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Protein Ontology report - histone H2AX
PR:000008418 - http://purl.obolibrary.org/obo/PR_000008418
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000008418   
  PRO namehistone H2AX 
  Synonyms
PRO-Short-label: EXACT:H2AFX
Gene-based: RELATED:H2AX
Other: EXACT:H2a/x | histone H2A.X
RELATED:H2a.x | Hist5-2ax
  Definition"A histone H2A that is a translation product of the human H2AFX gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000027547 histone H2A
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000008418

histone H2AX

H2AFX


"A histone H2A that is a translation product of the human H2AFX gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:D3ZXP3

histone H2AX (rat)

rH2AFX


"A histone H2AX that is encoded in the genome of rat." [OMA:D3ZXP3, PRO:DNx]


organism-gene



PR:P16104

histone H2AX (human)

hH2AFX


"A histone H2AX that is encoded in the genome of human." [PRO:DNx, UniProtKB:P16104]


organism-sequence



PR:P16104-1

histone H2AX isoform 1 (human)

hH2AFX/iso:1


"A histone H2AX isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000047668

histone H2AX, initiator methionine removed form (human)

hH2AFX/InitMet-


"A histone H2AX (human) that has had the initiator methionine removed. UniProtKB:P16104, 2-143." [PRO:DNx, Reactome:R-HSA-56151, Reactome:R-HSA-977583]


organism-modification



PR:000045018

histone H2AX, initiator methionine removed acetylated 1 (human)

hH2AFX/InitMet-/Ac:1


"A histone H2AX (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H2A.x, PMID:17709392, PRO:DAN, PRO:JPB, PRO:JR]


organism-modification



PR:000045019

histone H2AX, initiator methionine removed ubiquitinated 1 (human)

hH2AFX/InitMet-/Ubiq:1


"A histone H2AX (human) that has had the initiator methionine removed and that has been ubiquitinated on the lysine at the position equivalent to Lys-120 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Lys-120, MOD:01148." [HIstome_var_Hs:Histone_H2A.x, PMID:15386022, PMID:18400894, PRO:DAN, PRO:JPB, PRO:JR]


organism-modification



PR:000045020

histone H2AX, initiator methionine removed phosphorylated 1 (human)

hH2AFX/InitMet-/Phos:1


"A histone H2AX (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-143 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Tyr-143, MOD:00048." [HIstome_var_Hs:Histone_H2A.x, PMID:19092802, PRO:DAN, PRO:JPB, PRO:JR]


organism-modification



PR:000045021

histone H2AX, initiator methionine removed acetylated 2 (human)

hH2AFX/InitMet-/Ac:2


"A histone H2AX (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Lys-10, MOD:00064." [HIstome_var_Hs:Histone_H2A.x, PMID:12937907, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]


organism-modification



PR:000045022

histone H2AX, initiator methionine removed phosphorylated 2 (human)

hH2AFX/InitMet-/Phos:2


"A histone H2AX (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-140 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Ser-140, MOD:00046." [HIstome_var_Hs:Histone_H2A.x, PMID:10734083, PMID:10959836, PMID:12660252, PMID:18370922, PRO:DAN, PRO:JPB, PRO:JR]


organism-modification



PR:000047669

histone H2AX, initiator methionine removed symmetrically-dimethylated 1 (human)

hH2AFX/InitMet-/Me2s:1


"A histone H2AX (human) that has had the initiator methionine removed and has been post-translationally modified to include symmetric dimethyl-L-arginine at position 4 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Arg-4, MOD:00076." [PRO:DNx, Reactome:R-HSA-5218317]


organism-modification



PR:000060462

histone H2AX, initiator methionine removed phosphorylated 3 (human)

hH2AFX/InitMet-/Phos:3


"A histone H2AX (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Ser-140 and Tyr-143 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Ser-140, MOD:00046|Tyr-143, MOD:00048." [PRO:DNx, Reactome:R-HSA-5683953]


organism-modification



PR:000064637

histone H2AX, initiator methionine removed phosphorylated and ubiquitinated 1 (human)

hH2AFX/InitMet-/PhosUbiq:1


"A histone H2AX (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-140 and ubiquitinated on the residues at the positions equivalent to Lys-14 and Lys-16 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Lys-14/Lys-16, MOD:01148|Ser-140, MOD:00046." [PRO:DNx, Reactome:R-HSA-5682847]


organism-modification



PR:000066026

histone H2AX deaminated 1 (human)

hH2AFX/Deam:1


"A histone H2AX (human) that has been deaminated on the residue at the position equivalent to Gln-25 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, Gln-25, MOD:00685." [IEDB_epitope:775245, PRO:DNx]


organism-modification



PR:000076720

histone H2AX deaminated 2 (human)

hH2AFX/Deam:2


"A histone H2AX (human) that has been deaminated on the residue at the position equivalent to Gln-105 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, Gln-105, MOD:00685." [IEDB_epitope:1375595, IEDB_epitope:1981605, PRO:DNx]


sequence



PR:000038946

histone H2AX isoform 1

H2AFX/iso:1


"A histone H2AX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16104-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P16104-1

histone H2AX isoform 1 (human)

hH2AFX/iso:1


"A histone H2AX isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P27661-1

histone H2AX isoform 1 (mouse)

mH2AFX/iso:1


"A histone H2AX isoform 1 that is encoded in the genome of mouse." [PRO:DNx]