrecanases proteolytic activity. This form results from the deglycosylation of the N-terminal fragment p18. UniProtKB:Q62507, 26-134." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037262

cochlin p18 (mouse)

mCOCH/Clv:p18


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815), and includes at least one glycosylated residue. UniProtKB:Q62507, 26-134, MOD:00693." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037263

cochlin p40 (mouse)

mCOCH/Clv:p40


"A cochlin, signal peptide removed form (mouse) that results from further cleavage of the LCCL domain (Pfam:PF03815) after aggrecanases proteolytic activity. UniProtKB:Q62507, 135-552." [PMID:23684986, PRO:KRC]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037260 mCOCH/SigPep-
UniProtKB:Q62507, 27-552
located_inGO:0031012 extracellular matrix MGI_ref:5525040; PMID:23684986
PR:000037261 mCOCH/Clv:p8
UniProtKB:Q62507, 26-134
located_inGO:0005576 extracellular region MGI_ref:5525040; PMID:23684986
PR:000037262 mCOCH/Clv:p18
UniProtKB:Q62507, 26-134, MOD:00693
located_inGO:0005576 extracellular region MGI_ref:5525040; PMID:23684986
PR:000037263 mCOCH/Clv:p40
UniProtKB:Q62507, 135-552
located_inGO:0031012 extracellular matrix MGI_ref:5525040; PMID:23684986
PR:000037266 mCOCH/Nter
The fragment may or may not be glycosylated
acts_upstream_of_or_withinGO:0042742 defense response to bacterium MGI_ref:5525040; PMID:23684986
GO:0045089 positive regulation of innate immune response MGI_ref:5525040; PMID:23684986