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Protein Ontology report - prelamin-A/C
PR:000009859 - http://purl.obolibrary.org/obo/PR_000009859
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000009859   
  PRO nameprelamin-A/C 
  Synonyms
PRO-Short-label: EXACT:LMNA
Gene-based: RELATED:LMN1
Other: EXACT:70 kDa lamin | renal carcinoma antigen NY-REN-32
RELATED:lamin-A/C
  Definition"A protein that is a translation product of the human LMNA gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence3                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000009859

prelamin-A/C

LMNA


"A protein that is a translation product of the human LMNA gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P02545

prelamin-A/C (human)

hLMNA


"A prelamin-A/C that is encoded in the genome of human." [PRO:DNx, UniProtKB:P02545]


organism-sequence



PR:P02545-1

prelamin-A/C isoform A (human)

hLMNA/iso:A


"A prelamin-A/C isoform A that is encoded in the genome of human." [PMID:10080180]

Yes

organism-sequence



PR:P02545-2

prelamin-A/C isoform C (human)

hLMNA/iso:C


"A prelamin-A/C isoform C that is encoded in the genome of human." [PMID:10080180]

Yes

organism-modification



PR:000060751

prelamin-A/C isoform C phosphorylated 1 (human)

hLMNA/iso:C/Phos:1


"A prelamin-A/C isoform C (human) that has been phosphorylated on the residue at the position equivalent to Ser-395 of the amino acid sequence represented by UniProtKB:P02545-2. UniProtKB:P02545-2, Ser-395, MOD:00046." [PRO:DNx, Reactome:R-HSA-5228740]


organism-modification



PR:000060980

prelamin-A/C isoform C phosphorylated 2 (human)

hLMNA/iso:C/Phos:2


"A prelamin-A/C isoform C (human) that has been phosphorylated on the residues at the positions equivalent to Ser-22 and Ser-395 of the amino acid sequence represented by UniProtKB:P02545-2. UniProtKB:P02545-2, Ser-22/Ser-395, MOD:00046." [PRO:DNx, Reactome:R-HSA-5229019]


organism-sequence



PR:P02545-3

prelamin-A/C isoform ADelta10 (human)

hLMNA/iso:ADelta10


"A prelamin-A/C isoform C2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P02545-4

prelamin-A/C isoform h4 (human)

hLMNA/iso:h4


"A prelamin-A/C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02545-4." [PRO:DNx, UniProtKB:P02545]


organism-sequence



PR:P02545-5

prelamin-A/C isoform h5 (human)

hLMNA/iso:h5


"A prelamin-A/C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02545-5." [PRO:DNx, UniProtKB:P02545]


organism-sequence



PR:P02545-6

prelamin-A/C isoform h6 (human)

hLMNA/iso:h6


"A prelamin-A/C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02545-6." [PRO:DNx, UniProtKB:P02545]


organism-modification



PR:000067634

prelamin-A/C phosphorylated 1 (human)

hLMNA/Phos:1


"A prelamin-A/C (human) that has been phosphorylated on the residue at the position equivalent to Thr-224 of the amino acid sequence represented by UniProtKB:P02545-1. Example: UniProtKB:P02545-1, Thr-224, MOD:00047." [IEDB_epitope:2147354, PRO:DNx]


organism-modification



PR:000071566

prelamin-A/C deaminated 1 (human)

hLMNA/Deam:1


"A prelamin-A/C (human) that has been deaminated on the residue at the position equivalent to Gln-168 of the amino acid sequence represented by UniProtKB:P02545-1. Example: UniProtKB:P02545-1, Gln-168, MOD:00685." [IEDB_epitope:1980668, PRO:DNx]


organism-modification



PR:000072178

prelamin-A/C citrullinated 1 (human)

hLMNA/Cit:1


"A prelamin-A/C (human) that has been citrullinated on the residue at the position equivalent to Arg-196 of the amino acid sequence represented by UniProtKB:P02545-1. Example: UniProtKB:P02545-1, Arg-196, MOD:00219." [IEDB_epitope:912513, PRO:DNx]


organism-modification



PR:000073841

prelamin-A/C deaminated 2 (human)

hLMNA/Deam:2


"A prelamin-A/C (human) that has been deaminated on the residue at the position equivalent to Gln-207 of the amino acid sequence represented by UniProtKB:P02545-1. Example: UniProtKB:P02545-1, Gln-207, MOD:00685." [IEDB_epitope:771795, IEDB_epitope:771797, PRO:DNx]


organism-modification



PR:000074793

prelamin-A/C phosphorylated 2 (human)

hLMNA/Phos:2


"A prelamin-A/C (human) that has been phosphorylated on the residue at the position equivalent to Ser-414 of the amino acid sequence represented by UniProtKB:P02545-1. Example: UniProtKB:P02545-1, Ser-414, MOD:00046." [IEDB_epitope:847950, PRO:DNx]


organism-modification



PR:000083906

prelamin-A/C deaminated 3 (human)

hLMNA/Deam:3


"A prelamin-A/C (human) that has been deaminated on the residue at the position equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P02545-1. Example: UniProtKB:P02545-1, Asn-231, MOD:00684." [IEDB_epitope:1368789, IEDB_epitope:779209, PRO:DNx]


organism-modification



PR:000085196

prelamin-A/C deaminated 4 (human)

hLMNA/Deam:4


"A prelamin-A/C (human) that has been deaminated on the residue at the position equivalent to Asn-209 of the amino acid sequence represented by UniProtKB:P02545-1. Example: UniProtKB:P02545-1, Asn-209, MOD:00684." [IEDB_epitope:771796, PRO:DNx]


organism-gene



PR:P13648

lamin-A (chicken)

chick-LMNA


"A prelamin-A/C that is encoded in the genome of chicken." [PRO:DAN]


organism-gene



PR:P48678

prelamin-A/C (mouse)

mLMNA


"A prelamin-A/C that is encoded in the genome of mouse." [OMA:P48678, PRO:DNx]


organism-sequence



PR:P48678-1

prelamin-A/C isoform A (mouse)

mLMNA/iso:A


"A prelamin-A/C isoform A that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]


organism-sequence



PR:P48678-2

prelamin-A/C isoform C (mouse)

mLMNA/iso:C


"A prelamin-A/C isoform C that is encoded in the genome of mouse." [PMID:2719959, PRO:HJD]


organism-sequence



PR:P48678-3

prelamin-A/C isoform C2 (mouse)

mLMNA/iso:C2


"A prelamin-A/C isoform C2 that is encoded in the genome of mouse." [PMID:8187835, PRO:HJD]


organism-gene



PR:P48679

prelamin-A/C (rat)

rLMNA


"A prelamin-A/C that is encoded in the genome of rat." [OMA:P48679, PRO:DNx]


organism-sequence



PR:P48679-1

prelamin-A/C isoform Lamin A (rat)

rLMNA/iso:Lamin A


"A prelamin-A/C (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48679-1." [PRO:DNx, UniProtKB:P48679]


organism-sequence



PR:P48679-2

prelamin-A/C isoform Lamin C (rat)

rLMNA/iso:Lamin C


"A prelamin-A/C (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48679-2." [PRO:DNx, UniProtKB:P48679]


organism-gene



PR:Q54HI5

lamin-like protein (Dictyostelium discoideum)

Dicty-LMNA


"A prelamin-A/C that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]


sequence



PR:000026539

prelamin-A/C isoform A

LMNA/iso:A


"A prelamin-A/C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02545-1 or a 1:1 ortholog thereof." [PMID:10080180]


organism-sequence



PR:P02545-1

prelamin-A/C isoform A (human)

hLMNA/iso:A


"A prelamin-A/C isoform A that is encoded in the genome of human." [PMID:10080180]

Yes

organism-sequence



PR:P48678-1

prelamin-A/C isoform A (mouse)

mLMNA/iso:A


"A prelamin-A/C isoform A that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]


sequence



PR:000026541

prelamin-A/C isoform C

LMNA/iso:C


"A prelamin-A/C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02545-2 or a 1:1 ortholog thereof." [PMID:10080180]


organism-sequence



PR:P02545-2

prelamin-A/C isoform C (human)

hLMNA/iso:C


"A prelamin-A/C isoform C that is encoded in the genome of human." [PMID:10080180]

Yes

organism-modification



PR:000060751

prelamin-A/C isoform C phosphorylated 1 (human)

hLMNA/iso:C/Phos:1


"A prelamin-A/C isoform C (human) that has been phosphorylated on the residue at the position equivalent to Ser-395 of the amino acid sequence represented by UniProtKB:P02545-2. UniProtKB:P02545-2, Ser-395, MOD:00046." [PRO:DNx, Reactome:R-HSA-5228740]


organism-modification



PR:000060980

prelamin-A/C isoform C phosphorylated 2 (human)

hLMNA/iso:C/Phos:2


"A prelamin-A/C isoform C (human) that has been phosphorylated on the residues at the positions equivalent to Ser-22 and Ser-395 of the amino acid sequence represented by UniProtKB:P02545-2. UniProtKB:P02545-2, Ser-22/Ser-395, MOD:00046." [PRO:DNx, Reactome:R-HSA-5229019]


organism-sequence



PR:P48678-2

prelamin-A/C isoform C (mouse)

mLMNA/iso:C


"A prelamin-A/C isoform C that is encoded in the genome of mouse." [PMID:2719959, PRO:HJD]


sequence



PR:000037391

prelamin-A/C isoform C2

LMNA/iso:C2


"A prelamin-A/C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02545-3 or a 1:1 ortholog thereof." [PMID:8187835, PRO:HJD]


organism-sequence



PR:P02545-3

prelamin-A/C isoform ADelta10 (human)

hLMNA/iso:ADelta10


"A prelamin-A/C isoform C2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P48678-3

prelamin-A/C isoform C2 (mouse)

mLMNA/iso:C2


"A prelamin-A/C isoform C2 that is encoded in the genome of mouse." [PMID:8187835, PRO:HJD]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0007517 muscle organ developmentPR:P02545-1 hLMNA/iso:A PMID:10080180
PR:P02545-2 hLMNA/iso:C PMID:10080180

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005198 structural molecule activityPR:P02545-1 hLMNA/iso:A PMID:8344919
PR:P02545-1 hLMNA/iso:A PMID:8344919
PR:P02545-1 hLMNA/iso:A PMID:8344919
PR:P02545-1 hLMNA/iso:A PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
GO:0005515 protein bindingPR:P02545-1 hLMNA/iso:A PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623
PR:P02545-2 hLMNA/iso:C PMID:10381623

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005635 nuclear envelopePR:P02545-1 hLMNA/iso:A PMID:3453101
PR:P02545-2 hLMNA/iso:C PMID:3453101
GO:0005638 lamin filamentPR:P02545-1 hLMNA/iso:A PMID:10080180
PR:P02545-2 hLMNA/iso:C PMID:10080180
GO:0005652 nuclear laminaPR:P02545-1 hLMNA/iso:A PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
GO:0005882 intermediate filamentPR:P02545-1 hLMNA/iso:A PMID:8344919
PR:P02545-2 hLMNA/iso:C PMID:8344919
GO:0048471 perinuclear region of cytoplasmPR:P02545-1 hLMNA/iso:A PMID:10080180
PR:P02545-2 hLMNA/iso:C PMID:10080180